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Chemical Compound Review

Prestwick_422     2,3-dihydroxybutanedioic acid; 1-methyl-2...

Synonyms: SureCN11213456, AC1O4WGW, HMS1568L05, HMS2981G08, MLS001249418, ...
 
 
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Disease relevance of PYRANTEL TARTRATE

  • A combination of pyrantel tartrate (106 mg/kg of body weight) and carbadox (55 mg/kg of body weight) in ground feed was fed to 20 weaned pigs (av wt, 14.4 kg) for 42 days [1].
  • Equine protozoal myeloencephalitis (EPM) is the most important protozoal disease of horses in the United States. Some horse owners and equine clinicians believe that horses which are on daily pyrantel tartrate at 2.64mg/kg for helminth prophylaxis are less likely to develop EPM [2].
  • The use of pyrantel tartrate (106 mg/kg of feed) as a continuous feed medication was evaluated in 848 finishing hogs for efficacy in preventing Ascaris suum infections, and in reducing liver fibrosis and liver condemnation at slaughter, associated with A suum infections [3].
  • In contrast, oral administration of pyrantel tartrate (25 mg/kg, an anthelmintic dosage level) did not lower blood cholinesterase activity, but rather, increased the toxicity by lowering the LD50 of levamisole from 39.8 mg/kg to 27.5 mg/kg [4].
 

High impact information on PYRANTEL TARTRATE

 

Gene context of PYRANTEL TARTRATE

  • Carbadox (CBX), an antibacterial agent, and pyrantel tartrate (PT), an anthelmintic, are formulated either separately or together in swine feeds [9].
 

Analytical, diagnostic and therapeutic context of PYRANTEL TARTRATE

  • The new method involves: (a) leaching of drug from feed with methanolic NaCl solution, (b) removal of interfering substances by ion pair liquid-liquid extraction and high performance liquid chromatography, and (c) quantitation of pyrantel tartrate by monitoring the ultraviolet absorption of the effluent stream at 313nm [10].

References

  1. Effect of pyrantel tartrate and carbadox on acquisition of the swine kidneyworm (Stephanurus dentatus) and other parasites by pigs on contaminated lots. Stewart, T.B., Marti, O.G., Hale, O.M., Lomax, L.G. Am. J. Vet. Res. (1979) [Pubmed]
  2. Determination of the activity of pyrantel tartrate against Sarcocystis neurona in gamma-interferon gene knockout mice. Lindsay, D.S., Dubey, J.P. Vet. Parasitol. (2001) [Pubmed]
  3. Prophylactic medication with pyrantel to prevent liver condemnation in pigs naturally exposed to Ascaris infections. Kennedy, T.J., Conway, D.P., Bliss, D.H. Am. J. Vet. Res. (1980) [Pubmed]
  4. Drug interactions of levamisole with pyrantel tartrate and dichlorvos in pigs. Hsu, W.H. Am. J. Vet. Res. (1981) [Pubmed]
  5. Successful treatment of Capillaria hepatica infection in an acutely ill adult. Pereira, V.G., Mattosinho Franca, L.C. Am. J. Trop. Med. Hyg. (1983) [Pubmed]
  6. Cyathostomes in horses in Canada resistant to pyrantel salts and effectively removed by moxidectin. Slocombe, J.O., de Gannes, R.V. Vet. Parasitol. (2006) [Pubmed]
  7. Controlled efficacy study of the bioequivalence of Strongid C and generic pyrantel tartrate in horses. Valdez, R.A., DiPietro, J.A., Paul, A.J., Lock, T.F., Hungerford, L.L., Todd, K.S. Vet. Parasitol. (1995) [Pubmed]
  8. Comparison of daily and monthly pyrantel treatment in yearling thoroughbreds and the protective effect of strategic medication of mares on their foals. Herd, R.P., Majewski, G.A. Vet. Parasitol. (1994) [Pubmed]
  9. A collaborative study: high-pressure liquid chromatographic determination of carbadox and pyrantel tartrate in animal feeds. Thorpe, V.A. Journal of chromatographic science. (1988) [Pubmed]
  10. High performance liquid chromatographic method fo pyrantel tartrate in swine feeds and supplements. Goras, J.T. Journal - Association of Official Analytical Chemists. (1981) [Pubmed]
 
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