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Chemical Compound Review

Aldrox     aluminum tetrahydrate

Synonyms: Pepsamar, Pepsitox, Algeldrato, Algeldratum, Hydrargillit, ...
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Disease relevance of Aldrox

  • The results provide reassurance that Aludrox does not promote colon cancer and tend to contradict the bile salt theory of colon carcinogenesis [1].
  • Double-blind comparison of an oxethazaine-antacid combination (Oxaine M) against the antacid alone (Aludrox) in the treatment of duodenal ulcer pain [2].
  • Six healthy male volunteers aged 20 to 28 years with a mean body weight of 68 +/- 8 kg received 40 mg muzolimine after a standardized breakfast without and with 1760 mg aluminium hydroxide (Aludrox) administered 10 min before breakfast [3].
  • The effect of Mucaine and Aludrox on basal and food stimulated immunoreactive gastrin has been assessed in normal control subjects and patients with duodenal or gastric ulcer [4].

High impact information on Aldrox


Chemical compound and disease context of Aldrox

  • After 1 year's observation, there were no significant differences between the groups of DMH-injected rats given drinking water with or without Aludrox in respect of survival, necropsy incidence of primary or metastatic colon cancer, or in the total number of colon tumours per group [1].


  1. Experimental evidence against the bile salt theory of colon carcinogenesis. Cruse, J.P., Lewin, M.R., Ferulano, G.P., Clark, C.G. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes. (1981) [Pubmed]
  2. Double-blind comparison of an oxethazaine-antacid combination (Oxaine M) against the antacid alone (Aludrox) in the treatment of duodenal ulcer pain. Pontes, J.F., Richards, D.J., Sartoretto, J.N. Current therapeutic research, clinical and experimental. (1975) [Pubmed]
  3. Pharmacokinetics of muzolimine after oral administration with and without aluminium hydroxide in healthy volunteers. Ritter, W., Hanisch, M., Lücker, P.W., Venitz, F., Hey, B., Baykal, N. Zeitschrift für Kardiologie. (1985) [Pubmed]
  4. The effect of mucaine on gastrin release in man. Taggart, G.J., Hansky, J. Australian and New Zealand journal of medicine. (1978) [Pubmed]
  5. Decreased bioavailability of prednisone due to antacids in patients with chronic active liver disease and in healthy volunteers. Uribe, M., Casian, C., Rojas, S., Sierra, J.G., Go, V.L. Gastroenterology (1981) [Pubmed]
  6. Effect of food on antacid neutralizing capacity in man. Halter, F., Huber, R., Häcki, W.H., Varga, L., Bachmann, C. Eur. J. Clin. Invest. (1982) [Pubmed]
  7. Intestinal absorption of aluminium from antacids: a comparison between hydrotalcite and algeldrate. van der Voet, G.B., de Wolff, F.A. J. Toxicol. Clin. Toxicol. (1986) [Pubmed]
  8. A comparison between Gastrils and Aludrox in the treatment of gastric hyperacidity in general practice. Jaffé, G., Grimshaw, J.J. J. Int. Med. Res. (1982) [Pubmed]
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