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Gene Review

Arf1  -  ADP-ribosylation factor 1

Rattus norvegicus

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Disease relevance of Arf1


High impact information on Arf1

  • We now report that ARF is also required for the binding of the AP-1 adaptor protein of clathrin-coated vesicles to Golgi membranes [5].
  • The small GTP-binding protein, ADP-ribosylation factor (ARF), has previously been shown to mediate the binding to Golgi membranes of the coatomer of non-cathrin-coated (COP-coated) vesicles [5].
  • Studies of ARF binding to isolated Golgi membranes gave similar results [6].
  • Receptor and protein kinase C-mediated regulation of ARF binding to the Golgi complex [6].
  • In contrast, PKC downregulation and PKC inhibition abolished the activity of GTP and fluoroaluminae in promoting ARF binding to the Golgi complex [6].

Chemical compound and disease context of Arf1

  • The ARF signalling inhibitor brefeldin A, protein tyrosine kinase inhibitors and the Rho-inactivating toxin B of Clostridium difficile blunted alpha(1)AR-induced PLD stimulation and largely reduced the cellular PIP(2) content [7].

Biological context of Arf1


Anatomical context of Arf1


Associations of Arf1 with chemical compounds


Physical interactions of Arf1


Regulatory relationships of Arf1


Other interactions of Arf1


Analytical, diagnostic and therapeutic context of Arf1


  1. Synergistic activation of rat brain phospholipase D by ADP-ribosylation factor and rhoA p21, and its inhibition by Clostridium botulinum C3 exoenzyme. Kuribara, H., Tago, K., Yokozeki, T., Sasaki, T., Takai, Y., Morii, N., Narumiya, S., Katada, T., Kanaho, Y. J. Biol. Chem. (1995) [Pubmed]
  2. Mastoparan selectively activates phospholipase D2 in cell membranes. Chahdi, A., Choi, W.S., Kim, Y.M., Beaven, M.A. J. Biol. Chem. (2003) [Pubmed]
  3. Nuclear ADP-ribosylation factor (ARF)- and oleate-dependent phospholipase D (PLD) in rat liver cells. Increases of ARF-dependent PLD activity in regenerating liver cells. Banno, Y., Tamiya-Koizumi, K., Oshima, H., Morikawa, A., Yoshida, S., Nozawa, Y. J. Biol. Chem. (1997) [Pubmed]
  4. Enhanced levels of oleate-dependent and Arf-dependent phospholipase D isoforms in experimental colon cancer. Yoshida, M., Okamura, S., Kodaki, T., Mori, M., Yamashita, S. Oncol. Res. (1998) [Pubmed]
  5. The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein. Stamnes, M.A., Rothman, J.E. Cell (1993) [Pubmed]
  6. Receptor and protein kinase C-mediated regulation of ARF binding to the Golgi complex. De Matteis, M.A., Santini, G., Kahn, R.A., Di Tullio, G., Luini, A. Nature (1993) [Pubmed]
  7. Signalling components involved in the coupling of alpha 1-adrenoceptors to phospholipase D in neonatal rat cardiac myocytes. Gosau, N., Fahimi-Vahid, M., Michalek, C., Schmidt, M., Wieland, T. Naunyn Schmiedebergs Arch. Pharmacol. (2002) [Pubmed]
  8. ADP-ribosylation factors in rat parotid acinar cells. Dohke, Y., Hara-Yokoyama, M., Fujita-Yoshigaki, J., Furuyama, S., Sugiya, H. European journal of morphology. (1998) [Pubmed]
  9. Sorting of Golgi resident proteins into different subpopulations of COPI vesicles: a role for ArfGAP1. Lanoix, J., Ouwendijk, J., Stark, A., Szafer, E., Cassel, D., Dejgaard, K., Weiss, M., Nilsson, T. J. Cell Biol. (2001) [Pubmed]
  10. Peroxisome biogenesis: involvement of ARF and coatomer. Passreiter, M., Anton, M., Lay, D., Frank, R., Harter, C., Wieland, F.T., Gorgas, K., Just, W.W. J. Cell Biol. (1998) [Pubmed]
  11. Two distinct populations of ARF bound to Golgi membranes. Helms, J.B., Palmer, D.J., Rothman, J.E. J. Cell Biol. (1993) [Pubmed]
  12. Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway. Rizzo, M.A., Shome, K., Vasudevan, C., Stolz, D.B., Sung, T.C., Frohman, M.A., Watkins, S.C., Romero, G. J. Biol. Chem. (1999) [Pubmed]
  13. Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi. Niu, T.K., Pfeifer, A.C., Lippincott-Schwartz, J., Jackson, C.L. Mol. Biol. Cell (2005) [Pubmed]
  14. Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ. El-Annan, J., Brown, D., Breton, S., Bourgoin, S., Ausiello, D.A., Marshansky, V. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  15. Binding and functions of ADP-ribosylation factor on mammalian and yeast peroxisomes. Lay, D., L Grosshans, B., Heid, H., Gorgas, K., Just, W.W. J. Biol. Chem. (2005) [Pubmed]
  16. The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. Mukherjee, S., Gurevich, V.V., Jones, J.C., Casanova, J.E., Frank, S.R., Maizels, E.T., Bader, M.F., Kahn, R.A., Palczewski, K., Aktories, K., Hunzicker-Dunn, M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  17. Role of ADP ribosylation factor 1 in the assembly and secretion of ApoB-100-containing lipoproteins. Asp, L., Magnusson, B., Rutberg, M., Li, L., Borén, J., Olofsson, S.O. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
  18. Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF. Helms, J.B., Rothman, J.E. Nature (1992) [Pubmed]
  19. Activated ADP-ribosylation factor assembles distinct pools of actin on golgi membranes. Fucini, R.V., Navarrete, A., Vadakkan, C., Lacomis, L., Erdjument-Bromage, H., Tempst, P., Stamnes, M. J. Biol. Chem. (2000) [Pubmed]
  20. ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat. Yang, J.S., Lee, S.Y., Gao, M., Bourgoin, S., Randazzo, P.A., Premont, R.T., Hsu, V.W. J. Cell Biol. (2002) [Pubmed]
  21. Synaptojanin inhibition of phospholipase D activity by hydrolysis of phosphatidylinositol 4,5-bisphosphate. Chung, J.K., Sekiya, F., Kang, H.S., Lee, C., Han, J.S., Kim, S.R., Bae, Y.S., Morris, A.J., Rhee, S.G. J. Biol. Chem. (1997) [Pubmed]
  22. Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Cao, H., Weller, S., Orth, J.D., Chen, J., Huang, B., Chen, J.L., Stamnes, M., McNiven, M.A. Nat. Cell Biol. (2005) [Pubmed]
  23. Analysis of the interaction between cytohesin 2 and IPCEF1. Venkateswarlu, K. Meth. Enzymol. (2005) [Pubmed]
  24. ADP-ribosylation factor-directed GTPase-activating protein. Purification and partial characterization. Makler, V., Cukierman, E., Rotman, M., Admon, A., Cassel, D. J. Biol. Chem. (1995) [Pubmed]
  25. Kinetic analysis of a mammalian phospholipase D: allosteric modulation by monomeric GTPases, protein kinase C, and polyphosphoinositides. Henage, L.G., Exton, J.H., Brown, H.A. J. Biol. Chem. (2006) [Pubmed]
  26. Translocation of Arf1 to the secretory granules in rat parotid acinar cells. Dohke, Y., Hara-Yokoyama, M., Fujita-Yoshigaki, J., Kahn, R.A., Kanaho, Y., Hashimoto, S., Sugiya, H., Furuyama, S. Arch. Biochem. Biophys. (1998) [Pubmed]
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