Disease relevance of FH 099

• TV fistula oxethazaine did not diminish the magnitude of postprandial absorption [1].
• A double-blind study was carried out in 40 patients with typical ulcer pain and suffering from gastric or duodenal ulcer to compare the pain-relieving efficacy of oxethazaine/magnesium and aluminium hydroxide mixture with that of the antacid combination alone [2].
• Is mucaine an appropriate medication for the relief of heartburn during pregnancy [3]?
• Ca2+ enhancement of hemolysis induced by the topical anesthetic oxethazaine in vitro [4].
• Currently, oxethazaine is used in an antacid preparation for the topical relief of pain in conditions such as hiatus hernia, where the local pH is very low [5].

High impact information on FH 099

• Biphasic effects of oxethazaine, a topical anesthetic, on the intracellular Ca(2+) concentration of PC12 cells [6].
• We previously reported that, in isolated perfused rat livers in a constant flow system, oxethazaine (OXZ) rapidly increased portal pressure (PP) accompanied by inhibition of oxygen uptake and the subsequent metabolic effects [7].
• Alteration of hepatic microcirculation by oxethazaine and some vasoconstrictors in the perfused rat liver [7].
• The jejunal meal significantly increased TV fistula absorption, whereas oxethazaine significantly reduced basal absorption when administered via the TV fistula and postprandial absorption when administered via the jejunostomy (p less than 0.05) [1].
• Using intraluminal topical anesthesia with oxethazaine, this study assessed the role of intestinal neural pathways in basal and postprandial jejunal water and electrolyte absorption [1].

Chemical compound and disease context of FH 099

• Oxethazaine combined with aluminum and magnesium hydroxide (Oxaine M) in duodenal ulcer pain: a double-blind clinical pharmacology study [8].

Biological context of FH 099

• The effect of exogenous cholecystokinin (CCK) on the gastric emptying of liquid and solid diets, as well as the action of oxethazaine, a topical anesthetic, on the satiety effect of endogenous CCK, were investigated in adult rats [9].
• Effect of oxethazaine HCl on control of food and water intake in the rat [10].
• The addition of the oxethazaine HCl to the diet (0.5 gm/100 gm diet) markedly reduced food intake [10].

Anatomical context of FH 099

• From kinetic analyses, it seems that oxethazaine acted as noncompetitive inhibitor of hydrogen ion on the chemoreceptors of the secretin-releasing cells in the duodenal mucosa [11].
• Mechanisms involved in the contraction of intrahepatic portal vein branches by clomipramine and oxethazaine in isolated perfused rat livers [12].
• Oxethazaine (OXZ), a potent topical anesthetic, was found to induce red blood cell (RBC) lysis in vitro, depending upon concentrations of OXZ, RBC and Ca2+ [4].
• If a mixture of aluminium hydroxide, magnesium carbonate and oxethazaine was added to the aspirate, development of lung fibrosis was prevented, but severe granulomatous reaction with foreign body giant cells within both lungs evolved [13].
• 281 patients, divided into two groups, were given single 30 ml dose of five different conventional oral antacids (sodium citrate, 0.3 M Maalox, Gelusil, Alludrox and Mucaine), separately and in combination with Cimetidine to study their effect on decreasing the acidity of stomach contents [14].

Associations of FH 099 with other chemical compounds

• The suppression of feeding produced by L-phenylalanine, which is known to release endogenous CCK, was abolished when the rats were pretreated with oxethazaine [9].
• The effects of five doses of procaine (10(-8)M approximately 10(-4)M) and seven doses of oxethazaine (10(-8)M approximately 10(-5)M) on 14C-aminopyrine accumulation in isolated parietal cells of guinea pigs induced by 10(-4)M carbachol were studied [15].

Gene context of FH 099

• The effect of mucaine on gastrin release in man [16].
• However, oxethazaine, clomipramine, and endothelin-1 may activate this pathway differently [17].

Analytical, diagnostic and therapeutic context of FH 099

• Oral administration of the local anesthetic oxethazaine HCl was used to modify eating and drinking patterns in the rat [10].
• Since oxethazaine is active in an acidic environment, it was decided to use oxethazaine, in a pilot study of 20 patients requiring minor oral surgery procedures, at a concentration of 0.1% at pH 3, to assess its value in achieving dental local anaesthesia [5].

References