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MeSH Review

AIDS-Related Complex

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Disease relevance of AIDS-Related Complex


High impact information on AIDS-Related Complex


Chemical compound and disease context of AIDS-Related Complex


Biological context of AIDS-Related Complex


Anatomical context of AIDS-Related Complex


Gene context of AIDS-Related Complex

  • Relative to normal cells, the expression of AFP and IL-2 receptors appeared considerably reduced in AIDS-related complex (ARC) and AIDS patients [23].
  • Vif antibodies were detected only in a low percentage in early stages of disease, but their prevalence increased to 36% and 72% with progression of disease to AIDS-related complex and AIDS [24].
  • Vasoactive intestinal polypeptide (VIP) secretion and refractory diarrhea in patients with AIDS or AIDS-related complex (ARC) [25].
  • Relatively low dose treatment (150 mg/kg, once per two weeks) of a intravenous immunoglobulin (IVI) preparation has shown a beneficial effect on CD4/CD8 ratio and CD4 cell counts in two patients with AIDS-related complex (ARC) [26].
  • Ten patients with hemophilia and HIV infection [8 asymptomatic carriers (AC) and 2 AIDS-related complex (ARC)] were intravenously injected with 1 million IU of IFN-beta twice a week for 6 months [27].

Analytical, diagnostic and therapeutic context of AIDS-Related Complex


  1. Once-daily administration of 2',3'-dideoxyinosine (ddI) in patients with the acquired immunodeficiency syndrome or AIDS-related complex. Results of a Phase I trial. Cooley, T.P., Kunches, L.M., Saunders, C.A., Ritter, J.K., Perkins, C.J., McLaren, C., McCaffrey, R.P., Liebman, H.A. N. Engl. J. Med. (1990) [Pubmed]
  2. Altered erythrocyte C3b receptor expression, immune complexes, and complement activation in homosexual men in varying risk groups for acquired immune deficiency syndrome. Tausk, F.A., McCutchan, A., Spechko, P., Schreiber, R.D., Gigli, I. J. Clin. Invest. (1986) [Pubmed]
  3. Effects of suramin on HTLV-III/LAV infection presenting as Kaposi's sarcoma or AIDS-related complex: clinical pharmacology and suppression of virus replication in vivo. Broder, S., Yarchoan, R., Collins, J.M., Lane, H.C., Markham, P.D., Klecker, R.W., Redfield, R.R., Mitsuya, H., Hoth, D.F., Gelmann, E. Lancet (1985) [Pubmed]
  4. Plasma viremia in human immunodeficiency virus infection. Coombs, R.W., Collier, A.C., Allain, J.P., Nikora, B., Leuther, M., Gjerset, G.F., Corey, L. N. Engl. J. Med. (1989) [Pubmed]
  5. Reduced Langerhans' cell Ia antigen and ATPase activity in patients with the acquired immunodeficiency syndrome. Belsito, D.V., Sanchez, M.R., Baer, R.L., Valentine, F., Thorbecke, G.J. N. Engl. J. Med. (1984) [Pubmed]
  6. Endogenous interferon and triglyceride concentrations to assess response to zidovudine in AIDS and advanced AIDS-related complex. Mildvan, D., Machado, S.G., Wilets, I., Grossberg, S.E. Lancet (1992) [Pubmed]
  7. Clinical, immunological, and virological effects of ampligen, a mismatched double-stranded RNA, in patients with AIDS or AIDS-related complex. Carter, W.A., Strayer, D.R., Brodsky, I., Lewin, M., Pellegrino, M.G., Einck, L., Henriques, H.F., Simon, G.L., Parenti, D.M., Scheib, R.G. Lancet (1987) [Pubmed]
  8. Rapid, easy, and economical screening test for antibodies to human immunodeficiency virus. Carlson, J.R., Mertens, S.C., Yee, J.L., Gardner, M.B., Watson-Williams, E.J., Ghrayeb, J., Jennings, M.B., Biggar, R.J. Lancet (1987) [Pubmed]
  9. Neuropsychological outcome of zidovudine (AZT) treatment of patients with AIDS and AIDS-related complex. Schmitt, F.A., Bigley, J.W., McKinnis, R., Logue, P.E., Evans, R.W., Drucker, J.L. N. Engl. J. Med. (1988) [Pubmed]
  10. Urinary neopterin and biopterin levels in patients with AIDS and AIDS-related complex. Abita, J.P., Cost, H., Milstien, S., Kaufman, S., Saimot, G. Lancet (1985) [Pubmed]
  11. Alternating and intermittent regimens of zidovudine and dideoxycytidine in patients with AIDS or AIDS-related complex. Skowron, G., Bozzette, S.A., Lim, L., Pettinelli, C.B., Schaumburg, H.H., Arezzo, J., Fischl, M.A., Powderly, W.G., Gocke, D.J., Richman, D.D., Pottage, J.C., Antoniskis, D., McKinley, G.F., Hyslop, N.E., Ray, G., Simon, G., Reed, N., LoFaro, M.L., Uttamchandani, R.B., Gelb, L.D., Sperber, S.J., Murphy, R.L., Leedom, J.M., Grieco, M.H., Zachary, J., Hirsch, M.S., Spector, S.A., Bigley, J., Soo, W., Merigan, T.C. Ann. Intern. Med. (1993) [Pubmed]
  12. Ribavirin treatment of the acquired immunodeficiency syndrome (AIDS) and the acquired-immunodeficiency-syndrome-related complex (ARC). A phase 1 study shows transient clinical improvement associated with suppression of the human immunodeficiency virus and enhanced lymphocyte proliferation. Crumpacker, C., Heagy, W., Bubley, G., Monroe, J.E., Finberg, R., Hussey, S., Schnipper, L., Lucey, D., Lee, T.H., McLane, M.F. Ann. Intern. Med. (1987) [Pubmed]
  13. The safety and pharmacokinetics of recombinant soluble CD4 (rCD4) in subjects with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. A phase 1 study. Kahn, J.O., Allan, J.D., Hodges, T.L., Kaplan, L.D., Arri, C.J., Fitch, H.F., Izu, A.E., Mordenti, J., Sherwin, J.E., Groopman, J.E. Ann. Intern. Med. (1990) [Pubmed]
  14. Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity. Larder, B.A., Kemp, S.D., Purifoy, D.J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  15. Differential gene expression of IFN-alpha and tumor necrosis factor-alpha in peripheral blood mononuclear cells from patients with AIDS related complex and AIDS. Voth, R., Rossol, S., Klein, K., Hess, G., Schütt, K.H., Schröder, H.C., Meyer zum Büschenfelde, K.H., Müller, W.E. J. Immunol. (1990) [Pubmed]
  16. Pharmacokinetics of didanosine in patients with acquired immunodeficiency syndrome or acquired immunodeficiency syndrome-related complex. Knupp, C.A., Shyu, W.C., Dolin, R., Valentine, F.T., McLaren, C., Martin, R.R., Pittman, K.A., Barbhaiya, R.H. Clin. Pharmacol. Ther. (1991) [Pubmed]
  17. Lack of effect of concomitant zidovudine on rifabutin kinetics in patients with AIDS-related complex. Li, R.C., Nightingale, S., Lewis, R.C., Colborn, D.C., Narang, P.K. Antimicrob. Agents Chemother. (1996) [Pubmed]
  18. Human cytomegalovirus viraemia in HIV-1-seropositive patients at various clinical stages of infection. Gerna, G., Parea, M., Percivalle, E., Zipeto, D., Silini, E., Barbarini, G., Milanesi, G. AIDS (1990) [Pubmed]
  19. AIDS and antibodies to human immunodeficiency virus (HIV) in children and their families. Martin, K., Katz, B.Z., Miller, G. J. Infect. Dis. (1987) [Pubmed]
  20. AIDS-related complex treated by antiviral drugs and allogeneic bone marrow transplantation following conditioning protocol with busulphan, cyclophosphamide and cyclosporin. Torlontano, G., Di Bartolomeo, P., Di Girolamo, G., Angrilli, F., Verani, P., Maggiorella, M.T., Dragani, A., Iacone, A., Papalinetti, G., Olioso, P. Haematologica (1992) [Pubmed]
  21. Effects of recombinant human granulocyte colony-stimulating factor on leucopenia in zidovudine-treated patients with AIDS and AIDS related complex, a phase I/II study. van der Wouw, P.A., van Leeuwen, R., van Oers, R.H., Lange, J.M., Danner, S.A. Br. J. Haematol. (1991) [Pubmed]
  22. Thiamine deficiency and Wernicke's encephalopathy in AIDS. Butterworth, R.F., Gaudreau, C., Vincelette, J., Bourgault, A.M., Lamothe, F., Nutini, A.M. Metabolic brain disease. (1991) [Pubmed]
  23. Expression of alpha-fetoprotein and interleukin 2 receptors and impairment of membrane fluidity in peripheral blood mononuclear cells from AIDS and related syndromes. Macho, A., Aguilar, J.J., Naval, J., Girard, P.M., Uriel, J. AIDS Res. Hum. Retroviruses (1994) [Pubmed]
  24. Antibodies to recombinant HIV-1 vif, tat, and nef proteins in human sera. Wieland, U., Kühn, J.E., Jassoy, C., Rübsamen-Waigmann, H., Wolber, V., Braun, R.W. Med. Microbiol. Immunol. (Berl.) (1990) [Pubmed]
  25. Vasoactive intestinal polypeptide (VIP) secretion and refractory diarrhea in patients with AIDS or AIDS-related complex (ARC). Manfredi, R., Vezzadini, P., Fanti, M.P., Chiodo, F. Scand. J. Infect. Dis. (1994) [Pubmed]
  26. Effect of immunoglobulin preparation on course of AIDS-related complex (ARC). Ohno, T., Kanoh, T., Uchino, H., Harada, S. Tohoku J. Exp. Med. (1988) [Pubmed]
  27. Beta-interferon and early stage HIV infection. Oka, S., Hirabayashi, Y., Mouri, H., Sakurada, S., Goto, H., Ohnishi, K., Kimura, S., Mitamura, K., Shimada, K. J. Acquir. Immune Defic. Syndr. (1989) [Pubmed]
  28. Polymerase chain reaction evidence for human immunodeficiency virus 1 neutralization by passive immunization in patients with AIDS and AIDS-related complex. Karpas, A., Hewlett, I.K., Hill, F., Gray, J., Byron, N., Gilgen, D., Bally, V., Oates, J.K., Gazzard, B., Epstein, J.E. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  29. Future treatment strategies in HIV infection. Dormont, J. AIDS (1994) [Pubmed]
  30. Association of human immunodeficiency virus infection and autoimmune phenomena. Kopelman, R.G., Zolla-Pazner, S. Am. J. Med. (1988) [Pubmed]
  31. Utility of total body gallium-67 scintigraphy in a patient with AIDS related complex. Ford, P.V., Lim, A.B., Abrams, D., Parker, H.G. J. Nucl. Med. (1987) [Pubmed]
  32. Distribution of the level of antibody to AIDS-associated virus (LAV) in sera from AIDS or AIDS related complex and Japanese hemophiliacs infected with AIDS-associated virus. Tsuchie, H., Kawatani, T., Nakayama, E., Matsui, T., Kurimura, T., Hinuma, Y. Microbiol. Immunol. (1985) [Pubmed]
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