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Chemical Compound Review

DHTP     [(5S,8R,9S,10S,13S,14S,17S)- 10,13-dimethyl...

Synonyms: SureCN1316924, LS-19411, BRN 2628403, AC1L21IL, 855-22-1, ...
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Disease relevance of Dihydrotestosterone propionate

  • The nonaromatizable androgen, DHTP, does not reduce weight gain even in very high doses, and concurrent progesterone injections reverse the weight-reducing actions of high TP doses [1].
  • Unlike TP, the two doses of DHTP were equally effective, but neither dose of DHTP was as effective as the low dose of TP in stimulating protein and carbohydrate intake and body weight gain [2].

High impact information on Dihydrotestosterone propionate

  • CRH hnRNA expression increased significantly in the PVN in response to restraint stress, and this increase was augmented by EB treatment, but decreased by DHTP treatment [3].
  • To determine whether this impairment was due to a lack of activation of sexual behavior by estradiol, we studied here male coital behavior as well as olfactory investigation of sexually relevant odors in male ArKO mice following adult treatment with estradiol benzoate (EB) or dihydrotestosterone propionate (DHTP) [4].
  • Growth of ventral prostate and seminal vesicle was induced by the subcutaneous injection of testosterone propionate (TP) in the castrated young rats and was reduced by FK143 administration at doses above 3.2 mg/kg, while growth induced by 5 alpha-dihydrotestosterone propionate (DHTP) was not affected [5].
  • In castrated rats both NMDAR1 mRNA and [125I]MK-801 binding are significantly decreased in the lateral septum compared to castrate rats treated with DHTP, a non-aromatizable androgen [6].
  • Treatment with DHTP was ineffective for stimulation of sexual behavior; thus, it is suggested that testosterone promotes some aspects of masculine sexual behavior in male pigs via aromatization to estrogen, but both androgen and estrogen are required for maintenance of the full complement of masculine sexual behavior traits [7].

Biological context of Dihydrotestosterone propionate


Anatomical context of Dihydrotestosterone propionate


Associations of Dihydrotestosterone propionate with other chemical compounds

  • Three groups of 5 prepubertally castrated boars received twice weekly subcutaneous injections from 16 to 28 weeks of age of 5 alpha-dihydrotestosterone propionate (1 mg/kg), oestradiol-17 beta dipropionate (0.1 mg/kg), or a combination of the two steroids [11].
  • These sexually experienced males showed a marked reduction in ultrasound production after castration but significantly increased ultrasound production after daily treatment with either TP (50 micrograms or 200 micrograms), DHTP (50 micrograms or 200 micrograms) or 2 micrograms of EB [12].

Analytical, diagnostic and therapeutic context of Dihydrotestosterone propionate

  • The DHTP treatment resulted in increases in body size that were not different from those seen following TP treatment [9].


  1. Androgenic control of food intake and body weight in male rats. Gentry, R.T., Wade, G.N. Journal of comparative and physiological psychology. (1976) [Pubmed]
  2. Effects of androgens on dietary self-selection and carcass composition in male rats. Siegel, L.I., Nunez, A.A., Wade, G.N. Journal of comparative and physiological psychology. (1981) [Pubmed]
  3. Androgen inhibits, while oestrogen enhances, restraint-induced activation of neuropeptide neurones in the paraventricular nucleus of the hypothalamus. Lund, T.D., Munson, D.J., Haldy, M.E., Handa, R.J. J. Neuroendocrinol. (2004) [Pubmed]
  4. Restoration of male sexual behavior by adult exogenous estrogens in male aromatase knockout mice. Bakker, J., Honda, S., Harada, N., Balthazart, J. Hormones and behavior. (2004) [Pubmed]
  5. FK143, a novel nonsteroidal inhibitor of steroid 5 alpha-reductase: (2) In vivo effects on rat and dog prostates. Hirosumi, J., Nakayama, O., Chida, N., Inami, M., Fagan, T., Sawada, K., Shigematsu, S., Kojo, H., Notsu, Y., Okuhara, M. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  6. Distribution of NMDAR1 receptor subunit mRNA and [125I]MK-801 binding in the hypothalamus of intact, castrate and castrate-DHTP treated male rats. Kus, L., Handa, R.J., Sanderson, J.J., Kerr, J.E., Beitz, A.J. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  7. The influence of androgenic and estrogenic hormones on sexual behavior in castrated adult male pigs. Levis, D.G., Ford, J.J. Hormones and behavior. (1989) [Pubmed]
  8. Contrasting effects of pre- and posthatch exposure to gonadal steroids on the development of vocal, sexual, and aggressive behavior of young domestic fowl. Clifton, P.G., Andrew, R.J. Hormones and behavior. (1989) [Pubmed]
  9. Androgenic influences on body size and composition of adult rhesus monkeys. Kemnitz, J.W., Sladky, K.K., Flitsch, T.J., Pomerantz, S.M., Goy, R.W. Am. J. Physiol. (1988) [Pubmed]
  10. Endocrine correlates of meiosis in the male rat. Clausen, O.P., Purvis, K., Hansson, V. Arch. Androl. (1979) [Pubmed]
  11. Behavioural and morphological effects of 5 alpha-dihydrotestosterone and oestradiol-17 beta in the prepubertally castrated boar. Parrott, R.F., Booth, W.D. J. Reprod. Fertil. (1984) [Pubmed]
  12. Courtship ultrasonic vocalizations in male Swiss-Webster mice: effects of hormones and sexual experience. Nunez, A.A., Tan, D.T. Physiol. Behav. (1984) [Pubmed]
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