Disease relevance of Flatfishes

• Possible role of LTB4 in the antiviral activity of turbot (Scophthalmus maximus) leukocyte-derived supernatants against viral hemorrhagic septicemia virus (VHSV) [1].
• Intradermal injection of the phosphorylcholine-containing fraction caused an immediate erythema reaction in all mature turbot tested [2].
• Immune response to a recombinant capsid protein of striped jack nervous necrosis virus (SJNNV) in turbot Scophthalmus maximus and Atlantic halibut Hippoglossus hippoglossus, and evaluation of a vaccine against SJNNV [3].
• The field results show that delivering an oral boost after the primary vaccination by injection did not enhance protection of turbot against furunculosis and that water-based (autogenous vaccine) and oil adjuvanted (Alpha Ject 1200) vaccines administered by injection conferred similar levels of protection (RPS > 80%) in turbot [4].
• Poly I:C significantly stimulated turbot IRF-1 expression in muscle, spleen and kidney 24 h post-treatment, while viral haemorrhagic septicemia virus (VHSV) induced a differential expression of this factor in kidney 8 h after infection [5].

Psychiatry related information on Flatfishes

• Daily locomotor activity and melatonin rhythms in Senegal sole (Solea senegalensis) [6].

High impact information on Flatfishes

• The corresponding values for sulfamethoxazole were 0.3 to 4 micrograms/g (sea bass), 1 to 42 micrograms/g (turbot), and 4 to 35 micrograms/g (white shrimp) [7].
• Our results suggest that the progressive expression of calretinin in the turbot retina appears associated with some degree of neuronal differentiation [8].
• The antibacterial activities of components of a glycoprotein nature present in the turbot skin mucus are probably responsible in part for the resistance in noninjured fish to infection [9].
• Strains of V. anguillarum could be divided into groups, with the main group containing serotype O1 and O2 strains isolated from Atlantic salmon, rainbow trout, turbot, cod, and saithe [10].
• As a positive control for the sediment exposure experiment, a subsample of the turbot was exposed to cadmium chloride-spiked seawater [11].

Chemical compound and disease context of Flatfishes

• A study of the susceptibility of Atlantic halibut, Hippoglossus hippoglossus (L.), to viral haemorrhagic septicaemia virus isolated from turbot, Scophthalmus maximus (L.) [12].
• Acute toxicity of fluorescein to turbot (Scophthalmus maximus) [13].
• Toxicity and elevation of 7-ethoxyresorufin O-deethylase activity in turbot (Scophthalmus maximus L.) sarvae exposed to contaminated sea surface microlayer [14].

Biological context of Flatfishes

• Genetic population structure of turbot (Scophthalmus maximus L.) in the Northeast Atlantic was investigated using eight highly variable microsatellite loci [15].
• Using biochemical genetic methods, we have distinguished 2 sibling species in the complex Bothrimonus nylandicus (Schneider, 1902), which infest 2 congeneric species of sole (Solea lascaris and Solea impar) on European coasts (Atlantic and Mediterranean) [16].
• The amino acid sequences of fIRs and fIGF-IRs showed more than 90% sequence identity with turbot IR and IGF-IR respectively [17].
• A surface-spreading synaptonemal complex (SC) technique was used to analyse spermatocytes and oocytes of triploid turbot (Scophthalmus maximus) in order to visualise the process of chromosome synapsis [18].
• 3. No significant differences were seen between male and female turbot FMO with respect to DMA N-oxidase activity, levels of immunoreactive protein (with anti-FMO 1 or anti-FMO 2) and gene expression (hybridizing mRNA) [19].

Anatomical context of Flatfishes

• Since previous work demonstrated that leukotriene B4 (LTB4) was present in turbot blood leukocyte-derived supernatants, we assessed the effect of the VHSV in vitro infection on turbot leukocyte LTB4 production by high performance liquid chromatography (HPLC) [1].
• Finally, the histolytic activity of the ciliate in turbot fibroblast monolayers was strongly reduced in the presence of E-64, confirming the importance of secreted cysteine proteinases in the biology of Philasterides dicentrarchi [20].
• The soluble organic matrix (OM) of various biominerals (red coral skeleton, oyster shell, sea urchin test, turbot otolith, chicken eggshell) was extracted after demineralization with acetic acid [21].
• NADPH diaphorase activity is asymmetrically distributed in the optic tectum during the period of eye migration in turbots [22].
• Only very low amounts of LTC were produced by the turbot astrocytes, with only substance P showing a minor stimulatory effect [23].

Associations of Flatfishes with chemical compounds

• Isolation of a phosphorylcholine-containing component from the turbot tapeworm, Bothriocephalus scorpii (Müller), and its reaction with C-reactive protein [2].
• In this work, polyclonal antibodies directed against vitelline envelope proteins from rainbow trout, brown trout and turbot were used to show that oestradiol-17 beta induces the major vitelline envelope proteins in juveniles, both males and females, from different species [24].
• The effect of different cytokines and bacterial lipopolysaccharide (LPS) on turbot (Scophthalmus maximus) macrophage nitric oxide (NO) production has been studied [25].
• Selection and identification of autochthonous potential probiotic bacteria from turbot larvae (Scophthalmus maximus) rearing units [26].
• Dietary n-3 long-chain polyunsaturated fatty acid deprivation, tissue lipid composition, ex vivo prostaglandin production, and stress tolerance in juvenile Dover sole (Solea solea L.) [27].

Gene context of Flatfishes

• When compared with their mammalian homologues, fIGF-IR-1 and fIGF-IR-2 proteins contained large insertions at their C-termini, as was observed in the corresponding region of turbot IGF-IR [17].
• All of these characteristics led to the identification of turbot and sea bream IRFs as IRF-1 [5].
• Pituitary growth hormone secretion in the turbot, a phylogenetically recent teleost, is regulated by a species-specific pattern of neuropeptides [28].
• Ontogeny of IGF-1 and the classical islet hormones in the turbot, Scophthalmus maximus [29].
• To assess the significance of MSH to biological activities, we determined the structure and evaluated the expression of POMC mRNA in barfin flounder (bf), Verasper moseri, a member of a group of teleosts, Pleuronectiformes [30].

Analytical, diagnostic and therapeutic context of Flatfishes

• The expression of the calcium-binding protein calretinin was analysed by immunohistochemistry techniques in the retina of turbot (Psetta maxima) from embryonic to juvenile stages [8].
• A fraction isolated by electrofocusing (pI 4.2) from a saline extract of the turbot parasite, Bothriocephalus scorpii, contained choline and precipitated with a teleost C-reactive protein (CRP) and a phosphorylcholine-binding Balb/c mouse myeloma protein, TEPC-15 [2].
• Molecular cloning and developmental expression patterns of thyroid hormone receptors and T3 target genes in the turbot (Scophtalmus maximus) during post-embryonic development [31].
• A non-isotopic in situ hybridization (ISH) method was developed for detection of Tetramicra brevifilum, a commercially important parasite in farmed turbot Scophthalmus maximus [32].
• Restriction site analysis of polymerase chain reaction (PCR) products from a conserved region of the cytochrome b gene has been used for the specific identification of sole (Solea solea), European plaice (Pleuronectes platessa), flounder (Platichthys flesus), and Greenland halibut (Reinhardtius hippoglossoides) [33].

References