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Chemical Compound Review

TACA     (E)-4-aminobut-2-enoic acid

Synonyms: CHEMBL33086, AC1NSJS2, BSPBio_002528, T1694_SIGMA, CCG-39246, ...
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Psychiatry related information on cis-4-Aminocrotonic acid


High impact information on cis-4-Aminocrotonic acid


Biological context of cis-4-Aminocrotonic acid

  • From several potent inhibitors showing IC50 values at mGAT3 and mGAT4 in the low microM range cis-4-aminocrotonic acid and (RS)-2,3-diaminopropionic acid turned out to be most subtype selective for these transporters [7].

Associations of cis-4-Aminocrotonic acid with other chemical compounds


Gene context of cis-4-Aminocrotonic acid


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  7. Novel parent structures for inhibitors of the murine GABA transporters mGAT3 and mGAT4. Kragler, A., Höfner, G., Wanner, K.T. Eur. J. Pharmacol. (2005) [Pubmed]
  8. GABA-Induced Cl- current in cultured embryonic human dorsal root ganglion neurons. Valeyev, A.Y., Hackman, J.C., Holohean, A.M., Wood, P.M., Katz, J.L., Davidoff, R.A. J. Neurophysiol. (1999) [Pubmed]
  9. Bicuculline-resistant, Cl- dependent GABA response in the rat spinal dorsal horn. Park, J.S., Higashi, H., Nagata, K., Yoshimura, M. Neurosci. Res. (1999) [Pubmed]
  10. GABA(C) receptors in neuroendocrine gut cells: a new GABA-binding site in the gut. Jansen, A., Hoepfner, M., Herzig, K.H., Riecken, E.O., Scherübl, H. Pflugers Arch. (2000) [Pubmed]
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