Disease relevance of Zyxorin

• Subjectively, pruritus improved in 13 of 24 on flumecinol and 10 of 26 on placebo (chi 2 = 1.24, P = 0.27) [1].
• Flumecinol for the treatment of pruritus associated with primary biliary cirrhosis [1].
• OBJECTIVE: To determine whether flumecinol (3-trifluoromethyl-alpha-ethylbenzhydrol, Zixoryn) is effective in ameliorating pruritus of cholestasis, particularly in primary bilary cirrhosis [1].

High impact information on Zyxorin

• METHODS AND RESULTS: 50 patients (46 with primary biliary cirrhosis, PBC) took oral flumecinol 600 mg or identical placebo once weekly for 3 weeks [1].
• Estimation of impurity profiles of drugs and related materials. Part 9: HPLC investigation of flumecinol [2].
• In man, RGH-3332 decreased the half-life of antipyrine and tolbutamide and increased D-glucaric acid excretion [3].
• Effect of flumecinol (Zixoryn) on the cytochrome P450 and cytochrome P448 dependent hepatic microsomal monooxygenase activities in male rats [4].
• The effect of three-day oral administration of 50 mg/kg bw. and 100 mg/kg bw. flumecinol (Zixoryn, Gedeon Richter Chemical Works Ltd., Budapest, Hungary) and intraperitoneal administration of 50 mg/kg bw. phenobarbital as well as the single intraperitoneal administration of 20 mg/kg bw [4].

Biological context of Zyxorin

• Up to a concentration of 1 mumolar, flumecinol (3-trifluoromethyl-alpha-ethyl-benzhydrol), as an enzyme inductor, significantly enhanced the rate of lipid peroxidation but above 1 molar it scarcely influenced it [5].
• Pharmacokinetics of flumecinol in rats [6].
• The mass spectrometric behaviour of six human metabolites formed by hydroxylation in various positions of the alpha-ethyl group or/and on the phenyl ring of 3-trifluoromethyl-alpha-ethyl-benzyhydrol (flumecinol) and seven related compounds has been studied [7].
• 3-Trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332). Liver enzyme induction and D-glucaric acid excretion [8].

Anatomical context of Zyxorin

• Effects of 3-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332), a new enzyme inducer on the central nervous system of rats. Part II [9].

Associations of Zyxorin with other chemical compounds

• A study was made of the lipid peroxidation in the microsomal fraction of human placenta tissue in the presence of flumecinol (Zixoryn, Gedeon Richter Pharmaceutical Works, Budapest, Hungary) [5].
• There was no change in antipyrine half-life and its apparent volume of distribution (aVd) in the amount of D-glucaric acid excreted in the urine (indirect parameters of the mixed-function monooxygenase system's activity) after 1-week administration of 1000 mg alpha-methyldopa together with 300 mg Zixoryn per day [10].

Analytical, diagnostic and therapeutic context of Zyxorin

• Two HPLC systems have been developed for the investigation of flumecinol (3-trifluoromethyl-alpha-ethyl-benzhydrol) [2].
• Flumecinol concentration in plasma was determined (0-96 h) by capillary gas-liquid chromatography [11].
• Following ovariectomy, flumecinol exerted inhibiting effect on microsomal oxydases [12].

References