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Chemical Compound Review

E5641_SIGMA     (5E,8E)-10-[3-[(E)-oct-2- enyl]oxiran-2...

Synonyms: HMDB04673, LS-59241, AC1NS3ZE, 11,12-Eet, 81276-02-0, ...
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Disease relevance of 11,12-epoxyeicosatrienoic acid


High impact information on 11,12-epoxyeicosatrienoic acid


Biological context of 11,12-epoxyeicosatrienoic acid


Anatomical context of 11,12-epoxyeicosatrienoic acid


Associations of 11,12-epoxyeicosatrienoic acid with other chemical compounds


Gene context of 11,12-epoxyeicosatrienoic acid


Analytical, diagnostic and therapeutic context of 11,12-epoxyeicosatrienoic acid


  1. Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes. Wu, S., Chen, W., Murphy, E., Gabel, S., Tomer, K.B., Foley, J., Steenbergen, C., Falck, J.R., Moomaw, C.R., Zeldin, D.C. J. Biol. Chem. (1997) [Pubmed]
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  3. 11,12-Epoxyeicosatrienoic acid stimulates endogenous mono-ADP-ribosylation in bovine coronary arterial smooth muscle. Li, P.L., Chen, C.L., Bortell, R., Campbell, W.B. Circ. Res. (1999) [Pubmed]
  4. 11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1. Potente, M., Fisslthaler, B., Busse, R., Fleming, I. J. Biol. Chem. (2003) [Pubmed]
  5. Nifedipine increases cytochrome P4502C expression and endothelium-derived hyperpolarizing factor-mediated responses in coronary arteries. Fisslthaler, B., Hinsch, N., Chataigneau, T., Popp, R., Kiss, L., Busse, R., Fleming, I. Hypertension (2000) [Pubmed]
  6. Afferent arteriolar vasodilation to the sulfonimide analog of 11, 12-epoxyeicosatrienoic acid involves protein kinase A. Imig, J.D., Inscho, E.W., Deichmann, P.C., Reddy, K.M., Falck, J.R. Hypertension (1999) [Pubmed]
  7. Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid. Imig, J.D., Zhao, X., Falck, J.R., Wei, S., Capdevila, J.H. J. Hypertens. (2001) [Pubmed]
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  11. Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase. Sacerdoti, D., Bolognesi, M., Di Pascoli, M., Gatta, A., McGiff, J.C., Schwartzman, M.L., Abraham, N.G. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  12. Potentiation of Ca2+ signaling in endothelial cells by 11,12-epoxyeicosatrienoic acid. Mombouli, J.V., Holzmann, S., Kostner, G.M., Graier, W.F. J. Cardiovasc. Pharmacol. (1999) [Pubmed]
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  15. 11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression. Falck, J.R., Reddy, L.M., Reddy, Y.K., Bondlela, M., Krishna, U.M., Ji, Y., Sun, J., Liao, J.K. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
  16. 11,12-Epoxyeicosatrienoic acid stimulates heme-oxygenase-1 in endothelial cells. Sacerdoti, D., Colombrita, C., Di Pascoli, M., Schwartzman, M.L., Bolognesi, M., Falck, J.R., Gatta, A., Abraham, N.G. Prostaglandins Other Lipid Mediat. (2007) [Pubmed]
  17. Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid. Ye, D., Zhou, W., Lee, H.C. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  18. Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites. Carroll, M.A., Garcia, M.P., Falck, J.R., McGiff, J.C. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  19. Effect of 11,12-epoxyeicosatrienoic acid as an additive to St. Thomas' cardioplegia and University of Wisconsin solutions on endothelium-derived hyperpolarizing factor-mediated function in coronary microarteries: influence of temperature and time. Yang, Q., Zhang, R.Z., Yim, A.P., He, G.W. Ann. Thorac. Surg. (2003) [Pubmed]
  20. Direct modulation of tracheal Cl--channel activity by 5,6- and 11,12-EET. Salvail, D., Dumoulin, M., Rousseau, E. Am. J. Physiol. (1998) [Pubmed]
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