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Chemical Compound Review

Betalgil     2-[2-hydroxyethyl-[[methyl- (2-methyl-1...

Synonyms: Topicain, Milzine, Mucaine, Mucoxin, Muthesa, ...
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Disease relevance of FH 099


High impact information on FH 099

  • Biphasic effects of oxethazaine, a topical anesthetic, on the intracellular Ca(2+) concentration of PC12 cells [6].
  • We previously reported that, in isolated perfused rat livers in a constant flow system, oxethazaine (OXZ) rapidly increased portal pressure (PP) accompanied by inhibition of oxygen uptake and the subsequent metabolic effects [7].
  • Alteration of hepatic microcirculation by oxethazaine and some vasoconstrictors in the perfused rat liver [7].
  • The jejunal meal significantly increased TV fistula absorption, whereas oxethazaine significantly reduced basal absorption when administered via the TV fistula and postprandial absorption when administered via the jejunostomy (p less than 0.05) [1].
  • Using intraluminal topical anesthesia with oxethazaine, this study assessed the role of intestinal neural pathways in basal and postprandial jejunal water and electrolyte absorption [1].

Chemical compound and disease context of FH 099


Biological context of FH 099


Anatomical context of FH 099


Associations of FH 099 with other chemical compounds

  • The suppression of feeding produced by L-phenylalanine, which is known to release endogenous CCK, was abolished when the rats were pretreated with oxethazaine [9].
  • The effects of five doses of procaine (10(-8)M approximately 10(-4)M) and seven doses of oxethazaine (10(-8)M approximately 10(-5)M) on 14C-aminopyrine accumulation in isolated parietal cells of guinea pigs induced by 10(-4)M carbachol were studied [15].

Gene context of FH 099


Analytical, diagnostic and therapeutic context of FH 099


  1. Meal-induced jejunal absorption requires intact neural pathways. Anthone, G.J., Wang, B.H., Zinner, M.J., Orandle, M.S., Yeo, C.J. Am. J. Surg. (1992) [Pubmed]
  2. A double-blind controlled study to compare the efficacy of an antacid plus oxethazaine with that of an antacid alone in the treatment of pain due to gastric or duodenal ulceration. Zanni, A., Gherardi, S., Crowther, P.S., De Tomasi, F., Scott, C.N., Bertoli, R. Current medical research and opinion. (1986) [Pubmed]
  3. Is mucaine an appropriate medication for the relief of heartburn during pregnancy? Kovacs, G.T., Campbell, J., Francis, D., Hill, D., Adena, M.A. Asia-Oceania journal of obstetrics and gynaecology / AOFOG. (1990) [Pubmed]
  4. Ca2+ enhancement of hemolysis induced by the topical anesthetic oxethazaine in vitro. Yasuno, R., Oguma, T., Masuda, Y. Biol. Pharm. Bull. (1998) [Pubmed]
  5. A preliminary report using oxethazaine--a potential new dental local anaesthetic. Brennan, P.A., Langdon, J.D. The British journal of oral & maxillofacial surgery. (1990) [Pubmed]
  6. Biphasic effects of oxethazaine, a topical anesthetic, on the intracellular Ca(2+) concentration of PC12 cells. Masuda, Y., Oguma, T., Kimura, A. Biochem. Pharmacol. (2002) [Pubmed]
  7. Alteration of hepatic microcirculation by oxethazaine and some vasoconstrictors in the perfused rat liver. Masuda, Y., Ozaki, M., Oguma, T. Biochem. Pharmacol. (1997) [Pubmed]
  8. Oxethazaine combined with aluminum and magnesium hydroxide (Oxaine M) in duodenal ulcer pain: a double-blind clinical pharmacology study. Cordeiro, F.T., Sartoretto, J.N., Richards, D.J. Current therapeutic research, clinical and experimental. (1976) [Pubmed]
  9. Effects of cholecystokinin and caerulein on gastric emptying. Anika, M.S. Eur. J. Pharmacol. (1982) [Pubmed]
  10. Effect of oxethazaine HCl on control of food and water intake in the rat. Pober, Z., Calhoun, W.K. Pharmacol. Biochem. Behav. (1975) [Pubmed]
  11. Inhibitory mechanism of oxethazaine on release of endogenous secretin and pancreatic response in dogs. Yamazaki, Y. Dig. Dis. Sci. (1982) [Pubmed]
  12. Mechanisms involved in the contraction of intrahepatic portal vein branches by clomipramine and oxethazaine in isolated perfused rat livers. Masuda, Y., Edo, T. J. Pharmacol. Sci. (2005) [Pubmed]
  13. The gastric juice aspiration syndrome (Mendelson syndrome). Aspects of pathogenesis and treatment in the pig. Popper, H., Juettner, F., Pinter, J. Virchows Archiv. A, Pathological anatomy and histopathology. (1986) [Pubmed]
  14. Antacid regimen in reducing gastric fluid acidity--comparison of conventional oral antacids with cimetidine. Channa, A.B., Seraj, M.A., Istafan, M.Y., Khan, F.M. Middle East journal of anesthesiology. (1985) [Pubmed]
  15. Effect of procaine and oxethazaine on muscarinic receptors of parietal cells. Tani, N., Watanabe, Y., Suzuki, T., Muramatsu, S., Miyazawa, M., Kimura, N., Miwa, T. Tokai J. Exp. Clin. Med. (1997) [Pubmed]
  16. The effect of mucaine on gastrin release in man. Taggart, G.J., Hansky, J. Australian and New Zealand journal of medicine. (1978) [Pubmed]
  17. Intrahepatic flow disturbance: possibility of a hidden cause of drug toxicity. Masuda, Y. J. Pharmacol. Sci. (2006) [Pubmed]
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