The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CHEMBL137264     1,2,4-trichloro-5-(3,4- dichlorophenyl)benzene

Synonyms: AG-F-05079, SureCN2279480, LS-1181, PCB 118, CTK4G7250, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PCB 118


High impact information on PCB 118


Biological context of PCB 118

  • Aquarium experiments with dab (Limanda limanda) were carried out to examine the effects of exposure to cadmium, PCB 118, and PCB 77 (each 1 mg/kg fish wt) on apoptosis in dab liver [7].

Anatomical context of PCB 118

  • In a histological evaluation of thyroids, the PCB 118 pups revealed changes suggestive of sustained TSH stimulation, including increased follicular cell vacuolization and height, increased nuclear vesiculation, and decreased colloid area [8].
  • These results demonstrate that PCB-118 is an effective inducer of the subfamily cytochrome P450IA1 in rainbow trout liver microsomes [1].

Analytical, diagnostic and therapeutic context of PCB 118


  1. Response of xenobiotic metabolizing enzymes of rainbow trout (Oncorhynchus mykiss) to the mono-ortho substituted polychlorinated PCB congener 2,3',4,4',5-pentachlorobiphenyl, PCB-118, detected by enzyme activities and immunochemical methods. Skaare, J.U., Jensen, E.G., Goksøyr, A., Egaas, E. Arch. Environ. Contam. Toxicol. (1991) [Pubmed]
  2. Effects of several dioxin-like compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines. van Duursen, M.B., Sanderson, J.T., van der Bruggen, M., van der Linden, J., van den Berg, M. Toxicol. Appl. Pharmacol. (2003) [Pubmed]
  3. Application of an ELISA for PCB 118 to the screening of dioxin-like PCBs in retail fish. Tsutsumi, T., Amakura, Y., Okuyama, A., Tanioka, Y., Sakata, K., Sasaki, K., Maitani, T. Chemosphere (2006) [Pubmed]
  4. Characterization of bronchiolar metaplasia of the alveolar epithelium in female Sprague-Dawley rats exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB126). Brix, A.E., Jokinen, M.P., Walker, N.J., Sells, D.M., Nyska, A. Toxicologic pathology. (2004) [Pubmed]
  5. In utero exposure to low-dose 2,3',4,4',5-pentachlorobiphenyl (PCB 118) impairs male fertility and alters neurobehavior in rat offspring. Kuriyama, S.N., Chahoud, I. Toxicology (2004) [Pubmed]
  6. The relation between levels of selected PCB congeners in human serum and follicular fluid. Pauwels, A., Covaci, A., Delbeke, L., Punjabi, U., Schepens, P.J. Chemosphere (1999) [Pubmed]
  7. Apoptosis in dab (Limanda limanda) as possible new biomarker for anthropogenic stress. Piechotta, G., Lacorn, M., Lang, T., Kammann, U., Simat, T., Jenke, H.S., Steinhart, H. Ecotoxicol. Environ. Saf. (1999) [Pubmed]
  8. Effects of perinatal exposure to specific PCB congeners on thyroid hormone concentrations and thyroid histology in the rat. Ness, D.K., Schantz, S.L., Moshtaghian, J., Hansen, L.G. Toxicol. Lett. (1993) [Pubmed]
  9. Promotion of altered hepatic foci by 2,3',4,4',5-pentachlorobiphenyl in Sprague-Dawley female rats. Haag-Grönlund, M., Wärngård, L., Flodström, S., Scheu, G., Kronevi, T., Ahlborg, U.G., Fransson-Steen, R. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1997) [Pubmed]
WikiGenes - Universities