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Cbr1  -  carbonyl reductase 1

Rattus norvegicus

Synonyms: 20-beta-hydroxysteroid dehydrogenase, Cbr, NADPH-dependent carbonyl reductase 1, Prostaglandin 9-ketoreductase, Prostaglandin-E(2) 9-reductase
 
 
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Disease relevance of Cbr1

 

High impact information on Cbr1

 

Biological context of Cbr1

  • Nevertheless, the temporal pattern of expression of carbonyl reductase after the induction of ovulation suggests that this enzyme activity is at least indirectly associated with the ovulatory process [3].
  • The recombinant enzyme exhibited the same substrate specificity and susceptibility to inhibitors as the enzyme isolated from rat testis, and also closely resembled human carbonyl reductase [7].
  • The sequence obtained demonstrated a high degree of homology with an internal amino acid sequence in human carbonyl reductase (EC 1.1.1.184) [8].
  • These observations indicate that tissue distribution of 20beta-HSD is similar to that of carbonyl reductase in the human and rat [9].
  • Since the severe cardiotoxicity of anthracyclines has been attributed to the intramyocardial formation of C-13 alcohol metabolites, the kinetics of cardiac metabolite formation and disposition as well as the effect of carbonyl reductase inhibitors are of specific interest [10].
 

Anatomical context of Cbr1

 

Associations of Cbr1 with chemical compounds

 

Other interactions of Cbr1

 

Analytical, diagnostic and therapeutic context of Cbr1

  • Northern blot analyses indicated a 14-fold increase in ovarian mRNA for carbonyl reductase, with expression reaching a peak at 8 h after hCG treatment and then declining to negligible levels during the next 16 h [3].
  • 1. In the male rat, hepatic microsomal carbonyl reductase (CR) activity decreased by testectomy (Tx) was restored to the control level by the treatment with testosterone propionate (TP), even though the enzyme activity decreased by hypophysectomy (Hx) was not increased by the treatment with TP [11].
  • Ovarian CR activity was measured by using two substrates that reflect the activity of the enzyme in rats, and the enzyme content was determined by western blot analysis [16].
  • Carbonyl reductase activity and content in the rat ovary were measured at various stages of the estrous cycle, and the enzyme protein in the ovary was localized by immunohistochemistry [5].
  • Both eCG and oFSH significantly increased the ovarian carbonyl reductase concentration 48 h after treatment compared with the saline-treated group, but the increase with eCG was approximately twice that with oFSH [17].

References

  1. Studies on three reductases which have polycyclic aromatic hydrocarbon quinones as substrates. Jarabak, J., Harvey, R.G. Arch. Biochem. Biophys. (1993) [Pubmed]
  2. The protective role of 11 beta-hydroxysteroid dehydrogenase/carbonyl reductase against tobacco-smoke related lung cancer. Maser, E. Adv. Exp. Med. Biol. (1999) [Pubmed]
  3. Characterization of ovarian carbonyl reductase gene expression during ovulation in the gonadotropin-primed immature Rat. Espey, L.L., Yoshioka, S., Russell, D., Ujioka, T., Vladu, B., Skelsey, M., Fujii, S., Okamura, H., Richards, J.S. Biol. Reprod. (2000) [Pubmed]
  4. Reductions of nitro and 9-Oxo groups of environmental nitrofluorenes by the rat mammary gland in vitro. Ritter, C.L., Decker, R.W., Malejka-Giganti, D. Chem. Res. Toxicol. (2000) [Pubmed]
  5. Changes in rat ovarian carbonyl reductase activity and content during the estrous cycle, and localization. Iwata, N., Inazu, N., Satoh, T. Biol. Reprod. (1990) [Pubmed]
  6. Changes and localization of ovarian carbonyl reductase during pseudopregnancy and pregnancy in rats. Iwata, N., Inazu, N., Satoh, T. Biol. Reprod. (1990) [Pubmed]
  7. Cloning and expression of carbonyl reductase from rat testis. Wermuth, B., Mäder-Heinemann, G., Ernst, E. Eur. J. Biochem. (1995) [Pubmed]
  8. A novel 34 kDa glutathione-binding protein in mature rat ovary. Toft, E., Söderström, M., Ahlberg, M.B., DePierre, J.W. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  9. Immunochemical distribution and immunohistochemical localization of 20beta-hydroxysteroid dehydrogenase in neonatal pig tissues. Kobayashi, K., Ohno, S., Shinoda, M., Toyoshima, S., Nakajin, S. J. Steroid Biochem. Mol. Biol. (1996) [Pubmed]
  10. Modeling the metabolism of idarubicin to idarubicinol in rat heart: effect of rutin and phenobarbital. Kang, W., Weiss, M. Drug Metab. Dispos. (2003) [Pubmed]
  11. Differential hormonal regulation of carbonyl reductase activities in liver and kidney microsomes of rat. Imamura, Y., Takada, H., Kamizono, R., Otagiri, M. Xenobiotica (2002) [Pubmed]
  12. Reduction and glucuronidation of naftazone by human and rat liver microsomes. Herber, R., Hercelin, B., Van Cantfort, J., De Graeve, J., Fournel-Gigleux, S., Taguchi, T., Magdalou, J. Drug Metab. Dispos. (1995) [Pubmed]
  13. Transamination in the metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in rats. Cui, D., Rankin, G.O., Harvison, P.J. Drug Metab. Dispos. (2005) [Pubmed]
  14. Strain- and sex-related differences of carbonyl reductase activities in kidney microsomes and cytosol of rats. Imamura, Y., Shimada, H. Journal of applied toxicology : JAT. (2004) [Pubmed]
  15. Properties of carbonyl reductase activity of sepiapterin reductase, an enzyme involved in the biosynthesis of tetrahydrobiopterin. Katoh, S., Sueoka, T. Prog. Clin. Biol. Res. (1989) [Pubmed]
  16. Activation by human chorionic gonadotropin of ovarian carbonyl reductase in mature rats exposed in vivo to estrogens. Inazu, N., Satoh, T. Biochem. Pharmacol. (1994) [Pubmed]
  17. hCG-stimulated ovarian carbonyl reductase in relation to preovulatory ovarian follicular growth. Inazu, N., Fujii, T. J. Reprod. Fertil. (1998) [Pubmed]
 
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