Disease relevance of Tiamenidine hydrochloride

• Tiamenidine, a centrally acting antihypertensive drug in essential hypertension [proceedings] [1].
• Significant tachycardia was demonstrated in all cats 15-19 h after cessation of treatment with tiamenidine with no evidence of blood pressure elevation; the tachycardia was absent 48 h after the final dose [2].
• In conscious renal hypertensive cats prepared with permanent indwelling arterial catheters oral administration of clonidine (0.05 mg x 3 daily) clonidine (0.0125 mg x 3 daily), or tiamenidine (0.25 mg x 3 daily) induced hypotension and bradycardia during 6 days of treatment, although these responses were not well sustained [2].

High impact information on Tiamenidine hydrochloride

• We have evaluated the electrophysiologic and hemodynamic effects of chronic oral treatment with either clonidine (0.2 to 0.5 mg every 12 hours; n = 7) or another centrally active alpha 2-agonist, tiamenidine (0.5 to 1.5 mg every 12 hours; n = 7), in otherwise healthy hypertensive human volunteers [3].
• Clonidine also significantly increased corrected sinus node recovery time and lowered cardiac output while similar (but statistically insignificant) trends were seen with tiamenidine [3].
• 1 Tiamenidine (Hoe 440) is an imidazoline with blood pressure lowering properties [4].
• Changes in blood pressure, plasma catecholamines and plasma renin activity during and after treatment with tiamenidine and clonidine [4].
• Changes in blood pressure, heart rate, and sympathetic activity on abrupt withdrawal of tiamenidine (HOE 440) in essential hypertension [5].

Associations of Tiamenidine hydrochloride with other chemical compounds

• In contrast blood pressure was either unaffected or elevated following i.c.v. administration of St 91, oxymetazoline and tiamenidine [6].
• Quantitative analysis of tiamenidine in human plasma by gas chromatography mass spectrometry of a dibenzyl derivative [7].
• Quantitative determination of tiamenidine hydrochloride in human serum using gas chromatography mass spectrometry [8].

Analytical, diagnostic and therapeutic context of Tiamenidine hydrochloride

• Determination of tiamenidine in biological specimens by radioimmunoassay [9].
• A gas chromatography mass spectrometry method has been developed and evaluated for the quantitative analysis of tiamenidine in plasma [7].

References