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Gene Review

Ptgis  -  prostaglandin I2 (prostacyclin) synthase

Mus musculus

Synonyms: Cyp8, Cyp8a1, Pgi2, Pgis, Prostacyclin synthase, ...
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Disease relevance of Ptgis


High impact information on Ptgis


Biological context of Ptgis


Anatomical context of Ptgis

  • Northern blot analyses showed that the PGIS mRNA was expressed in a decreasing order in the resident, and casein- and BCG-elicited macrophages [7].
  • METHODS AND RESULTS: Exposure of cultured human aortic endothelial cells to clinically relevant concentrations of CD40L (20 to 80 ng/mL) dose-dependently increased the production of superoxide (O2*-), decreased nitric oxide (NO) bioactivity, and increased PGIS nitration [10].
  • COX-1, COX-2 and PGIS were expressed in 4-cell stage embryos and beyond; they were present in the inner cell mass and the trophectoderm of the blastocysts [11].

Associations of Ptgis with chemical compounds


Other interactions of Ptgis

  • In situ hybridization analysis showed that the expression of mRNAs for PGIS and TXS was ascribable not only to the alteration of the expression levels of both mRNAs in the each macrophage but also to the changes in subpopulations of the cells expressing these mRNAs [7].
  • In addition, mutation of two Sp1 recognition motifs residing at bases -297 to -289 and -197 to -192 markedly reduced the basal PGIS promoter activity and retarded the band in a gel mobility shift assay [8].


  1. Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke. Nana-Sinkam, S.P., Lee, J.D., Sotto-Santiago, S., Stearman, R.S., Keith, R.L., Choudhury, Q., Cool, C., Parr, J., Moore, M.D., Bull, T.M., Voelkel, N.F., Geraci, M.W. Am. J. Respir. Crit. Care Med. (2007) [Pubmed]
  2. Pulmonary prostacyclin synthase overexpression by adenovirus transfection and in transgenic mice. Geraci, M., Gao, B., Shepherd, D., Allard, J., Curiel, D., Westcott, J., Voelkel, N. Chest (1998) [Pubmed]
  3. Targets for gene therapy of vein grafts. Newby, A.C., Baker, A.H. Curr. Opin. Cardiol. (1999) [Pubmed]
  4. Enhanced angiogenesis and improvement of neuropathy by cotransfection of human hepatocyte growth factor and prostacyclin synthase gene. Koike, H., Morishita, R., Iguchi, S., Aoki, M., Matsumoto, K., Nakamura, T., Yokoyama, C., Tanabe, T., Ogihara, T., Kaneda, Y. FASEB J. (2003) [Pubmed]
  5. Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivo. Nie, H., Wu, J.L., Zhang, M., Xu, J., Zou, M.H. Diabetes (2006) [Pubmed]
  6. Involvement of caveolae and caveolae-like domains in signalling, cell survival and angiogenesis. Massimino, M.L., Griffoni, C., Spisni, E., Toni, M., Tomasi, V. Cell. Signal. (2002) [Pubmed]
  7. Inverse gene expression of prostacyclin and thromboxane synthases in resident and activated peritoneal macrophages. Kuwamoto, S., Inoue, H., Tone, Y., Izumi, Y., Tanabe, T. FEBS Lett. (1997) [Pubmed]
  8. Cloning and characterization of 5'-flanking region of mouse prostacyclin synthase gene. Ohkawara, S., Shimonishi, M., Tanabe, T., Yokoyama, C. Biochim. Biophys. Acta (2000) [Pubmed]
  9. Enhanced therapeutic angiogenesis by cotransfection of prostacyclin synthase gene or optimization of intramuscular injection of naked plasmid DNA. Hiraoka, K., Koike, H., Yamamoto, S., Tomita, N., Yokoyama, C., Tanabe, T., Aikou, T., Ogihara, T., Kaneda, Y., Morishita, R. Circulation (2003) [Pubmed]
  10. CD40 ligand-dependent tyrosine nitration of prostacyclin synthase in vivo. Davis, B., Zou, M.H. Circulation (2005) [Pubmed]
  11. Cyclooxygenase-2-derived endogenous prostacyclin enhances mouse embryo hatching. Huang, J.C., Wun, W.S., Goldsby, J.S., Matijevic-Aleksic, N., Wu, K.K. Hum. Reprod. (2004) [Pubmed]
  12. Prostaglandin I2 synthesis and elevation of cyclic AMP levels in 3T3 fibroblasts. Claesson, H.E. Biochim. Biophys. Acta (1980) [Pubmed]
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