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Disease relevance of Encephalomyelitis


High impact information on Encephalomyelitis

  • High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice [6].
  • In contrast, the effector phase of the immune response, as measured by the release of soluble CD8, coincides with the appearance and disappearance of the rash and occurs within the nervous system during encephalomyelitis [7].
  • Spontaneous proliferation of mononuclear cells and levels of soluble CD8 were similar in patients with uncomplicated disease, pneumonia, or encephalomyelitis, but soluble interleukin-2 receptor levels were lower in patients with encephalomyelitis (2312 +/- 314 vs. 3455 +/- 247 units per milliliter in uncomplicated measles; P = 0.01) [7].
  • The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis [8].
  • These results show that the N-terminal MBP-specific T lymphocytes that mediate autoimmune encephalomyelitis are a small population with a limited repertoire; they all recognise the same combination of MHC and target [9].

Chemical compound and disease context of Encephalomyelitis


Biological context of Encephalomyelitis


Anatomical context of Encephalomyelitis


Gene context of Encephalomyelitis


Analytical, diagnostic and therapeutic context of Encephalomyelitis


  1. QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2. Encinas, J.A., Wicker, L.S., Peterson, L.B., Mukasa, A., Teuscher, C., Sobel, R., Weiner, H.L., Seidman, C.E., Seidman, J.G., Kuchroo, V.K. Nat. Genet. (1999) [Pubmed]
  2. Myelin basic protein as an encephalitogen in encephalomyelitis and polyneuritis following rabies vaccination. Hemachudha, T., Griffin, D.E., Giffels, J.J., Johnson, R.T., Moser, A.B., Phanuphak, P. N. Engl. J. Med. (1987) [Pubmed]
  3. Autoimmune encephalomyelitis ameliorated by AMPA antagonists. Smith, T., Groom, A., Zhu, B., Turski, L. Nat. Med. (2000) [Pubmed]
  4. Genetics of susceptibility to chronic experimental encephalomyelitis and arthritis. Holmdahl, R. Curr. Opin. Immunol. (1998) [Pubmed]
  5. Measles encephalomyelitis: lack of evidence of viral invasion of the central nervous system and quantitative study of the nature of demyelination. Gendelman, H.E., Wolinsky, J.S., Johnson, R.T., Pressman, N.J., Pezeshkpour, G.H., Boisset, G.F. Ann. Neurol. (1984) [Pubmed]
  6. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Lafaille, J.J., Nagashima, K., Katsuki, M., Tonegawa, S. Cell (1994) [Pubmed]
  7. Immune activation in measles. Griffin, D.E., Ward, B.J., Jauregui, E., Johnson, R.T., Vaisberg, A. N. Engl. J. Med. (1989) [Pubmed]
  8. The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis. Sommer, N., Löschmann, P.A., Northoff, G.H., Weller, M., Steinbrecher, A., Steinbach, J.P., Lichtenfels, R., Meyermann, R., Riethmüller, A., Fontana, A. Nat. Med. (1995) [Pubmed]
  9. T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Zamvil, S.S., Mitchell, D.J., Moore, A.C., Kitamura, K., Steinman, L., Rothbard, J.B. Nature (1986) [Pubmed]
  10. A polyalanine peptide with only five native myelin basic protein residues induces autoimmune encephalomyelitis. Gautam, A.M., Pearson, C.I., Smilek, D.E., Steinman, L., McDevitt, H.O. J. Exp. Med. (1992) [Pubmed]
  11. Acute autoimmune encephalomyelitis in mice. II. Susceptibility is controlled by the combination of H-2 and histamine sensitization genes. Linthicum, D.S., Frelinger, J.A. J. Exp. Med. (1982) [Pubmed]
  12. Inhibition of autoimmune encephalomyelitis by a tetracycline. Popovic, N., Schubart, A., Goetz, B.D., Zhang, S.C., Linington, C., Duncan, I.D. Ann. Neurol. (2002) [Pubmed]
  13. Antigen presentation by astrocytes primes rat T lymphocytes for apoptotic cell death. A model for T-cell apoptosis in vivo. Gold, R., Schmied, M., Tontsch, U., Hartung, H.P., Wekerle, H., Toyka, K.V., Lassmann, H. Brain (1996) [Pubmed]
  14. Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice. Bachmann, R., Eugster, H.P., Frei, K., Fontana, A., Lassmann, H. Am. J. Pathol. (1999) [Pubmed]
  15. Immunity to TCR peptides in multiple sclerosis. II. T cell recognition of V beta 5.2 and V beta 6.1 CDR2 peptides. Chou, Y.K., Morrison, W.J., Weinberg, A.D., Dedrick, R., Whitham, R., Bourdette, D.N., Hashim, G., Offner, H., Vandenbark, A.A. J. Immunol. (1994) [Pubmed]
  16. MHC class II-regulated central nervous system autoaggression and T cell responses in peripheral lymphoid tissues are dissociated in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Weissert, R., de Graaf, K.L., Storch, M.K., Barth, S., Linington, C., Lassmann, H., Olsson, T. J. Immunol. (2001) [Pubmed]
  17. Monoclonal anti-I-A antibody reverses chronic paralysis and demyelination in Theiler's virus-infected mice: critical importance of timing of treatment. Friedmann, A., Frankel, G., Lorch, Y., Steinman, L. J. Virol. (1987) [Pubmed]
  18. Disparate regions of envelope protein regulate syncytium formation versus spongiform encephalopathy in neurological disease induced by murine leukemia virus TR. Murphy, S.L., Honczarenko, M.J., Dugger, N.V., Hoffman, P.M., Gaulton, G.N. J. Virol. (2004) [Pubmed]
  19. Cognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats. D'Intino, G., Paradisi, M., Fernandez, M., Giuliani, A., Aloe, L., Giardino, L., Calzà, L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  20. Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice. Offner, H., Adlard, K., Bebo, B.F., Schuster, J., Burrows, G.G., Buenafe, A.C., Vandenbark, A.A. J. Immunol. (1998) [Pubmed]
  21. Myelin/oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis in common marmosets: the encephalitogenic T cell epitope pMOG24-36 is presented by a monomorphic MHC class II molecule. Brok, H.P., Uccelli, A., Kerlero De Rosbo, N., Bontrop, R.E., Roccatagliata, L., de Groot, N.G., Capello, E., Laman, J.D., Nicolay, K., Mancardi, G.L., Ben-Nun, A., Hart, B.A. J. Immunol. (2000) [Pubmed]
  22. Superoxide prevents nitric oxide-mediated suppression of helper T lymphocytes: decreased autoimmune encephalomyelitis in nicotinamide adenine dinucleotide phosphate oxidase knockout mice. van der Veen, R.C., Dietlin, T.A., Hofman, F.M., Pen, L., Segal, B.H., Holland, S.M. J. Immunol. (2000) [Pubmed]
  23. Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. Hilliard, B.A., Mason, N., Xu, L., Sun, J., Lamhamedi-Cherradi, S.E., Liou, H.C., Hunter, C., Chen, Y.H. J. Clin. Invest. (2002) [Pubmed]
  24. Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis. Waldner, H., Sobel, R.A., Howard, E., Kuchroo, V.K. J. Immunol. (1997) [Pubmed]
  25. Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis. Poliani, P.L., Brok, H., Furlan, R., Ruffini, F., Bergami, A., Desina, G., Marconi, P.C., Rovaris, M., Uccelli, A., Glorioso, J.C., Penna, G., Adorini, L., Comi, G., 't Hart, B., Martino, G. Hum. Gene Ther. (2001) [Pubmed]
  26. Kinetics of cytokine mRNA expression in the central nervous system following lethal and nonlethal coronavirus-induced acute encephalomyelitis. Parra, B., Hinton, D.R., Lin, M.T., Cua, D.J., Stohlman, S.A. Virology (1997) [Pubmed]
  27. The role of IL-10 in mouse hepatitis virus-induced demyelinating encephalomyelitis. Lin, M.T., Hinton, D.R., Parra, B., Stohlman, S.A., van der Veen, R.C. Virology (1998) [Pubmed]
  28. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Zhang, Z.J., Davidson, L., Eisenbarth, G., Weiner, H.L. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  29. Characterization of the antigen specificity and TCR repertoire, and TCR-based DNA vaccine therapy in myelin basic protein-induced autoimmune encephalomyelitis in DA rats. Miyakoshi, A., Yoon, W.K., Jee, Y., Matsumoto, Y. J. Immunol. (2003) [Pubmed]
  30. Blood levels of kinins in experimental allergic encephalomyelitis. Germain, L., Barabe, J., Galeano, C. J. Neuroimmunol. (1986) [Pubmed]
  31. Ethinyl estradiol treats collagen-induced arthritis in DBA/1LacJ mice by inhibiting the production of TNF-alpha and IL-1beta. Subramanian, S., Tovey, M., Afentoulis, M., Krogstad, A., Vandenbark, A.A., Offner, H. Clin. Immunol. (2005) [Pubmed]
  32. Effectiveness of intravenous immunoglobulin treatment in adult patients with steroid-resistant monophasic or recurrent acute disseminated encephalomyelitis. Marchioni, E., Marinou-Aktipi, K., Uggetti, C., Bottanelli, M., Pichiecchio, A., Soragna, D., PiccoloG, n.u.l.l., Imbesi, F., Romani, A., Ceroni, M. J. Neurol. (2002) [Pubmed]
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