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Chemical Compound Review

Decumbin     (1R,2S,3E,7S,11E,13R,15S)- 2,15-dihydroxy-7...

Synonyms: Cyanaein, Ascotoxin, Cyanein, Nectrolide, Synergisidin, ...
 
 
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High impact information on brefeldin A

  • Both PIN1 localization and auxin transport are also sensitive to BFA [1].
  • We engineered a BFA-resistant version of GNOM [1].
  • Similar to aux1 mutants, the vesicle trafficking inhibitor brefeldin A (BFA) interferes with polar hair initiation, and AUX1 function is required for BFA-mediated polarity changes [2].
  • The addition of PA reversed the inhibition of MAPK activation by BFA [3].
  • PA addition reversed the effects of BFA on Raf-1 translocation [3].
 

Biological context of brefeldin A

 

Anatomical context of brefeldin A

  • Real time imaging analysis showed that insulin induced Raf-1 translocation to cell membranes by a process that was inhibited by BFA [3].
  • BFA, however, caused substantial alterations to the arrangement of actin filaments and ER, including a characteristic accumulation of actin in the perinuclear cytoplasm [4].

References

  1. The Arabidopsis GNOM ARF-GEF mediates endosomal recycling, auxin transport, and auxin-dependent plant growth. Geldner, N., Anders, N., Wolters, H., Keicher, J., Kornberger, W., Muller, P., Delbarre, A., Ueda, T., Nakano, A., Jürgens, G. Cell (2003) [Pubmed]
  2. Cell polarity signaling in Arabidopsis involves a BFA-sensitive auxin influx pathway. Grebe, M., Friml, J., Swarup, R., Ljung, K., Sandberg, G., Terlou, M., Palme, K., Bennett, M.J., Scheres, B. Curr. Biol. (2002) [Pubmed]
  3. Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway. Rizzo, M.A., Shome, K., Vasudevan, C., Stolz, D.B., Sung, T.C., Frohman, M.A., Watkins, S.C., Romero, G. J. Biol. Chem. (1999) [Pubmed]
  4. Do phytotropins inhibit auxin efflux by impairing vesicle traffic? Petrásek, J., Cerná, A., Schwarzerová, K., Elckner, M., Morris, D.A., Zazímalová, E. Plant Physiol. (2003) [Pubmed]
 
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