Gene Review:
Uox - urate oxidase
Rattus norvegicus
Synonyms:
UOX-2, Urate oxidase, Uri, Uri2, Uricase
- Rat urate oxidase produced by recombinant baculovirus expression: formation of peroxisome crystalloid core-like structures. Alvares, K., Widrow, R.J., Abu-Jawdeh, G.M., Schmidt, J.V., Yeldandi, A.V., Rao, M.S., Reddy, J.K. Proc. Natl. Acad. Sci. U.S.A. (1992)
- A role for uric acid in the progression of renal disease. Kang, D.H., Nakagawa, T., Feng, L., Watanabe, S., Han, L., Mazzali, M., Truong, L., Harris, R., Johnson, R.J. J. Am. Soc. Nephrol. (2002)
- Hyperuricemia exacerbates chronic cyclosporine nephropathy. Mazzali, M., Kim, Y.G., Suga, S., Gordon, K.L., Kang, D.H., Jefferson, J.A., Hughes, J., Kivlighn, S.D., Lan, H.Y., Johnson, R.J. Transplantation (2001)
- Functional expression and peroxisomal targeting of rat urate oxidase in monkey kidney cells. Yeldandi, A.V., Chu, R., Reddy, S.K., Pan, J., Usuda, N., Lin, Y., Rao, M.S., Reddy, J.K. Gene Expr. (1995)
- Experimental meningitis in the rat: protection by uric acid at human physiological blood concentrations. Kastenbauer, S., Koedel, U., Becker, B.F., Pfister, H.W. Eur. J. Pharmacol. (2001)
- Induction and origin of hepatocytes in rat pancreas. Reddy, J.K., Rao, M.S., Qureshi, S.A., Reddy, M.K., Scarpelli, D.G., Lalwani, N.D. J. Cell Biol. (1984)
- Structure, composition, physical properties, and turnover of proliferated peroxisomes. A study of the trophic effects of Su-13437 on rat liver. Leighton, F., Coloma, L., Koenig, C. J. Cell Biol. (1975)
- Biogenesis of peroxisomes: intracellular site of synthesis of catalase and uricase. Goldman, B.M., Blobel, G. Proc. Natl. Acad. Sci. U.S.A. (1978)
- Alterations of renal function during dietary-induced hyperuricemia in the rat. Spencer, H.W., Yarger, W.E., Robinson, R.R. Kidney Int. (1976)
- Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. Osada, Y., Tsuchimoto, M., Fukushima, H., Takahashi, K., Kondo, S., Hasegawa, M., Komoriya, K. Eur. J. Pharmacol. (1993)
- Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors. Ishibuchi, S., Morimoto, H., Oe, T., Ikebe, T., Inoue, H., Fukunari, A., Kamezawa, M., Yamada, I., Naka, Y. Bioorg. Med. Chem. Lett. (2001)
- Degradation of low molecular weight uremic solutes by oral delivery of encapsulated enzymes. O'Loughlin, J.A., Bruder, J.M., Lysaght, M.J. ASAIO journal (American Society for Artificial Internal Organs : 1992) (2004)
- Regulation of purine nucleotide metabolism in hypoxic liver and intestine of rats: radical scavenging effects of allopurinol and oxypurinol. Gerber, G., Siems, W., Werner, A., Stoesser, R., Foeldes-Papp, Z., Kowalewski, J., Schneider, W., Grune, T. Adv. Exp. Med. Biol. (1989)
- Cloning and sequence analysis of cDNA for rat liver uricase. Motojima, K., Kanaya, S., Goto, S. J. Biol. Chem. (1988)
- Structural analysis of the gene encoding rat uricase. Ito, M., Nakamura, M., Ogawa, H., Kato, S., Takagi, Y. Genomics (1991)
- Organization of rat uricase chromosomal gene differs greatly from that of the corresponding plant gene. Motojima, K., Goto, S. FEBS Lett. (1990)
- Nucleotide sequence of cDNA and predicted amino acid sequence of rat liver uricase. Ito, M., Suzuki, M., Takagi, Y. Eur. J. Biochem. (1988)
- Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene. Varanasi, U., Chu, R., Huang, Q., Castellon, R., Yeldandi, A.V., Reddy, J.K. J. Biol. Chem. (1996)
- Isolation and immunolocalization of a rat renal cortical membrane urate transporter. Knorr, B.A., Lipkowitz, M.S., Potter, B.J., Masur, S.K., Abramson, R.G. J. Biol. Chem. (1994)
- Localization of urate oxidase in the crystalline cores of rat liver peroxisomes by immunocytochemistry and immunoblotting. Völkl, A., Baumgart, E., Fahimi, H.D. J. Histochem. Cytochem. (1988)
- Isolation and sequence determination of a cDNA clone for rat peroxisomal urate oxidase: liver-specific expression in the rat. Reddy, P.G., Nemali, M.R., Reddy, M.K., Reddy, M.N., Yuan, P.M., Yuen, S., Laffler, T.G., Shiroza, T., Kuramitsu, H.K., Usuda, N. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Identification of an amino acid residue involved in the substrate-binding site of rat liver uricase by site-directed mutagenesis. Ito, M., Kato, S., Nakamura, M., Go, M., Takagi, Y. Biochem. Biophys. Res. Commun. (1992)
- NO2 reactive absorption substrates in rat pulmonary surface lining fluids. Postlethwait, E.M., Langford, S.D., Jacobson, L.M., Bidani, A. Free Radic. Biol. Med. (1995)
- Rat urate oxidase: cloning and structural analysis of the gene and 5'-flanking region. Wang, X.D., Kawano, H., Alvares, K., Reddy, P.G., Getto, H., Rao, M.S., Reddy, J.K. Gene (1991)
- Postnatal development of peroxisomal and mitochondrial enzymes in rat liver. Krahling, J.B., Gee, R., Gauger, J.A., Tolbert, N.E. J. Cell. Physiol. (1979)
- Hypouricemic and uricosuric actions of AA-193 in a hyperuricemic rat model. Dan, T., Yoneya, T., Onoma, M., Onuma, E., Ozawa, K. Metab. Clin. Exp. (1994)
- Microarray analysis of gene expression in rat hippocampus after chronic ethanol treatment. Saito, M., Smiley, J., Toth, R., Vadasz, C. Neurochem. Res. (2002)
- Morphological and functional modifications of rat liver peroxisomal subpopulations during cold exposure. Goglia, F., Liverini, G., Lanni, A., Iossa, S., Barletta, A. Experimental biology. (1989)