Disease relevance of Reprodin

• Twenty hours after luprostiol application, goats were continuously observed in order to record the following parameters: parturition, dystocia incidence, placental delivery and live births [1].

High impact information on Reprodin

• On the opposite, in G and D, contractile agents (except the highest luprostiol doses) did not stimulate myometrium contractions [2].
• To remove corpora lutea, one group of goats (CL-, n=41) received 7.5 mg of luprostiol on days 7 and 8 of the estrous cycle [3].
• Luteolysis was induced 96 hours after the treatments began by a single injection of 7.5 mg luprostiol [4].
• Synchronization of estrus after treatment with Luprostiol in beef cows and in beef and dairy heifers [5].
• The first trial was to evaluate parturition induced by various dosages of luprostiol compared with those of lutalyse or vehicle [6].

Biological context of Reprodin

• Luprostiol can cause luteolysis and estrous synchrony in Brahman cattle.(ABSTRACT TRUNCATED AT 250 WORDS)[7]
• In a second trial, 20 crossbred pregnant sows received either vehicle or luprostiol (7.5 mg) on Day 112 of gestation [6].

Associations of Reprodin with other chemical compounds

• Heifers not observed in estrus within 5 d were randomly assigned to receive 15 mg Luprostiol or 25 mg Lutalyse [5].
• One hundred and twenty crossbred Angus heifers, after exhibiting a 17- to 23-d estrous cycle, were placed into six groups of 20 heifers each and administered 2 ml i.m. propylene glycol containing either 0 (controls), 3.75, 7.5, 15.0 or 30.0 mg of luprostiol, or saline containing 0.5 mg cloprostenol (Groups 1 through 6, respectively) [8].
• A trial was conducted to evaluate the ability of a prostaglandin analog, Luprostiol (LP), to synchronize estrus in Brahman cows and heifers [7].
• Based on serum progesterone concentration and/or interval from treatment to estrus, 15 and 30 mg of luprostiol effectively regressed corpora lutea (100%) when administered between 6.5 and 8.0 d after estrus, and the estrous response and conception rate for these two groups equalled or exceeded that of the control and cloprostenol groups [8].
• Multiparous lactating beef cows were observed for estrus and randomly assigned to one of four Luprostiol (13, thia-PG-F(2)alpha analog) treatment groups receiving 3.8 (LI), 7.5 (LII), 15 (LIII) or 30 (LIV) mg Luprostiol, respectively, or to an untreated control group (C), or to a positive control group (E) receiving 500 mcg Estrumate [9].

Analytical, diagnostic and therapeutic context of Reprodin

• Each treatment group was inseminated according to the manufacturer's recommendations for fixed-time artificial insemination (A.I.; luprostiol, 72h after the second injection, SMB and CIDR-B 48h after implant/device removal) [10].

References