Disease relevance of estradiol cypionate

• Eighty-four Holstein cows were utilized to evaluate effects of dry period (60 d vs. 30 d), with or without estradiol cypionate (ECP) injections to accelerate mammary involution, on prepartum and postpartum dry matter intake (DMI), body weight (BW), body condition score (BCS), and subsequent milk yield (MY) [1].

High impact information on estradiol cypionate

• The objectives of these studies were to evaluate the influence of testosterone propionate (TP), estradiol cypionate (EC), dihydrotestosterone propionate (DHTP), EC + TP, EC + DHTP, and TP + DHTP on traits of masculine sexual behavior in castrated adult male pigs of different breeds [2].
• In the Heatsynch group, all cows (n=288) received 0.5 mg of estradiol cypionate (ECP) 24 h after third PGF(2alpha) and HAI cows (n=172) were bred on standing estrus and FTAI cows (n=116) that were not observed in estrus, received TAI 72 h after the third PGF(2alpha) [3].
• Cows in diestrus were assigned either to the GnRH group (PGF2alpha on day 0, GnRH on day 2 and TAI 16 h later, n = 238) or the estradiol cypionate (ECP) group (PGF2alpha on day 0, ECP on day 1, and TAI 36 h later, n = 229) [4].
• Cows in metestrus were assigned to the Modified Heatsynch Group (GnRH on day 0, PGF(2alpha) on day 7, ECP on day 8 and TAI on day 9, n = 35) [4].
• For cows in diestrus, there were no differences in pregnancy rates on days 30, 55 and 90 for cows in the GnRH (27.5, 26.5 and 24.2%) or ECP (29.1, 25.5 and 24.1%) groups [4].

Biological context of estradiol cypionate

• Effects of estradiol cypionate (ECP) on ovarian follicular dynamics, synchrony of ovulation, and fertility in CIDR-based, fixed-time AI programs in beef heifers [5].
• On d 10, more ECP- than GnRH-treated females were inseminated after detected estrus (24 vs. 6%) [6].
• Treatments were arranged in a 3 x 2 x 2 factorial design that included dry period (30 d dry, 30 d dry + ECP, and 60 d dry), prepartum and postpartum bovine somatotropin (bST; 10.2 mg/d), and prepartum anionic or cationic diets [1].
• Use of ECP to induce ovulation was an alternative to GnRH in which greater uterine tone, ease of insemination and occurrence of estrus, improved acceptance by inseminators [7].

Anatomical context of estradiol cypionate

• Delayed first injection of the once-a-month injectable contraceptive containing 25 mg medroxyprogesterone acetate and 5 mg estradiol-cypionate: effects on cervical mucus [8].

Associations of estradiol cypionate with other chemical compounds

• Cows in metestrus were assigned either to Ovsynch (n = 68), Heatsynch (GnRH day 0, PGF2alpha day 7, ECP day 8, AIDE day 9, or TAI day 10; n = 62), or GnRH + Ovsynch (GnRH on day 0, followed by Ovsynch on day 8; n = 64) [9].

References