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Chemical Compound Review

Cetabeno     4-(hexadecylamino)benzoic acid

Synonyms: Cetaben, Cetabenum, CHEMBL31907, Cetaben [INN], AG-F-96280, ...
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Disease relevance of Cetaben

  • The human hepatoma cell line HepG2 was used to study the effect of cetaben, a non-fibrate hypolipidemic drug, on cell morphology and vesicle distribution [1].
  • Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatoma cells and HepG2 human hepatoblastoma cells [2].
  • Cetaben caused 1 death at 200 mg/kg per day and decreases in body weight gain and food consumption at 50 mg/kg per day or more [3].

High impact information on Cetaben


Chemical compound and disease context of Cetaben


Biological context of Cetaben

  • At pH 8, the relationship between cetaben sodium solubility and surfactant concentration delineated apparent saturable kinetics; at pH 4.9, the relationship between the two parameters was linear [6].
  • 8. The results obtained suggest that cetaben represents an exceptional type of peroxisome proliferator, specifically affecting peroxisomes, without having a negative influence on the processes of peroxisome biogenesis [7].

Anatomical context of Cetaben


Associations of Cetaben with other chemical compounds


Gene context of Cetaben


  1. The hypolipidemic compound cetaben induces changes in Golgi morphology and vesicle movement. Kovacs, W.J., Schrader, M., Walter, I., Stangl, H. Histochem. Cell Biol. (2004) [Pubmed]
  2. Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatoma cells and HepG2 human hepatoblastoma cells. Kovacs, W., Walter, I., Stangl, H. Histochem. Cell Biol. (2001) [Pubmed]
  3. Cetaben versus clofibrate: comparison of toxicity and peroxisome proliferation in rats. Fort, F.L., Stein, H.H., Langenberg, K., Lewkowski, J.P., Heyman, I.A., Kesterson, J.W. Toxicology (1983) [Pubmed]
  4. Cetaben and fibrates both influence the activities of peroxisomal enzymes in different ways. Chandoga, J., Rojeková, I., Hampl, L., Hocman, G. Biochem. Pharmacol. (1994) [Pubmed]
  5. Localization of mRNAs encoding peroxisomal proteins in cell culture by non-radioactive in situ hybridization. Comparison of rat and human hepatoma cells and their responses to two divergent hypolipidemic drugs. Kovacs, W., Stangl, H., Völkl, A., Schad, A., Dariush Fahimi, H., Baumgart, E. Histochem. Cell Biol. (2001) [Pubmed]
  6. Micellar solubilization of cetaben sodium in surfactant and lipid solutions. Chow, S.L., Sims, B.E. Journal of pharmaceutical sciences. (1981) [Pubmed]
  7. Cetaben is an exceptional type of peroxisome proliferator. Chandoga, J., Hampl, L., Turecký, L., Rojeková, I., Uhliková, E., Hocman, G. Int. J. Biochem. (1994) [Pubmed]
  8. Atherosclerosis mouse model induced by a high-cholesterol diet supplemented with beta-aminopropionitrile: effects of various anti-atherosclerotic agents on the biochemical parameters. Yamaguchi, Y., Yamada, K., Kitagawa, S., Kunitomo, M. Jpn. J. Pharmacol. (1990) [Pubmed]
  9. Effects of hypolipidaemics cetaben and clofibrate on mitochondrial and peroxisomal enzymes of rat liver. Schön, H.J., Grgurin, M., Klune, G., Prager, C., Marz, R., Legenstein, E., Böck, P., Kramar, R. J. Pharm. Pharmacol. (1994) [Pubmed]
  10. Differential induction of peroxisomal enzymes by hypolipidaemics in human (HepG2) and rat (MH1C1) hepatoma cell lines. Stangl, H., Kovacs, W., Böck, P., Kremser, K. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. (1995) [Pubmed]
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