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Gene Review

ECs3035  -  cytidine deaminase

Escherichia coli O157:H7 str. Sakai

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Disease relevance of ECs3035


High impact information on ECs3035


Chemical compound and disease context of ECs3035


Biological context of ECs3035

  • Role of glutamate-104 in generating a transition state analogue inhibitor at the active site of cytidine deaminase [7].

Associations of ECs3035 with chemical compounds


Analytical, diagnostic and therapeutic context of ECs3035


  1. Purification and properties of cytidine deaminase from escherichia coli. Ashley, G.W., Bartlett, P.A. J. Biol. Chem. (1984) [Pubmed]
  2. The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation. Petersen, C., Møller, L.B. J. Biol. Chem. (2001) [Pubmed]
  3. Inhibition of Escherichia coli cytidine deaminase by a phosphapyrimidine nucleoside. Ashley, G.W., Bartlett, P.A. J. Biol. Chem. (1984) [Pubmed]
  4. Escherichia coli cytidine deaminase provides a molecular model for ApoB RNA editing and a mechanism for RNA substrate recognition. Navaratnam, N., Fujino, T., Bayliss, J., Jarmuz, A., How, A., Richardson, N., Somasekaram, A., Bhattacharya, S., Carter, C., Scott, J. J. Mol. Biol. (1998) [Pubmed]
  5. 15N kinetic isotope effects on uncatalyzed and enzymatic deamination of cytidine. Snider, M.J., Reinhardt, L., Wolfenden, R., Cleland, W.W. Biochemistry (2002) [Pubmed]
  6. Enzymatic production of optically pure (2'R-cis)-2'-deoxy-3'-thiacytidine (3TC, lamivudine): a potent anti-HIV agent. Mahmoudian, M., Baines, B.S., Drake, C.S., Hale, R.S., Jones, P., Piercey, J.E., Montgomery, D.S., Purvis, I.J., Storer, R., Dawson, M.J. Enzyme Microb. Technol. (1993) [Pubmed]
  7. Role of glutamate-104 in generating a transition state analogue inhibitor at the active site of cytidine deaminase. Carlow, D.C., Short, S.A., Wolfenden, R. Biochemistry (1996) [Pubmed]
  8. Complementary truncations of a hydrogen bond to ribose involved in transition-state stabilization by cytidine deaminase. Carlow, D.C., Short, S.A., Wolfenden, R. Biochemistry (1998) [Pubmed]
  9. De novo synthesis of thymidylate via deoxycytidine in dcd (dCTP deaminase) mutants of Escherichia coli. Weiss, B., Wang, L. J. Bacteriol. (1994) [Pubmed]
  10. Induction of pyrimidine nucleoside metabolizing enzymes in E. coli B. Vita, A., Amici, A., Magni, G. Ital. J. Biochem. (1983) [Pubmed]
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