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Chemical Compound Review

TACA     (E)-4-aminobut-2-enoic acid

Synonyms: CHEMBL33086, AC1NSJS2, BSPBio_002528, T1694_SIGMA, CCG-39246, ...
 
 
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Psychiatry related information on cis-4-Aminocrotonic acid

 

High impact information on cis-4-Aminocrotonic acid

 

Biological context of cis-4-Aminocrotonic acid

  • From several potent inhibitors showing IC50 values at mGAT3 and mGAT4 in the low microM range cis-4-aminocrotonic acid and (RS)-2,3-diaminopropionic acid turned out to be most subtype selective for these transporters [7].
 

Associations of cis-4-Aminocrotonic acid with other chemical compounds

 

Gene context of cis-4-Aminocrotonic acid

References

  1. Spontaneous REM sleep is modulated by the activation of the pedunculopontine tegmental GABAB receptors in the freely moving rat. Ulloor, J., Mavanji, V., Saha, S., Siwek, D.F., Datta, S. J. Neurophysiol. (2004) [Pubmed]
  2. Molecular and physiological evidence for functional gamma-aminobutyric acid (GABA)-C receptors in growth hormone-secreting cells. Gamel-Didelon, K., Kunz, L., Fohr, K.J., Gratzl, M., Mayerhofer, A. J. Biol. Chem. (2003) [Pubmed]
  3. Correlation of the apparent affinities and efficacies of gamma-aminobutyric acid(C) receptor agonists. Chang, Y., Covey, D.F., Weiss, D.S. Mol. Pharmacol. (2000) [Pubmed]
  4. Gamma-aminobutyric acid (GABA)-C receptor stimulation increases prolactin (PRL) secretion in cultured rat anterior pituitary cells. Nakayama, Y., Hattori, N., Otani, H., Inagaki, C. Biochem. Pharmacol. (2006) [Pubmed]
  5. Drosophila melanogaster GRD and LCCH3 subunits form heteromultimeric GABA-gated cation channels. Gisselmann, G., Plonka, J., Pusch, H., Hatt, H. Br. J. Pharmacol. (2004) [Pubmed]
  6. Role of GABAA and GABAC receptors in the biphasic GABA responses in neurons of the rat major pelvic ganglia. Akasu, T., Munakata, Y., Tsurusaki, M., Hasuo, H. J. Neurophysiol. (1999) [Pubmed]
  7. Novel parent structures for inhibitors of the murine GABA transporters mGAT3 and mGAT4. Kragler, A., Höfner, G., Wanner, K.T. Eur. J. Pharmacol. (2005) [Pubmed]
  8. GABA-Induced Cl- current in cultured embryonic human dorsal root ganglion neurons. Valeyev, A.Y., Hackman, J.C., Holohean, A.M., Wood, P.M., Katz, J.L., Davidoff, R.A. J. Neurophysiol. (1999) [Pubmed]
  9. Bicuculline-resistant, Cl- dependent GABA response in the rat spinal dorsal horn. Park, J.S., Higashi, H., Nagata, K., Yoshimura, M. Neurosci. Res. (1999) [Pubmed]
  10. GABA(C) receptors in neuroendocrine gut cells: a new GABA-binding site in the gut. Jansen, A., Hoepfner, M., Herzig, K.H., Riecken, E.O., Scherübl, H. Pflugers Arch. (2000) [Pubmed]
 
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