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Chemical Compound Review

SureCN465678     4-amino-1-[2-(hydroxymethyl)- 1,3...

Synonyms: AG-D-70884, ACMC-209tyk, ACMC-20mvgi, NSC-620753, NSC-760061, ...
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Disease relevance of BCH-189


High impact information on BCH-189


Chemical compound and disease context of BCH-189


Associations of BCH-189 with other chemical compounds


  1. Development of HIV-1 resistance to (-)2'-deoxy-3'-thiacytidine in patients with AIDS or advanced AIDS-related complex. Wainberg, M.A., Salomon, H., Gu, Z., Montaner, J.S., Cooley, T.P., McCaffrey, R., Ruedy, J., Hirst, H.M., Cammack, N., Cameron, J. AIDS (1995) [Pubmed]
  2. Clinical pharmacokinetics of lamivudine. Johnson, M.A., Moore, K.H., Yuen, G.J., Bye, A., Pakes, G.E. Clinical pharmacokinetics. (1999) [Pubmed]
  3. The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine. Gao, Q., Gu, Z., Parniak, M.A., Cameron, J., Cammack, N., Boucher, C., Wainberg, M.A. Antimicrob. Agents Chemother. (1993) [Pubmed]
  4. Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2'-deoxy-3'-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog. Soudeyns, H., Yao, X.I., Gao, Q., Belleau, B., Kraus, J.L., Nguyen-Ba, N., Spira, B., Wainberg, M.A. Antimicrob. Agents Chemother. (1991) [Pubmed]
  5. Enzymatic production of optically pure (2'R-cis)-2'-deoxy-3'-thiacytidine (3TC, lamivudine): a potent anti-HIV agent. Mahmoudian, M., Baines, B.S., Drake, C.S., Hale, R.S., Jones, P., Piercey, J.E., Montgomery, D.S., Purvis, I.J., Storer, R., Dawson, M.J. Enzyme Microb. Technol. (1993) [Pubmed]
  6. Selection and characterization of human immunodeficiency virus type 1 variants resistant to the (+) and (-) enantiomers of 2'-deoxy-3'-oxa-4'-thio-5-fluorocytidine. Richard, N., Salomon, H., Rando, R., Mansour, T., Bowlin, T.L., Wainberg, M.A. Antimicrob. Agents Chemother. (2000) [Pubmed]
  7. The M539V polymerase variant of human hepatitis B virus demonstrates resistance to 2'-deoxy-3'-thiacytidine and a reduced ability to synthesize viral DNA. Ladner, S.K., Miller, T.J., King, R.W. Antimicrob. Agents Chemother. (1998) [Pubmed]
  8. Increased activation of the combination of 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine in the presence of hydroxyurea. Palmer, S., Cox, S. Antimicrob. Agents Chemother. (1997) [Pubmed]
  9. High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase. Boucher, C.A., Cammack, N., Schipper, P., Schuurman, R., Rouse, P., Wainberg, M.A., Cameron, J.M. Antimicrob. Agents Chemother. (1993) [Pubmed]
  10. Utilization of transgenic mice replicating high levels of hepatitis B virus for antiviral evaluation of lamivudine. Morrey, J.D., Bailey, K.W., Korba, B.E., Sidwell, R.W. Antiviral Res. (1999) [Pubmed]
  11. Determination of 2'-deoxy-3'-thiacytidine (3TC) in human urine by liquid chromatography: direct injection with column switching. Morris, D.M., Selinger, K. Journal of pharmaceutical and biomedical analysis. (1994) [Pubmed]
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