Disease relevance of Aldrox

• The results provide reassurance that Aludrox does not promote colon cancer and tend to contradict the bile salt theory of colon carcinogenesis [1].
• Double-blind comparison of an oxethazaine-antacid combination (Oxaine M) against the antacid alone (Aludrox) in the treatment of duodenal ulcer pain [2].
• Six healthy male volunteers aged 20 to 28 years with a mean body weight of 68 +/- 8 kg received 40 mg muzolimine after a standardized breakfast without and with 1760 mg aluminium hydroxide (Aludrox) administered 10 min before breakfast [3].
• The effect of Mucaine and Aludrox on basal and food stimulated immunoreactive gastrin has been assessed in normal control subjects and patients with duodenal or gastric ulcer [4].

High impact information on Aldrox

• After administering two 5-mg tablets of prednisone with 60 ml of water, 60 ml of Melox (AlOH 3.75 g/100 ml + MgOH 4.0 g/100 ml), or 60 ml of Aldrox (AlOH 8.0 g/100 ml + MgOH 1.95 g/100 ml), we measured prednisolone by radioimmunoassay [5].
• The relative bioavailability of prednisone after prednisone-antacid treatments compared to that after prednisone-water treatment was 74% +/- 13% (p less than 0.05) with Melox and 57% +/- 15% (p less than 0.01) with Aldrox in healthy volunteers [5].
• In-vitro studies demonstrated that interaction with oxo reduced the neutralizing capacity of the two antacids at pH 3.5 from 3.9 mol/l to 1.7 mol/l (Alucol) and 2.5 mol/l (Camalox) [6].
• The intestinal absorption of aluminium (Al) from the antacid hydrotalcite (Ultacit) was compared with that from algeldrate (Algeldratum des-acidans) in 8 healthy human subjects in a cross-over study [7].
• A comparison between Gastrils and Aludrox in the treatment of gastric hyperacidity in general practice [8].

Chemical compound and disease context of Aldrox

• After 1 year's observation, there were no significant differences between the groups of DMH-injected rats given drinking water with or without Aludrox in respect of survival, necropsy incidence of primary or metastatic colon cancer, or in the total number of colon tumours per group [1].

References