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Chemical Compound Review:

SureCN134378 [(2R,3S,4S,5S)-3,4-dihydroxy- 5...

Synonyms: CHEBI:16308, AC1L97ZQ, C02591, SUP, SUCROSE-6-PHOSHPATE, ...

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Disease relevance of Sucrose 6-phosphate

Transposon-encoded sucrose metabolism in Lactococcus lactis. Purification of sucrose-6-phosphate hydrolase and genetic linkage to N5-(L-1-carboxyethyl)-L-ornithine synthase in strain K1 [1].
Sucrose-6-phosphate hydrolase from Lactococcus lactis subsp. lactis K1-23 (formerly Streptococcus lactis K1-23) has been purified 600-fold to electrophoretic homogeneity [1].
Streptomyces hachijoensis VKM Ac-191T and Streptomyces cinnamoneus subsp. azacoluta VKM Ac-606T assigned to one genospecies on the basis of DNA--DNA hybridization [5] contain 37% of an identical sugar-1-phosphate polymer [2].
Unsubstituted 1,3-poly(glycerol phosphate) and two sugar-1-phosphate polymers were identified in the cell wall of Brevibacterium linens VKM Ac-2159 by NMR spectroscopy and chemical methods [3].

High impact information on Sucrose 6-phosphate

By contrast, purified sucrose-6-phosphate hydrolase (M(r) approximately 53,000) hydrolyzed only sucrose-6-phosphate (K(m) approximately 80 microm) [4].
Hybridization studies with oligonucleotide probes show that the genes for sucrose-6-phosphate hydrolase (scrB), Enzyme IIScr of the phosphoenolypyruvate-dependent sucrose:phosphotransferase system (scrA), and N5-(carboxyethyl)ornithine synthase (ceo) are encoded by the same approximately 20-kilobase EcoRI fragment [1].
Decreased sucrose-6-phosphate phosphatase level in transgenic tobacco inhibits photosynthesis, alters carbohydrate partitioning, and reduces growth [5].
SUH was shown to act rather specifically on sucrose (K(m) = 2.5 mM) but not on sucrose-6-phosphate [6].
TM0651 is a member of the haloacid dehalogenase (HAD) superfamily, with sequence homology to trehalose-6-phosphate phosphatase and sucrose-6(F)-phosphate phosphohydrolase [7].

Biological context of Sucrose 6-phosphate

Its deduced amino acid sequence yields a protein with a molecular mass of 57.377 kDa which shows significant homology with bacterial sucrose-6-phosphate hydrolases and sucrases [8].
Intracellular sucrose-6-phosphate hydrolase catalyzed the hydrolysis of sucrose-6-phosphate (Km = 0.17 mM), sucrose (Km = 60 mM), and raffinose (Km = 150 mM) [9].

Anatomical context of Sucrose 6-phosphate

Incubation of UDP-[14C]galactose with membranes of Bacillus coagulans led to the formation of a radioactive glycolipid, which was tentatively characterized as beta-galactosyl phosphorylpolyprenol (Gal-P-prenol) on the basis of its chromatographic behavior and data from structural analysis of its sugar 1-phosphate moiety [10].
The cell wall of Spirilliplanes yamanashiensis VKM Ac-1993(T) contains four anionic polymers, viz., three teichoic acids and a sugar-1-phosphate polymer [11].

Analytical, diagnostic and therapeutic context of Sucrose 6-phosphate

Purification, molecular cloning, and sequence analysis of sucrose-6F-phosphate phosphohydrolase from plants [12].

References

Transposon-encoded sucrose metabolism in Lactococcus lactis. Purification of sucrose-6-phosphate hydrolase and genetic linkage to N5-(L-1-carboxyethyl)-L-ornithine synthase in strain K1. Thompson, J., Nguyen, N.Y., Sackett, D.L., Donkersloot, J.A. J. Biol. Chem. (1991) [Pubmed]
Anionic carbohydrate-containing polymers of cell walls in two streptoverticille genospecies. Kozlova, Y.I., Streshinskaya, G.M., Shashkov, A.S., Evtushenko, L.I., Naumova, I.B. Biochemistry Mosc. (1999) [Pubmed]
Anionic polymers of the cell wall of Brevibacterium linens VKM Ac-2159. Potekhina, N.V., Shashkov, A.S., Streshinskaya, G.M., Senchenkova, S.N., Evtushenko, L.I. Biochemistry Mosc. (2005) [Pubmed]
Metabolism of sucrose and its five linkage-isomeric alpha-D-glucosyl-D-fructoses by Klebsiella pneumoniae. Participation and properties of sucrose-6-phosphate hydrolase and phospho-alpha-glucosidase. Thompson, J., Robrish, S.A., Immel, S., Lichtenthaler, F.W., Hall, B.G., Pikis, A. J. Biol. Chem. (2001) [Pubmed]
Decreased sucrose-6-phosphate phosphatase level in transgenic tobacco inhibits photosynthesis, alters carbohydrate partitioning, and reduces growth. Chen, S., Hajirezaei, M., Peisker, M., Tschiersch, H., Sonnewald, U., Börnke, F. Planta (2005) [Pubmed]
Molecular and functional characterization of a unique sucrose hydrolase from Xanthomonas axonopodis pv. glycines. Kim, H.S., Park, H.J., Heu, S., Jung, J. J. Bacteriol. (2004) [Pubmed]
Crystal structure of a phosphatase with a unique substrate binding domain from Thermotoga maritima. Shin, D.H., Roberts, A., Jancarik, J., Yokota, H., Kim, R., Wemmer, D.E., Kim, S.H. Protein Sci. (2003) [Pubmed]
Characterization of a sucrase gene from Staphylococcus xylosus. Brückner, R., Wagner, E., Götz, F. J. Bacteriol. (1993) [Pubmed]
Plasmid-mediated uptake and metabolism of sucrose by Escherichia coli K-12. Schmid, K., Schupfner, M., Schmitt, R. J. Bacteriol. (1982) [Pubmed]
The function of galactosyl phosphorylpolyprenol in biosynthesis of lipoteichoic acid in Bacillus coagulans. Yokoyama, K., Araki, Y., Ito, E. Eur. J. Biochem. (1988) [Pubmed]
NMR-based identification of cell wall anionic polymers of Spirilliplanes yamanashiensis VKM Ac-1993(T). Shashkov, A.S., Streshinskaya, G.M., Evtushenko, L.I., Naumova, I.B. Carbohydr. Res. (2001) [Pubmed]
Purification, molecular cloning, and sequence analysis of sucrose-6F-phosphate phosphohydrolase from plants. Lunn, J.E., Ashton, A.R., Hatch, M.D., Heldt, H.W. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]

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