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Chemical Compound Review

AC1O4WLF     2-[2-[(1R)-1-[3- cyclopropyloxy-4...

Synonyms: L-869299, 2fm5
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Disease relevance of M99


High impact information on M99

  • GspB and Hsa are homologous serine-rich surface glycoproteins of Streptococcus gordonii strains M99 and Challis, respectively, that mediate the binding of these organisms to platelet membrane glycoprotein (GP) Ibalpha [5].
  • Loss of GspB surface expression is associated with a significant reduction in the binding of M99 to human platelets, suggesting that it may be an adhesin [1].
  • M99 virulence was attenuated when delivered by intubation, but fully virulent by i.p. injection [3].
  • Two had an extra G-like chromosome, which in case M99 consisted mainly of 16p (he had also a small Y chromosome shared by his father and brother), and in case M8 of 9p [6].
  • 21. Three of the patients (M18, M49 and M99) can be regarded as type specimens for new syndromes in the sense that the chromosome anomalies causing the respective phenotypes have been identified for the first time [6].

Associations of M99 with other chemical compounds


  1. An accessory sec locus of Streptococcus gordonii is required for export of the surface protein GspB and for normal levels of binding to human platelets. Bensing, B.A., Sullam, P.M. Mol. Microbiol. (2002) [Pubmed]
  2. Effect of thrombocytopenia on the early course of streptococcal endocarditis. Sullam, P.M., Frank, U., Yeaman, M.R., Täuber, M.G., Bayer, A.S., Chambers, H.F. J. Infect. Dis. (1993) [Pubmed]
  3. Regulation of Vibrio anguillarum empA metalloprotease expression and its role in virulence. Denkin, S.M., Nelson, D.R. Appl. Environ. Microbiol. (2004) [Pubmed]
  4. The immobilization of wapiti with etorphine hydrochloride. Magonigle, R.A., Stauber, E.H., Vaughn, H.W. J. Wildl. Dis. (1977) [Pubmed]
  5. Binding of the Streptococcus gordonii surface glycoproteins GspB and Hsa to specific carbohydrate structures on platelet membrane glycoprotein Ibalpha. Takamatsu, D., Bensing, B.A., Cheng, H., Jarvis, G.A., Siboo, I.R., López, J.A., Griffiss, J.M., Sullam, P.M. Mol. Microbiol. (2005) [Pubmed]
  6. Cytogenetics of 50 patients with mental retardation and multiple congenital anomalies and 50 normal subjects. Madison blind study IV. Magnelli, N.C. Clin. Genet. (1976) [Pubmed]
  7. Immobilization of coastal grizzly bears with etorphine hydrochloride. Herbert, D.M., Lay, D.W., Turnbull, W.G. J. Wildl. Dis. (1980) [Pubmed]
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