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Gene Review

Dao  -  D-amino-acid oxidase

Rattus norvegicus

Synonyms: DAAO, DAMOX, DAO, Dao1
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Disease relevance of Dao1


High impact information on Dao1

  • This study was designed to determine whether a provocative test for increasing the level of plasma DAO activity by heparin administration could be used to monitor the extent and severity of acute, severe, small intestinal mucosal injury [5].
  • Diamine oxidase (DAO; EC is an enzyme found in high activity in the mature cells of the upper villus of rat small intestinal mucosa and in very much lower activity in all other tissues in the nonpregnant rat [5].
  • Po were labeled cytochemically for either catalase, which stains them all uniformly, or for D-amino acid oxidase (DAA-OX), which gives a heterogeneous reaction with lightly and darkly stained PO [6].
  • The interconnections between Po with differing DAA-OX activities suggest that they originate from the same parent organelle [6].
  • Peroxisomal enzyme activities change to approximately 165%, 50%, 30%, and 0% of the controls for catalase, urate oxidase, L-alpha-hydroxy acid oxidase, and D-amino acid oxidase, respectively [7].

Chemical compound and disease context of Dao1


Biological context of Dao1


Anatomical context of Dao1

  • The decrease in plasma PHD activity closely reflected the length of intestinal mucosa injured (n = 128, r = 0.86, P less than 0.001), and it was much more sensitive (threshold limit of detection = 13% of total length, range = 67 U/ml for 100% length of injury) than unstimulated basal levels of plasma DAO (threshold = 40%, range = 2.1 U/ml) [5].
  • Whereas all segments of this reticulum stained homogeneously for catalase, they exhibited a marked difference in the intensity of the DAA-OX reaction [6].
  • Ornithine decarboxylase and DAO were assayed in the proximal and distal small bowel mucosa of 55 rats, starved for four days and then refed [15].
  • These data confirm the prominence of ODC in the replication processes and suggest that intestinal DAO may not play a major role in enterocyte replication [15].
  • These observations demonstrate the capability of mammalian peroxisomes to oxidize pipecolic acid and suggest that the absence or deficiency of peroxisomal D-amino acid oxidase may be implicated in the pathogenesis of hyperpipecolatemia in Zellweger's CHRS [16].

Associations of Dao1 with chemical compounds


Other interactions of Dao1


Analytical, diagnostic and therapeutic context of Dao1


  1. Functional interactions between oxidative stress, membrane Na(+) permeability, and cell volume in rat hepatoma cells. Schlenker, T., Feranchak, A.P., Schwake, L., Stremmel, W., Roman, R.M., Fitz, J.G. Gastroenterology (2000) [Pubmed]
  2. Induction of cytotoxic oxidative stress by D-alanine in brain tumor cells expressing Rhodotorula gracilis D-amino acid oxidase: a cancer gene therapy strategy. Stegman, L.D., Zheng, H., Neal, E.R., Ben-Yoseph, O., Pollegioni, L., Pilone, M.S., Ross, B.D. Hum. Gene Ther. (1998) [Pubmed]
  3. D-amino-acid oxidase is involved in D-serine-induced nephrotoxicity. Maekawa, M., Okamura, T., Kasai, N., Hori, Y., Summer, K.H., Konno, R. Chem. Res. Toxicol. (2005) [Pubmed]
  4. Endogenous D-serine is involved in induction of neuronal death by N-methyl-D-aspartate and simulated ischemia in rat cerebrocortical slices. Katsuki, H., Nonaka, M., Shirakawa, H., Kume, T., Akaike, A. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  5. Plasma postheparin diamine oxidase. Sensitive provocative test for quantitating length of acute intestinal mucosal injury in the rat. Luk, G.D., Bayless, T.M., Baylin, S.B. J. Clin. Invest. (1983) [Pubmed]
  6. Three-dimensional reconstruction of a peroxisomal reticulum in regenerating rat liver: evidence of interconnections between heterogeneous segments. Yamamoto, K., Fahimi, H.D. J. Cell Biol. (1987) [Pubmed]
  7. Structure, composition, physical properties, and turnover of proliferated peroxisomes. A study of the trophic effects of Su-13437 on rat liver. Leighton, F., Coloma, L., Koenig, C. J. Cell Biol. (1975) [Pubmed]
  8. Sodium benzoate attenuates D-serine induced nephrotoxicity in the rat. Williams, R.E., Lock, E.A. Toxicology (2005) [Pubmed]
  9. Effects of aminoguanidine and L-NAME on histamine-induced blood pressure drop in the rat. Nilsson, B.O., Kockum, I., Rosengren, E. Acta Physiol. Scand. (1997) [Pubmed]
  10. Diamine oxidase, a plasma biomarker in rats to GI tract toxicity of oral fluorouracil anti-cancer drugs. Moriyama, K., Kouchi, Y., Morinaga, H., Irimura, K., Hayashi, T., Ohuchida, A., Goto, T., Yoshizawa, Y. Toxicology (2006) [Pubmed]
  11. Effects of some hypolipidemic drugs on biochemical values and on hepatic peroxisomal enzymes of normolipemic rat. Watanabe, T., Manna, H., Suga, T. J. Pharmacobio-dyn. (1981) [Pubmed]
  12. Role of renal D-amino-acid oxidase in pharmacokinetics of D-leucine. Hasegawa, H., Matsukawa, T., Shinohara, Y., Konno, R., Hashimoto, T. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  13. Modifications in enterocyte diamine oxidase distribution induced by heparin in the rat. D'Agostino, L., Daniele, B., Pignata, S., D'Argenio, G., Mazzacca, G. Biochem. Pharmacol. (1989) [Pubmed]
  14. Gene expression of D-amino acid oxidase in cultured rat astrocytes: regional and cell type specific expression. Urai, Y., Jinnouchi, O., Kwak, K.T., Suzue, A., Nagahiro, S., Fukui, K. Neurosci. Lett. (2002) [Pubmed]
  15. Modifications in ornithine decarboxylase and diamine oxidase in small bowel mucosa of starved and refed rats. D'Agostino, L., Daniele, B., Pignata, S., Barone, M.V., D'Argenio, G., Mazzacca, G. Gut (1987) [Pubmed]
  16. Pipecolic acid is oxidized by renal and hepatic peroxisomes. Implications for Zellweger's cerebro-hepato-renal syndrome (CHRS). Zaar, K., Angermüller, S., Völkl, A., Fahimi, H.D. Exp. Cell Res. (1986) [Pubmed]
  17. Changes in D-serine levels and localization during postnatal development of the rat vestibular nuclei. Puyal, J., Martineau, M., Mothet, J.P., Nicolas, M.T., Raymond, J. J. Comp. Neurol. (2006) [Pubmed]
  18. D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors. Stevens, E.R., Esguerra, M., Kim, P.M., Newman, E.A., Snyder, S.H., Zahs, K.R., Miller, R.F. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  19. D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Schell, M.J., Molliver, M.E., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  20. Absence of diamine oxidase activity from rabbit and rat lungs. Rao, S.B., Rao, K.S., Mehendale, H.M. Biochem. J. (1986) [Pubmed]
  21. Antioxidant enzymes in the brain of zitter rats: abnormal metabolism of oxygen species and its relevance to pathogenic changes in the brain of zitter rats with genetic spongiform encephalopathy. Gomi, H., Ueno, I., Yamanouchi, K. Brain Res. (1994) [Pubmed]
  22. D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Mothet, J.P., Parent, A.T., Wolosker, H., Brady, R.O., Linden, D.J., Ferris, C.D., Rogawski, M.A., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  23. In vivo hydrogen peroxide production in rat remnant kidney. Van den Branden, C., Vamecq, J., Verbeelen, D., Roels, F. Renal physiology and biochemistry. (1994) [Pubmed]
  24. Postnatal development and isolation of peroxisomes from brain. Lazo, O., Singh, A.K., Singh, I. J. Neurochem. (1991) [Pubmed]
  25. Cellular distribution of D-serine, serine racemase and D-amino acid oxidase in the rat vestibular sensory epithelia. Dememes, D., Mothet, J.P., Nicolas, M.T. Neuroscience (2006) [Pubmed]
  26. Immunocytochemical evidence suggesting that diamine oxidase catalyzes biosynthesis of gamma-aminobutyric acid in antropyloric gastrin cells. Hardt, J., Larsson, L.I., Hougaard, D.M. J. Histochem. Cytochem. (2000) [Pubmed]
  27. Immunoelectron microscopic study of a new D-amino acid oxidase-immunoreactive subcompartment in rat liver peroxisomes. Usuda, N., Yokota, S., Ichikawa, R., Hashimoto, T., Nagata, T. J. Histochem. Cytochem. (1991) [Pubmed]
  28. Immunocytochemical localization of D-amino acid oxidase in the central clear matrix of rat kidney peroxisomes. Usuda, N., Yokota, S., Hashimoto, T., Nagata, T. J. Histochem. Cytochem. (1986) [Pubmed]
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