Disease relevance of Dihydrotestosterone propionate

• The nonaromatizable androgen, DHTP, does not reduce weight gain even in very high doses, and concurrent progesterone injections reverse the weight-reducing actions of high TP doses [1].
• Unlike TP, the two doses of DHTP were equally effective, but neither dose of DHTP was as effective as the low dose of TP in stimulating protein and carbohydrate intake and body weight gain [2].

High impact information on Dihydrotestosterone propionate

• CRH hnRNA expression increased significantly in the PVN in response to restraint stress, and this increase was augmented by EB treatment, but decreased by DHTP treatment [3].
• To determine whether this impairment was due to a lack of activation of sexual behavior by estradiol, we studied here male coital behavior as well as olfactory investigation of sexually relevant odors in male ArKO mice following adult treatment with estradiol benzoate (EB) or dihydrotestosterone propionate (DHTP) [4].
• Growth of ventral prostate and seminal vesicle was induced by the subcutaneous injection of testosterone propionate (TP) in the castrated young rats and was reduced by FK143 administration at doses above 3.2 mg/kg, while growth induced by 5 alpha-dihydrotestosterone propionate (DHTP) was not affected [5].
• In castrated rats both NMDAR1 mRNA and [125I]MK-801 binding are significantly decreased in the lateral septum compared to castrate rats treated with DHTP, a non-aromatizable androgen [6].
• Treatment with DHTP was ineffective for stimulation of sexual behavior; thus, it is suggested that testosterone promotes some aspects of masculine sexual behavior in male pigs via aromatization to estrogen, but both androgen and estrogen are required for maintenance of the full complement of masculine sexual behavior traits [7].

Biological context of Dihydrotestosterone propionate

• Prehatch treatment with 5 alpha-dihydrotestosterone propionate (DHTP) reduces later testosterone-facilitated aggressive behavior and produces greatly enhanced avoidance that interferes with sexual behavior in some test situations [8].
• Increased body size induced by TP and DHTP was accomplished without reliable increases in food intake [9].
• A combined treatment with FSH and dihydrotestosterone propionate (DHTP) resulted in a premature start of Sertoli cell secretion of ABP into the epididymis, but in a normal appearance of haploid and tetraploid cells [10].

Anatomical context of Dihydrotestosterone propionate

• NMDAR1 mRNA was also significantly decreased in the supraoptic nucleus of castrate rats when compared to castrate rats treated with DHTP [6].

Associations of Dihydrotestosterone propionate with other chemical compounds

• Three groups of 5 prepubertally castrated boars received twice weekly subcutaneous injections from 16 to 28 weeks of age of 5 alpha-dihydrotestosterone propionate (1 mg/kg), oestradiol-17 beta dipropionate (0.1 mg/kg), or a combination of the two steroids [11].
• These sexually experienced males showed a marked reduction in ultrasound production after castration but significantly increased ultrasound production after daily treatment with either TP (50 micrograms or 200 micrograms), DHTP (50 micrograms or 200 micrograms) or 2 micrograms of EB [12].

Analytical, diagnostic and therapeutic context of Dihydrotestosterone propionate

• The DHTP treatment resulted in increases in body size that were not different from those seen following TP treatment [9].

References