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Chemical Compound Review

LFA703     [(1S,3R,7R,8S,8aS)-8-[2- [(2S,4R)-4-hydroxy...

Synonyms: AC1L9MT5, 1xdd, AAY
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Disease relevance of [(1S,3R,7R,8S,8aR)-8-[2-[(2S,4R)-4-hydroxy-1-[[5-(hydroxymethyl)-6-methoxy-naphthalen-2-yl]methyl]-6-oxo-2-piperidyl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate

  • 2. The objective of this study was to examine the anti-inflammatory mechanisms of LFA703 in ischemia/reperfusion (I/R)-induced leukocyte-endothelium interactions in the colon [1].

High impact information on [(1S,3R,7R,8S,8aR)-8-[2-[(2S,4R)-4-hydroxy-1-[[5-(hydroxymethyl)-6-methoxy-naphthalen-2-yl]methyl]-6-oxo-2-piperidyl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate


Biological context of [(1S,3R,7R,8S,8aR)-8-[2-[(2S,4R)-4-hydroxy-1-[[5-(hydroxymethyl)-6-methoxy-naphthalen-2-yl]methyl]-6-oxo-2-piperidyl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate


Anatomical context of [(1S,3R,7R,8S,8aR)-8-[2-[(2S,4R)-4-hydroxy-1-[[5-(hydroxymethyl)-6-methoxy-naphthalen-2-yl]methyl]-6-oxo-2-piperidyl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate


Associations of [(1S,3R,7R,8S,8aR)-8-[2-[(2S,4R)-4-hydroxy-1-[[5-(hydroxymethyl)-6-methoxy-naphthalen-2-yl]methyl]-6-oxo-2-piperidyl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate with other chemical compounds


Gene context of [(1S,3R,7R,8S,8aR)-8-[2-[(2S,4R)-4-hydroxy-1-[[5-(hydroxymethyl)-6-methoxy-naphthalen-2-yl]methyl]-6-oxo-2-piperidyl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate


  1. A statin-based inhibitor of lymphocyte function antigen-1 protects against ischemia/reperfusion-induced leukocyte adhesion in the colon. Wan, M.X., Schramm, R., Klintman, D., Welzenbach, K., Weitz-Schmidt, G., Thorlacius, H. Br. J. Pharmacol. (2003) [Pubmed]
  2. The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase. Schmidmaier, R., Baumann, P., Simsek, M., Dayyani, F., Emmerich, B., Meinhardt, G. Blood (2004) [Pubmed]
  3. Differential effect of LFA703, pravastatin, and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes. Takahashi, H.K., Mori, S., Iwagaki, H., Yoshino, T., Tanaka, N., Weitz-Schmidt, G., Nishibori, M. J. Leukoc. Biol. (2005) [Pubmed]
  4. Lymphocyte function antigen-1 mediates leukocyte adhesion and subsequent liver damage in endotoxemic mice. Li, X., Klintman, D., Weitz-Schmidt, G., Schramm, R., Thorlacius, H. Br. J. Pharmacol. (2004) [Pubmed]
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