Disease relevance of bleomycin

• FLM possessed an antiproliferative potency similar to liblomycin in BLM-sensitive human A-253 squamous carcinoma cells but was less potent than BLM A2 or TLM S10b [1].
• However, fibrosis in these mice was equal to that found after BL alone [2].
• Since the X ray dose enhancement factor for NMF alone was about 1.3, the increased toxicity seen is probably additive in nature for the NMF + 5-FU + x experiments, but more than additive for the NMF + Bleo + x experiments [3].
• Morbidity and mortality appeared to be related to severe lung changes similar to the hyperoxic potentiation of BLM lung disease [4].
• In the present investigation, a poly(DL-co-glycolide) (PLGA)-based, microspheric depot system for bleomycin (BLM) has been formulated, and the same has been evaluated in-vivo in C57BL/6J mice bearing transplantable melanoma B16F1 murine solid tumour [5].

High impact information on bleomycin

• FLM like BLM cleaved pGEM-3Z plasmid DNA in vitro in a concentration-dependent manner [1].
• Our results indicate selective induction of the GPX1 gene by BLM and different redox responses to BLM between WI38 and VA13 cells [6].
• In this study, the extent of cytotoxicity, levels of ROS, and activities of antioxidant enzymes were compared between normal WI38 cells and SV40-transformed WI38 (VA13) cells following BLM treatment [6].
• Although BLM caused greater growth inhibition and apoptosis in VA13 cells, it increased ROS levels at an earlier time point in WI38 cells [6].
• We hypothesized that BLM could cause a different status of oxidative stress in normal versus tumor cells due to possible altered redox status and gene expression in cells following transformation [6].

Chemical compound and disease context of bleomycin

• Mice received 2 mg carbon by intratracheal instillation into lungs already showing acute injury, 3 days after bleomycin (BL), or into lungs with fibrosis, 4 weeks after BL [2].

Anatomical context of bleomycin

• At 3 days after BL, injury to the type I alveolar epithelium resulted in high protein levels in lavage fluid [2].

Associations of bleomycin with other chemical compounds

• Rats were given daily subcutaneous injections of tallysomycin S10b (TLM) or bleomycin (BLM) for 6 days (1.25 or 2.50 mg/day) [4].

Gene context of bleomycin

• With both GSH and Fe and compared with BSA, SOD enhanced the effect of HQ, BQ and BLM, ameliorated the effect of H2O2, and did not affect the others [7].

References