Disease relevance of Mannobiose

• A mannan of Candida glabrata IFO 0622 digested by Arthrobacter exo-alpha-mannosidase and a beta-1,2-linked mannobiose obtained from the parent mannan by acid treatment was analyzed using 13C nuclear magnetic resonance spectroscopy [1].

High impact information on Mannobiose

• Null mutants of MNT1 are viable, have no apparent growth defect, and are blocked in the elongation of protein O-linked mannobiose [2].
• In the larger oligosaccharides, most of the radioactivity was in mannobiose whereas in oligosaccharide 7 most of the radioactivity was in mannose.. [3].
• Carbohydrate recognition by bovine serum conglutinin has been investigated by inhibition and direct binding assays using glycoproteins and polysaccharides from Saccharomyces cerevisiae (baker's yeast), and neoglycolipids derived from N-acetylglucosamine oligomers, mannobiose and human milk oligosaccharides [4].
• Linkages within the mannobiose and mannotriose were all alpha 1-2, as proven by gas chromatography-mass spectrometry of oligosaccharides released by beta-elimination [5].
• Fast atom bombardment-mass spectrometry, N-terminal amino acid sequencing, and alpha-mannosidase digestion demonstrated universal O glycosylation of Thr residues with a single alpha-D-Man, mannobiose, or mannotriose unit [5].

Biological context of Mannobiose

• Partial acid hydrolysis, under conditions that destroyed the antigenic determinant, released only mannose and mannobiose [6].

Anatomical context of Mannobiose

• These results suggest that mannobiose mono fatty acid esters are useful in the targeting of liposomes to Kupffer cells and other macrophages [7].

Associations of Mannobiose with other chemical compounds

• The enzyme cleaves specifically (1-->6)-linked mannobiose and has no activity towards any other linkages, p-nitrophenyl-alpha-D-mannopyranoside or baker's yeast mannan [8].
• Three-dimensional structures of the complexes of concanavalin A (ConA) with alpha(1-2) linked mannobiose, triose and tetraose have been generated with the X-ray crystal structure data on native ConA using the CCEM (contact criteria and energy minimization) method [9].
• We reinvestigated the structures of mannobiose (M(2)), M(3)s, and mannotetraose (M(4)) that were completely isolated by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) and NMR spectroscopy [10].

Gene context of Mannobiose

• The mannobiose and -triose most strongly bound to MBP-C CRD were Man alpha (1-2)Man alpha-OMe and Man alpha (1-2)Man alpha (1-6)Man alpha-OMe, respectively [11].

Analytical, diagnostic and therapeutic context of Mannobiose

• Crystallization and preliminary structural studies of Scilla campanulata lectin complexed with alpha1-6 mannobiose [12].

References