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Gene Review

RARB  -  retinoic acid receptor, beta

Homo sapiens

Synonyms: HAP, HBV-activated protein, MCOPS12, NR1B2, Nuclear receptor subfamily 1 group B member 2, ...
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Disease relevance of RARB


High impact information on RARB


Chemical compound and disease context of RARB


Biological context of RARB


Anatomical context of RARB


Associations of RARB with chemical compounds


Physical interactions of RARB

  • RARbeta ligand-binding domain bound to an SRC-1 co-activator peptide: purification, crystallization and preliminary X-ray diffraction analysis [24].
  • RAR alpha strongly interacts with SMRT and can repress target gene transcription, whereas RAR beta and -gamma interact with SMRT only weakly and fail to repress [25].
  • Nuclear extracts prepared from COS-1 cells transfected with an expression vector for the nuclear RA receptors RAR alpha or RAR beta were enriched (20- to 100-fold) with a RA-binding activity that coeluted by size-exclusion HPLC with the putative RAR from HL-60 cells [26].
  • By mutation analysis, we demonstrate that the effect of COUP-TF requires its binding to a DR-8 element present in the RARbeta promoter [27].
  • Overexpressed BTG2 increases PRMT1 participation in the RARalpha protein complex on the RARbeta promoter, a target gene model, and enhances gene-specific histone H4 arginine methylation [28].

Regulatory relationships of RARB


Other interactions of RARB


Analytical, diagnostic and therapeutic context of RARB


  1. Lack of correlation between expression of retinoic acid receptor-beta and loss of heterozygosity on chromosome band 3p24 in esophageal cancer. Qiu, H., Lotan, R., Lippman, S.M., Xu, X.C. Genes Chromosomes Cancer (2000) [Pubmed]
  2. Evidence for impaired retinoic acid receptor-thyroid hormone receptor AF-2 cofactor activity in human lung cancer. Moghal, N., Neel, B.G. Mol. Cell. Biol. (1995) [Pubmed]
  3. Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells. James, S.Y., Lin, F., Kolluri, S.K., Dawson, M.I., Zhang, X.K. Cancer Res. (2003) [Pubmed]
  4. Inappropriate retinoic acid receptor-beta expression in oral dysplasias: correlation with acquisition of the immortal phenotype. McGregor, F., Wagner, E., Felix, D., Soutar, D., Parkinson, K., Harrison, P.R. Cancer Res. (1997) [Pubmed]
  5. Overexpression of the retinoic acid receptor gamma directly induces terminal differentiation of human embryonal carcinoma cells. Moasser, M.M., Reuter, V.E., Dmitrovsky, E. Oncogene (1995) [Pubmed]
  6. Histone deacetylase inhibitors regulate retinoic acid receptor beta expression in neuroblastoma cells by both transcriptional and posttranscriptional mechanisms. De los Santos, M., Zambrano, A., Sánchez-Pacheco, A., Aranda, A. Mol. Endocrinol. (2007) [Pubmed]
  7. Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin. Lotan, R., Xu, X.C., Lippman, S.M., Ro, J.Y., Lee, J.S., Lee, J.J., Hong, W.K. N. Engl. J. Med. (1995) [Pubmed]
  8. Cooperativity in transactivation between retinoic acid receptor and TFIID requires an activity analogous to E1A. Berkenstam, A., Ruiz, M.M., Barettino, D., Horikoshi, M., Stunnenberg, H.G. Cell (1992) [Pubmed]
  9. All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs. Durand, B., Saunders, M., Leroy, P., Leid, M., Chambon, P. Cell (1992) [Pubmed]
  10. Expression and up-regulation of retinoic acid receptor-beta is associated with retinoid sensitivity and colony formation in esophageal cancer cell lines. Xu, X.C., Liu, X., Tahara, E., Lippman, S.M., Lotan, R. Cancer Res. (1999) [Pubmed]
  11. A retinoic acid receptor beta/gamma-selective prodrug (tazarotene) plus a retinoid X receptor ligand induces extracellular signal-regulated kinase activation, retinoblastoma hypophosphorylation, G0 arrest, and cell differentiation. Yen, A., Fenning, R., Chandraratna, R., Walker, P., Varvayanis, S. Mol. Pharmacol. (2004) [Pubmed]
  12. Expression of retinoic acid receptor beta in human renal cell carcinomas correlates with sensitivity to the antiproliferative effects of 13-cis-retinoic acid. Hoffman, A.D., Engelstein, D., Bogenrieder, T., Papandreou, C.N., Steckelman, E., Dave, A., Motzer, R.J., Dmitrovsky, E., Albino, A.P., Nanus, D.M. Clin. Cancer Res. (1996) [Pubmed]
  13. Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy. Fang, M.Z., Chen, D., Sun, Y., Jin, Z., Christman, J.K., Yang, C.S. Clin. Cancer Res. (2005) [Pubmed]
  14. Rexinoid-induced expression of IGFBP-6 requires RARbeta-dependent permissive cooperation of retinoid receptors and AP-1. Uray, I.P., Shen, Q., Seo, H.S., Kim, H., Lamph, W.W., Bissonnette, R.P., Brown, P.H. J. Biol. Chem. (2009) [Pubmed]
  15. Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes. Mattei, M.G., Rivière, M., Krust, A., Ingvarsson, S., Vennström, B., Islam, M.Q., Levan, G., Kautner, P., Zelent, A., Chambon, P. Genomics (1991) [Pubmed]
  16. Methylation of multiple genes in prostate cancer and the relationship with clinicopathological features of disease. Singal, R., Ferdinand, L., Reis, I.M., Schlesselman, J.J. Oncol. Rep. (2004) [Pubmed]
  17. Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Zelent, A., Krust, A., Petkovich, M., Kastner, P., Chambon, P. Nature (1989) [Pubmed]
  18. Retinoic acid receptor beta and telomerase catalytic subunit expression in bronchial epithelium of heavy smokers. Soria, J.C., Xu, X., Liu, D.D., Lee, J.J., Kurie, J., Morice, R.C., Khuri, F., Mao, L., Hong, W.K., Lotan, R. J. Natl. Cancer Inst. (2003) [Pubmed]
  19. Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells. Li, Y., Hashimoto, Y., Agadir, A., Kagechika, H., Zhang, X. J. Biol. Chem. (1999) [Pubmed]
  20. Cellular aging and transformation suppression: a role for retinoic acid receptor beta 2. Lee, X., Si, S.P., Tsou, H.C., Peacocke, M. Exp. Cell Res. (1995) [Pubmed]
  21. Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients. Chan, M.W., Chan, L.W., Tang, N.L., Tong, J.H., Lo, K.W., Lee, T.L., Cheung, H.Y., Wong, W.S., Chan, P.S., Lai, F.M., To, K.F. Clin. Cancer Res. (2002) [Pubmed]
  22. The ligand binding domain of the human retinoic acid receptor gamma is predominantly alpha-helical with a Trp residue in the ligand binding site. Lupisella, J.A., Driscoll, J.E., Metzler, W.J., Reczek, P.R. J. Biol. Chem. (1995) [Pubmed]
  23. A retinoic acid receptor-specific element controls the retinoic acid receptor-beta promoter. Hoffmann, B., Lehmann, J.M., Zhang, X.K., Hermann, T., Husmann, M., Graupner, G., Pfahl, M. Mol. Endocrinol. (1990) [Pubmed]
  24. RARbeta ligand-binding domain bound to an SRC-1 co-activator peptide: purification, crystallization and preliminary X-ray diffraction analysis. Kammerer, S., Germain, P., Flaig, R., Peluso-Iltis, C., Mitschler, A., Rochel, N., Gronemeyer, H., Moras, D. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  25. Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression. Farboud, B., Hauksdottir, H., Wu, Y., Privalsky, M.L. Mol. Cell. Biol. (2003) [Pubmed]
  26. Identification and characterization of nuclear retinoic acid-binding activity in human myeloblastic leukemia HL-60 cells. Nervi, C., Grippo, J.F., Sherman, M.I., George, M.D., Jetten, A.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  27. Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells. Lin, B., Chen, G.Q., Xiao, D., Kolluri, S.K., Cao, X., Su, H., Zhang, X.K. Mol. Cell. Biol. (2000) [Pubmed]
  28. Btg2 enhances retinoic acid-induced differentiation by modulating histone H4 methylation and acetylation. Passeri, D., Marcucci, A., Rizzo, G., Billi, M., Panigada, M., Leonardi, L., Tirone, F., Grignani, F. Mol. Cell. Biol. (2006) [Pubmed]
  29. Establishment and characterization of cell lines from three human thyroid carcinomas: Responses to all-trans-retinoic acid and mutations in the BRAF gene. Koh, C.S., Ku, J.L., Park, S.Y., Kim, K.H., Choi, J.S., Kim, I.J., Park, J.H., Oh, S.K., Chung, J.K., Lee, J.H., Kim, W.H., Kim, C.W., Cho, B.Y., Park, J.G. Mol. Cell. Endocrinol. (2007) [Pubmed]
  30. Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells. Li, M., Song, S., Lippman, S.M., Zhang, X.K., Liu, X., Lotan, R., Xu, X.C. Oncogene (2002) [Pubmed]
  31. Overexpression of retinoic acid receptor beta induces growth arrest and apoptosis in oral cancer cell lines. Hayashi, K., Yokozaki, H., Naka, K., Yasui, W., Lotan, R., Tahara, E. Jpn. J. Cancer Res. (2001) [Pubmed]
  32. Retinoic acid receptor beta induces terminal differentiation of squamous cell carcinoma lines in the absence of cyclin-dependent kinase inhibitor expression. Crowe, D.L. Cancer Res. (1998) [Pubmed]
  33. All-trans-retinoic acid treatment inhibits the growth of retinoic acid receptor beta messenger ribonucleic acid expressing thyroid cancer cell lines but does not reinduce the expression of thyroid-specific genes. Elisei, R., Vivaldi, A., Agate, L., Ciampi, R., Molinaro, E., Piampiani, P., Romei, C., Faviana, P., Basolo, F., Miccoli, P., Capodanno, A., Collecchi, P., Pacini, F., Pinchera, A. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  34. Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes. Kok, K., Naylor, S.L., Buys, C.H. Adv. Cancer Res. (1997) [Pubmed]
  35. Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARbeta-RXRalpha heterodimers and Sp1 and Sp3 to their binding sequences in the TM promoter. Ishii, H., Tezuka, T., Ishikawa, H., Takada, K., Oida, K., Horie, S. Blood (2003) [Pubmed]
  36. Retinoic acid-induced expression of CD38 antigen in myeloid cells is mediated through retinoic acid receptor-alpha. Drach, J., McQueen, T., Engel, H., Andreeff, M., Robertson, K.A., Collins, S.J., Malavasi, F., Mehta, K. Cancer Res. (1994) [Pubmed]
  37. Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Fang, M.Z., Wang, Y., Ai, N., Hou, Z., Sun, Y., Lu, H., Welsh, W., Yang, C.S. Cancer Res. (2003) [Pubmed]
  38. Cross-resistance to the synthetic retinoid CD437 in a paclitaxel-resistant human ovarian carcinoma cell line is independent of the overexpression of retinoic acid receptor-gamma. Kumar, A., Soprano, D.R., Parekh, H.K. Cancer Res. (2001) [Pubmed]
  39. Retinoic acid receptor and retinoid X receptor alterations in lung cancer precursor lesions. Martinet, N., Alla, F., Farré, G., Labib, T., Drouot, H., Vidili, R., Picard, E., Gaube, M.P., Le Faou, D., Siat, J., Borelly, J., Vermylen, P., Bazarbachi, T., Vignaud, J.M., Martinet, Y. Cancer Res. (2000) [Pubmed]
  40. Growth suppression of transformed human bronchial epithelial cells by all-trans-retinoic acid occurs through specific retinoid receptors. Ahn, M.J., Langenfeld, J., Moasser, M.M., Rusch, V., Dmitrovsky, E. Oncogene (1995) [Pubmed]
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