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Chemical Compound Review

CHEMBL137264     1,2,4-trichloro-5-(3,4- dichlorophenyl)benzene

Synonyms: AG-F-05079, SureCN2279480, LS-1181, PCB 118, CTK4G7250, ...
 
 
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Disease relevance of PCB 118

 

High impact information on PCB 118

 

Biological context of PCB 118

  • Aquarium experiments with dab (Limanda limanda) were carried out to examine the effects of exposure to cadmium, PCB 118, and PCB 77 (each 1 mg/kg fish wt) on apoptosis in dab liver [7].
 

Anatomical context of PCB 118

  • In a histological evaluation of thyroids, the PCB 118 pups revealed changes suggestive of sustained TSH stimulation, including increased follicular cell vacuolization and height, increased nuclear vesiculation, and decreased colloid area [8].
  • These results demonstrate that PCB-118 is an effective inducer of the subfamily cytochrome P450IA1 in rainbow trout liver microsomes [1].
 

Analytical, diagnostic and therapeutic context of PCB 118

References

  1. Response of xenobiotic metabolizing enzymes of rainbow trout (Oncorhynchus mykiss) to the mono-ortho substituted polychlorinated PCB congener 2,3',4,4',5-pentachlorobiphenyl, PCB-118, detected by enzyme activities and immunochemical methods. Skaare, J.U., Jensen, E.G., Goksøyr, A., Egaas, E. Arch. Environ. Contam. Toxicol. (1991) [Pubmed]
  2. Effects of several dioxin-like compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines. van Duursen, M.B., Sanderson, J.T., van der Bruggen, M., van der Linden, J., van den Berg, M. Toxicol. Appl. Pharmacol. (2003) [Pubmed]
  3. Application of an ELISA for PCB 118 to the screening of dioxin-like PCBs in retail fish. Tsutsumi, T., Amakura, Y., Okuyama, A., Tanioka, Y., Sakata, K., Sasaki, K., Maitani, T. Chemosphere (2006) [Pubmed]
  4. Characterization of bronchiolar metaplasia of the alveolar epithelium in female Sprague-Dawley rats exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB126). Brix, A.E., Jokinen, M.P., Walker, N.J., Sells, D.M., Nyska, A. Toxicologic pathology. (2004) [Pubmed]
  5. In utero exposure to low-dose 2,3',4,4',5-pentachlorobiphenyl (PCB 118) impairs male fertility and alters neurobehavior in rat offspring. Kuriyama, S.N., Chahoud, I. Toxicology (2004) [Pubmed]
  6. The relation between levels of selected PCB congeners in human serum and follicular fluid. Pauwels, A., Covaci, A., Delbeke, L., Punjabi, U., Schepens, P.J. Chemosphere (1999) [Pubmed]
  7. Apoptosis in dab (Limanda limanda) as possible new biomarker for anthropogenic stress. Piechotta, G., Lacorn, M., Lang, T., Kammann, U., Simat, T., Jenke, H.S., Steinhart, H. Ecotoxicol. Environ. Saf. (1999) [Pubmed]
  8. Effects of perinatal exposure to specific PCB congeners on thyroid hormone concentrations and thyroid histology in the rat. Ness, D.K., Schantz, S.L., Moshtaghian, J., Hansen, L.G. Toxicol. Lett. (1993) [Pubmed]
  9. Promotion of altered hepatic foci by 2,3',4,4',5-pentachlorobiphenyl in Sprague-Dawley female rats. Haag-Grönlund, M., Wärngård, L., Flodström, S., Scheu, G., Kronevi, T., Ahlborg, U.G., Fransson-Steen, R. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1997) [Pubmed]
 
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