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Chemical Compound Review

CHEMBL88222     (5Z,8Z,11Z,13E)-15- hydroperoxyicosa-5,8,11...

Synonyms: CHEBI:243332, LS-176614, AC1O5MZ5, C20H32O4, 15-Hpete, ...
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Disease relevance of Arachidonic acid 15-hydroperoxide


High impact information on Arachidonic acid 15-hydroperoxide


Anatomical context of Arachidonic acid 15-hydroperoxide


Associations of Arachidonic acid 15-hydroperoxide with other chemical compounds


Gene context of Arachidonic acid 15-hydroperoxide


  1. The inhibition of PGI2 synthetase within the arterial wall by 15-hydroperoxyarachidonic acid enhances local white platelet thrombosis. Bourgain, R.H. Haemostasis (1980) [Pubmed]
  2. Biosynthesis and metabolism of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid by human umbilical vein endothelial cells. Hopkins, N.K., Oglesby, T.D., Bundy, G.L., Gorman, R.R. J. Biol. Chem. (1984) [Pubmed]
  3. Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom. Marnett, L.J., Siedlik, P.H., Ochs, R.C., Pagels, W.R., Das, M., Honn, K.V., Warnock, R.H., Tainer, B.E., Eling, T.E. Mol. Pharmacol. (1984) [Pubmed]
  4. Enhancement of ATPase activity by a lipid peroxide of arachidonic acid in rat brain microvessels. Koide, T., Asano, T., Matsushita, H., Takakura, K. J. Neurochem. (1986) [Pubmed]
  5. The vasodilatation induced by hydroperoxy metabolites of arachidonic acid in the rat mesenteric and pulmonary circulation. d'Alarcao, M., Corey, E.J., Cunard, C., Ramwell, P., Uotila, P., Vargas, R., Wroblewska, B. Br. J. Pharmacol. (1987) [Pubmed]
  6. Oxidation of myoglobin in isolated adult rat cardiac myocytes by 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid. Walters, F.P., Kennedy, F.G., Jones, D.P. FEBS Lett. (1983) [Pubmed]
  7. Possible mechanisms of 15-hydroperoxyarachidonic acid-induced contraction of the canine basilar artery in vitro. Koide, T., Neichi, T., Takato, M., Matsushita, H., Sugioka, K., Nakano, M., Hata, S. J. Pharmacol. Exp. Ther. (1982) [Pubmed]
  8. Endothelium-dependent inhibitory effects of acetylcholine, adenosine triphosphate, thrombin and arachidonic acid in the canine femoral artery. De Mey, J.G., Claeys, M., Vanhoutte, P.M. J. Pharmacol. Exp. Ther. (1982) [Pubmed]
  9. Suicide inactivation of porcine leukocyte 12-lipoxygenase associated with its incorporation of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid derivative. Kishimoto, K., Nakamura, M., Suzuki, H., Yoshimoto, T., Yamamoto, S., Takao, T., Shimonishi, Y., Tanabe, T. Biochim. Biophys. Acta (1996) [Pubmed]
  10. Radical acetoacetate oxidation by myeloperoxidase, lactoperoxidase, prostaglandin synthetase, and prostacyclin synthetase: implications for atherosclerosis. Harrison, J.E., Saeed, F.A. Biochemical medicine. (1983) [Pubmed]
  11. Contraction of the canine basilar artery following linoleic, arachidonid 13-hydroperoxylinoleic, or 15-hydroperoxyarachidonic acid. Koide, T., Noda, Y., Hata, S., Sugioka, K., Kobayashi, S., Nakano, M. Proc. Soc. Exp. Biol. Med. (1981) [Pubmed]
  12. Prostaglandin I2 synthesis and elevation of cyclic AMP levels in 3T3 fibroblasts. Claesson, H.E. Biochim. Biophys. Acta (1980) [Pubmed]
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