Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AC1NSMWS (6Z,9Z,12Z,15Z)-octadeca- 6,9,12,15...

Synonyms: Moroctic acid, CHEMBL484430, CHEBI:32389, HMDB06547, LMFA01030357, ...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Stearidonic acid

Comparison of stearidonic acid and alpha-linolenic acid on PGE2 production and COX-2 protein levels in MDA-MB-231 breast cancer cell cultures [1].

High impact information on Stearidonic acid

Substrate specificity analysis revealed that this fungal enzyme acted also on stearidonic acid (18:4n-3) [2].
Functional characterisation of these desaturases in yeast revealed that the recombinant Primula enzymes displayed substrate preferences, resulting in the predominant synthesis of either gamma-linolenic acid (n-6) or stearidonic acid (n-3) [3].
The objective of this study was to investigate the effect of dietary Echium oil, a plant oil containing the 18-carbon (n-3) PUFA stearidonic acid, on tissue fatty acid content and serum triacylglycerol concentrations in hypertriglyceridemic humans [4].
The effects of dietary stearidonic acid (18:4n-3) on inflammatory mediator release in whole blood and splenocytes was investigated in Balb/c mice, and the effects were compared with those of two other n-3 PUFA: alpha-linolenic acid (18:3n-3) and EPA (20:5n-3) [5].
Stearidonic acid, an inhibitor of the 5-lipoxygenase pathway. A comparison with timnodonic and dihomogammalinolenic acid [6].

Anatomical context of Stearidonic acid

To illuminate the underlying processes, we studied the conversions of stearidonic acid, 18:4(n-3), and its elongation product, 20:4(n-3), in TF cells and also in a cell line, AS, derived from Atlantic salmon (Salmo salar), by adding unlabelled (25 microM), U-14C (1 microM) or deuterated (d5; 25 microM) fatty acids [7].

Associations of Stearidonic acid with other chemical compounds

The bioactivity of stearidonic acid (SDA, 18:4n-3) and alpha-linolenic acid (LNA, 18:3n-3) on cyclooxygenase-2 (COX-2) enzyme expression and prostaglandin E2 (PGE2) production has not been evaluated [1].
Low C18 to C20 fatty acid elongase activity and limited conversion of stearidonic acid, 18:4(n-3), to eicosapentaenoic acid, 20:5(n-3), in a cell line from the turbot, Scophthalmus maximus [7].

Analytical, diagnostic and therapeutic context of Stearidonic acid

Purification of stearidonic acid (18:4(n-3)) and hexadecatetraenoic acid (16:4(n-3)) from algal fatty acid with lipase and medium pressure liquid chromatography [8].

References

Comparison of stearidonic acid and alpha-linolenic acid on PGE2 production and COX-2 protein levels in MDA-MB-231 breast cancer cell cultures. Horia, E., Watkins, B.A. J. Nutr. Biochem. (2005) [Pubmed]
Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids. Parker-Barnes, J.M., Das, T., Bobik, E., Leonard, A.E., Thurmond, J.M., Chaung, L.T., Huang, Y.S., Mukerji, P. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
Identification of Primula "front-end" desaturases with distinct n-6 or n-3 substrate preferences. Sayanova, O., Haslam, R., Venegas-Caler??n, M., Napier, J.A. Planta (2006) [Pubmed]
Dietary echium oil increases plasma and neutrophil long-chain (n-3) fatty acids and lowers serum triacylglycerols in hypertriglyceridemic humans. Surette, M.E., Edens, M., Chilton, F.H., Tramposch, K.M. J. Nutr. (2004) [Pubmed]
Comparison of the effects of dietary alpha-linolenic, stearidonic, and eicosapentaenoic acids on production of inflammatory mediators in mice. Ishihara, K., Komatsu, W., Saito, H., Shinohara, K. Lipids (2002) [Pubmed]
Stearidonic acid, an inhibitor of the 5-lipoxygenase pathway. A comparison with timnodonic and dihomogammalinolenic acid. Guichardant, M., Traitler, H., Spielmann, D., Sprecher, H., Finot, P.A. Lipids (1993) [Pubmed]
Low C18 to C20 fatty acid elongase activity and limited conversion of stearidonic acid, 18:4(n-3), to eicosapentaenoic acid, 20:5(n-3), in a cell line from the turbot, Scophthalmus maximus. Ghioni, C., Tocher, D.R., Bell, M.V., Dick, J.R., Sargent, J.R. Biochim. Biophys. Acta (1999) [Pubmed]
Purification of stearidonic acid (18:4(n-3)) and hexadecatetraenoic acid (16:4(n-3)) from algal fatty acid with lipase and medium pressure liquid chromatography. Ishihara, K., Murata, M., Kaneniwa, M., Saito, H., Komatsu, W., Shinohara, K. Biosci. Biotechnol. Biochem. (2000) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.