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Chemical Compound Review

TETRAMISOLE     7-phenyl-4-thia-1,6- diazabicyclo[3.3.0]oct...

Synonyms: Tetramisolo, tetramizole, Tetramisolum, Ascaverm (TN), CHEMBL277775, ...
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Disease relevance of Nilverm

  • Levamisole (Ketrax), and anthelmintic drug commonly used in the tropics, has been found to restore the impaired spontaneous rosette-forming lymphocytes and delayed cutaneous hypersensitivity reactions in experimentally malnourished rats [1].
  • L-tetramisole affected the production of the physiological IFN, but not the production of IFN induced by Newcastle disease virus (NDV) in the peritoneal cells of mice or in L929 cells [2].

High impact information on Nilverm


Biological context of Nilverm

  • Additionally, [gamma-32P]ATP hydrolysis by purified ALP in contrast to that by intact vesicles was completely inhibited by l-tetramisole, a specific inhibitor of ALP, suggesting a loss of specific ATPase during purification [3].

Anatomical context of Nilverm


Associations of Nilverm with other chemical compounds


  1. Effects of levamisole on the immune responses of experimentally malnourished rats. Olusi, S.O., Jessop, W.J., Shoroye, A. Pediatr. Res. (1979) [Pubmed]
  2. Influence of L-tetramisole on the interferon production by mouse peritoneal and L929 cells. Błach-Olszewska, Z., Zaczyńska, E. Arch. Immunol. Ther. Exp. (Warsz.) (1991) [Pubmed]
  3. Evidence of the presence of a specific ATPase responsible for ATP-initiated calcification by matrix vesicles isolated from cartilage and bone. Hsu, H.H., Anderson, H.C. J. Biol. Chem. (1996) [Pubmed]
  4. Effect of L- and D-tetramisole on 32Pi and 45Ca uptake and mineralization by matrix vesicle-enriched fractions from chicken epiphyseal cartilage. Register, T.C., Warner, G.P., Wuthier, R.E. J. Biol. Chem. (1984) [Pubmed]
  5. Stereospecific inhibition of alkaline phosphatase by L-tetramisole prevents in vitro cartilage calcification. Fallon, M.D., Whyte, M.P., Teitelbaum, S.L. Lab. Invest. (1980) [Pubmed]
  6. L-tetramisole. Enhancement of human lymphocyte response to antigen. Pabst, H.F., Crawford, J. Clin. Exp. Immunol. (1975) [Pubmed]
  7. Enzyme-histochemical demonstration of intralobular lymphatic vessels in the mouse thymus. Kato, S. Arch. Histol. Cytol. (1990) [Pubmed]
  8. Histochemical visualization of lymphatic capillaries in the rat: a comparison of methods demonstrated at the posterior pharyngeal surface. Werner, J.A., Schünke, M., Tillmann, B. Archivum histologicum Japonicum. Nippon soshikigaku kiroku. (1987) [Pubmed]
  9. Fate of ATP in secretory granules: phosphohydrolase studies in pancreatic vascular bed. Böck, P. Arch. Histol. Cytol. (1989) [Pubmed]
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