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MeSH Review

Aortic Valve

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Disease relevance of Aortic Valve


High impact information on Aortic Valve


Chemical compound and disease context of Aortic Valve


Biological context of Aortic Valve


Anatomical context of Aortic Valve


Associations of Aortic Valve with chemical compounds

  • These findings indicate that heart failure in aortic valve disease is associated with low PCr, which could be due to loss of intracellular creatine [25].
  • Because leaflet calcification occurs in areas of lipoprotein deposition, we hypothesised that 3-hydroxy-3-methylglutaryl-coenzyme A (HMG COA) reductase inhibitors (statins) might slow aortic valve calcium (AVC) accumulation [10].
  • Our investigations studied ethanol pretreatment of glutaraldehyde cross-linked porcine aortic valves as a new approach to prevent cuspal calcification [21].
  • In other postoperative evaluations that included ergometric stress with isoproterenol and pacing, induced hemodynamic changes after aortic valve replacement were predictable and consistent with regard to both direction and magnitude, and they differed characteristically according to the type of stress used [26].
  • Platelet survival time was measured (by the chromium-51 method) in 73 patients with aortic valve disease [27].

Gene context of Aortic Valve


Analytical, diagnostic and therapeutic context of Aortic Valve


  1. Nifedipine in asymptomatic patients with severe aortic regurgitation and normal left ventricular function. Scognamiglio, R., Rahimtoola, S.H., Fasoli, G., Nistri, S., Dalla Volta, S. N. Engl. J. Med. (1994) [Pubmed]
  2. Increased guanylate cyclase activity is associated with an increase in cyclic guanosine 3',5'-monophosphate in left ventricular hypertrophy. Sadoff, J.D., Scholz, P.M., Tse, J., Weiss, H.R. J. Clin. Invest. (1996) [Pubmed]
  3. Comparison of the cardiocirculatory effects of exercise and isoproterenol in children with pulmonary or aortic valve stenosis. Truccone, N.J., Steeg, C.N., Dell, R., Gersony, W.M. Circulation (1977) [Pubmed]
  4. Imaging experimental infective endocarditis with indium-111-labeled blood cellular components. Riba, A.L., Thakur, M.L., Gottschalk, A., Andriole, V.T., Zaret, B.L. Circulation (1979) [Pubmed]
  5. Antibiotic prophylaxis of experimental endocarditis after dental extractions. Malinverni, R., Overholser, C.D., Bille, J., Glauser, M.P. Circulation (1988) [Pubmed]
  6. M-mode and two-dimensional echocardiographic abnormalities in systemic lupus erythematosus. Klinkhoff, A.V., Thompson, C.R., Reid, G.D., Tomlinson, C.W. JAMA (1985) [Pubmed]
  7. Cardiovascular surgery in Jehovah's Witnesses. Report of 542 operations without blood transfusion. Ott, D.A., Cooley, D.A. JAMA (1977) [Pubmed]
  8. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. Ishibashi, S., Goldstein, J.L., Brown, M.S., Herz, J., Burns, D.K. J. Clin. Invest. (1994) [Pubmed]
  9. In vivo influx of free and esterified plasma cholesterol into human aortic tissue without atherosclerotic lesions. Stender, S., Hjelms, E. J. Clin. Invest. (1984) [Pubmed]
  10. HMG CoA reductase inhibitor (statin) and aortic valve calcium. Shavelle, D.M., Takasu, J., Budoff, M.J., Mao, S., Zhao, X.Q., O'Brien, K.D. Lancet (2002) [Pubmed]
  11. Comparison of anticoagulation regimens after Carpentier-Edwards aortic or mitral valve replacement. Blair, K.L., Hatton, A.C., White, W.D., Smith, L.R., Lowe, J.E., Wolfe, W.G., Young, W.G., Oldham, H.N., Douglas, J.M., Glower, D.D. Circulation (1994) [Pubmed]
  12. Hyperlipidaemia and aortic valve disease. Rossebø, A.B., Pedersen, T.R. Curr. Opin. Lipidol. (2004) [Pubmed]
  13. Antithrombotic therapy in patients with valvular heart disease and prosthetic heart valves. Chesebro, J.H., Adams, P.C., Fuster, V. J. Am. Coll. Cardiol. (1986) [Pubmed]
  14. Angiotensin-converting enzyme inhibitors and change in aortic valve calcium. O'Brien, K.D., Probstfield, J.L., Caulfield, M.T., Nasir, K., Takasu, J., Shavelle, D.M., Wu, A.H., Zhao, X.Q., Budoff, M.J. Arch. Intern. Med. (2005) [Pubmed]
  15. Cogan syndrome: studies in thirteen patients, long-term follow-up, and a review of the literature. Haynes, B.F., Kaiser-Kupfer, M.I., Mason, P., Fauci, A.S. Medicine (Baltimore) (1980) [Pubmed]
  16. Activation of the cardiac renin-angiotensin system and increased myocardial collagen expression in human aortic valve disease. Fielitz, J., Hein, S., Mitrovic, V., Pregla, R., Zurbrügg, H.R., Warnecke, C., Schaper, J., Fleck, E., Regitz-Zagrosek, V. J. Am. Coll. Cardiol. (2001) [Pubmed]
  17. Progression of human aortic valve stenosis is associated with tenascin-C expression. Satta, J., Melkko, J., Pöllänen, R., Tuukkanen, J., Pääkkö, P., Ohtonen, P., Mennander, A., Soini, Y. J. Am. Coll. Cardiol. (2002) [Pubmed]
  18. Ascorbyl free radical: a noninvasive marker of oxidative stress in human open-heart surgery. Pietri, S., Séguin, J.R., d'Arbigny, P.D., Culcasi, M. Free Radic. Biol. Med. (1994) [Pubmed]
  19. Acetylcholine-induced membrane potential changes in endothelial cells of rabbit aortic valve. Ohashi, M., Satoh, K., Itoh, T. Br. J. Pharmacol. (1999) [Pubmed]
  20. Mechanism of efficacy of 2-amino oleic acid for inhibition of calcification of glutaraldehyde-pretreated porcine bioprosthetic heart valves. Chen, W., Schoen, F.J., Levy, R.J. Circulation (1994) [Pubmed]
  21. Prevention of bioprosthetic heart valve calcification by ethanol preincubation. Efficacy and mechanisms. Vyavahare, N., Hirsch, D., Lerner, E., Baskin, J.Z., Schoen, F.J., Bianco, R., Kruth, H.S., Zand, R., Levy, R.J. Circulation (1997) [Pubmed]
  22. Fibronectin biosynthesis and cell-surface expression by cardiac and non-cardiac endothelial cells. Johnson, C.M., Helgeson, S.C. Am. J. Pathol. (1993) [Pubmed]
  23. Role of glutaraldehyde in calcification of porcine aortic valve fibroblasts. Kim, K.M., Herrera, G.A., Battarbee, H.D. Am. J. Pathol. (1999) [Pubmed]
  24. Coronary artery dimensions in primary and secondary left ventricular hypertrophy. Kaufmann, P., Vassalli, G., Lupi-Wagner, S., Jenni, R., Hess, O.M. J. Am. Coll. Cardiol. (1996) [Pubmed]
  25. Detection of low phosphocreatine to ATP ratio in failing hypertrophied human myocardium by 31P magnetic resonance spectroscopy. Conway, M.A., Allis, J., Ouwerkerk, R., Niioka, T., Rajagopalan, B., Radda, G.K. Lancet (1991) [Pubmed]
  26. Hemodynamics alterations induced by isoproterenol and pacing after aortic valve replacement with the Björk-Shiley or St. Jude medical prosthesis. Thormann, J., Gottwik, M., Schlepper, M., Hehrlein, F. Circulation (1981) [Pubmed]
  27. Platelet survival time following aortic valve replacement. Steele, P., Weily, H., Davies, H., Ppppas, G., Genton, E. Circulation (1975) [Pubmed]
  28. Interleukin-1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis. Kaden, J.J., Dempfle, C.E., Grobholz, R., Tran, H.T., Kiliç, R., Sarikoç, A., Brueckmann, M., Vahl, C., Hagl, S., Haase, K.K., Borggrefe, M. Atherosclerosis (2003) [Pubmed]
  29. Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation. Fedak, P.W., de Sa, M.P., Verma, S., Nili, N., Kazemian, P., Butany, J., Strauss, B.H., Weisel, R.D., David, T.E. J. Thorac. Cardiovasc. Surg. (2003) [Pubmed]
  30. Beta-actin cannot be used as a control for gene expression in ovine interstitial cells derived from heart valves. Yperman, J., De Visscher, G., Holvoet, P., Flameng, W. J. Heart Valve Dis. (2004) [Pubmed]
  31. Mutations in NOTCH1 cause aortic valve disease. Garg, V., Muth, A.N., Ransom, J.F., Schluterman, M.K., Barnes, R., King, I.N., Grossfeld, P.D., Srivastava, D. Nature (2005) [Pubmed]
  32. Expression and activity of matrix metalloproteinase-2 in calcific aortic stenosis. Kaden, J.J., Vocke, D.C., Fischer, C.S., Grobholz, R., Brueckmann, M., Vahl, C.F., Hagl, S., Haase, K.K., Dempfle, C.E., Borggrefe, M. Zeitschrift für Kardiologie. (2004) [Pubmed]
  33. Inhibition by diphosphonate compounds of calcification of porcine bioprosthetic heart valve cusps implanted subcutaneously in rats. Levy, R.J., Hawley, M.A., Schoen, F.J., Lund, S.A., Liu, P.Y. Circulation (1985) [Pubmed]
  34. Pulsatile flow characteristics of aortic valve porcine heterografts in man. Christie, L.G., Nichols, W.W., Pepine, C.J., Curry, R.C., Conti, C.R. Circulation (1978) [Pubmed]
  35. Serotonin mechanisms in heart valve disease I: serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cells. Jian, B., Xu, J., Connolly, J., Savani, R.C., Narula, N., Liang, B., Levy, R.J. Am. J. Pathol. (2002) [Pubmed]
  36. Percutaneous single- and double-balloon aortic valvotomy in adolescents and young adults with congenital aortic stenosis. Ribeiro, P.A., Al Zaibag, M., Halim, M., Al Kasab, S. Eur. Heart J. (1988) [Pubmed]
  37. An ultrastructural study of the origin and function of basophilic degeneration in human cardiac muscle--cardiac colloid. Type 1. Gregory, M.A., Olmesdahl, P.J., Whitton, I.D. J. Pathol. (1982) [Pubmed]
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