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Chemical Compound Review

Lutalyse     2-amino-2- (hydroxymethyl)propane-1,3- diol;...

Synonyms: Dinolytic, Ensaprost, Zinoprost, Prostamate, Prostalmon F, ...
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Disease relevance of Enzaprost F


Psychiatry related information on Enzaprost F


High impact information on Enzaprost F

  • On Days 9-11, the rats received twice daily injections of saline, PGF (Lutalyse, 250 microg/injection), or PRL (312 microg/injection) to induce luteal regression [5].
  • Sows were assigned to one of eight treatments on d 90 of gestation that included variables such as parity (1 vs. >/=3), dietary fat (0 vs. 10%), and farrowing (natural vs. induction via lutalyse on d 112) [6].
  • On the test day (day 46 or 47 of pseudopregnancy) animals were injected with 3 ml saline (n=5) or 15 mg of PGF(2alpha) (Lutalyse, Upjohn; n=6) intramuscularly [7].
  • Interaction of hCG and Lutalyse on steroidogenesis of bovine luteal cells [8].
  • In conclusion, the luteotropic effects of hCG were incapable of preventing Lutalyse-induced regression of the corpus luteum, and treatment of animals with hCG prior to Lutalyse administration could not prevent the significant decrease in responsiveness of luteal cells in vitro [8].

Biological context of Enzaprost F


Anatomical context of Enzaprost F

  • The effect of lutalyse on the training of sexually inexperienced boars for semen collection [4].
  • Cows that had 3 consecutive high tests (>5 ng/ml) were assumed to have persistent corpora lutea (CL) and were treated with 5 ml PGF(2)alpha (Lutalyse, 5 mg/ml) [14].
  • The obtained results expressed in per cent indicate that Estrumate exerts a greater effects on the parietal cells in the abomasal mucosa in sheep and Lutalyse stimulates more strongly the chief cells, as reflected in increased proteolytic power of the studied juice [3].

Associations of Enzaprost F with other chemical compounds


Gene context of Enzaprost F

  • Holstein heifers were treated with PGF2 alpha (25 mg Lutalyse) on Day 6 or Day 7 of the oestrous cycle and corpora lutea were collected 0 h, 2 h, 12 h, and 24 h later (n = 6, 4, 4, and 4 respectively) [20].
  • It is concluded that either SMB containing norgestomet or a CIDR containing progesterone alters luteal secretion of PGE2, Lutalyse lowers luteal weights in the induced estrous cycle, and NO or ET-1 given alone are not luteolytic agents [21].
  • A study was conducted on 40 buffalo-cows, assigned randomly, immediately after calving into three groups: group I (n = 10) injected with saline and taken as control; group II (n = 15) received 25 mg PGF2 alpha/animal (Lutalyse); group III (n = 15) received 25 mg PGF2 alpha + 25 i.u. oxytocin/animal (Syntocinon), single i.m. dose [22].

Analytical, diagnostic and therapeutic context of Enzaprost F


  1. The therapeutic activity, post-treatment fertility and safety of prostaglandin F2alpha-Tham salt in clinically anoestrous mares: a review. Nelson, A.M. Equine Vet. J. (1976) [Pubmed]
  2. The effect of infectious bovine rhinotracheitis vaccine on reproductive efficiency in cattle vaccinated during estrus. Chiang, B.C., Smith, P.C., Nusbaum, K.E., Stringfellow, D.A. Theriogenology (1990) [Pubmed]
  3. Comparison of the effects of two prostaglandin F2 alpha analogues-estrumate and lutalyse on the volume, activity, and proteolytic power of the abomasal juice in sheep. Dejneka, J., Lukaszewska, J., Romański, K. Acta physiologica Polonica. (1981) [Pubmed]
  4. The effect of lutalyse on the training of sexually inexperienced boars for semen collection. Kozink, D.M., Estienne, M.J., Harper, A.F., Knight, J.W. Theriogenology (2002) [Pubmed]
  5. Actions of prostaglandin F2alpha and prolactin on intercellular adhesion molecule-1 expression and monocyte/macrophage accumulation in the rat corpus luteum. Olson, K.K., Anderson, L.E., Wiltbank, M.C., Townson, D.H. Biol. Reprod. (2001) [Pubmed]
  6. Dietary fat during pregnancy and lactation increases milk fat and insulin-like growth factor I concentrations and improves neonatal growth rates in swine. Averette, L.A., Odle, J., Monaco, M.H., Donovan, S.M. J. Nutr. (1999) [Pubmed]
  7. c-fos mRNA expression associated with PGF(2alpha)-induced nest-building behaviour in female pigs. Burne, T.H., Murfitt, P.J., Gilbert, C.L. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  8. Interaction of hCG and Lutalyse on steroidogenesis of bovine luteal cells. Litch, S.J., Condon, W.A. Mol. Cell. Endocrinol. (1988) [Pubmed]
  9. Efficiency of the OVATEC unit for estrus detection and calf sex control in beef cows. Wehner, G.R., Wood, C., Tague, A., Barker, D., Hubert, H. Anim. Reprod. Sci. (1997) [Pubmed]
  10. Effect of FSH treatment on LH and FSH receptors in chronic cystic-ovarian-diseased dairy cows. Brown, J.L., Schoenemann, H.M., Reeves, J.J. J. Anim. Sci. (1986) [Pubmed]
  11. Dosage response evaluation of luprostiol administered to pregnant sows. Diehl, J.R., Newby, T.J. Theriogenology (1989) [Pubmed]
  12. Synchronization of estrus in virgin beef heifers using melengestrol acetate and PGF2alpha: an efficacy comparison of cloprostenol and dinoprost tromethamine. Salverson, R.R., DeJarnette, J.M., Marshall, C.E., Wallace, R.A. Theriogenology (2002) [Pubmed]
  13. Effect of interval from melengestrol acetate to prostaglandin F2 alpha on timed and synchronized pregnancy rates of beef heifers and cows. Kesler, D.J., Faulkner, D.B., Shirley, R.B., Dyson, T.S., Ireland, F.A., Ott, R.S. J. Anim. Sci. (1996) [Pubmed]
  14. Use of cow-side progesterone tests to improve reproductive performance of high-producing dairy cows. Bajema, D.H., Hoffman, M.P., Aitchison, T.E., Ford, S.P. Theriogenology (1994) [Pubmed]
  15. Effects of prostaglandin F2alpha treatment on the behavior of pseudopregnant pigs in an extensive environment. Gilbert, C.L., Murfitt, P.J., Boulton, M.I., Pain, J., Burne, T.H. Hormones and behavior. (2000) [Pubmed]
  16. Responses of different doses of prostaglandin F(2) alpha on estrus induction, fertility and progesterone levels in subestrous buffaloes. Chauhan, F.S., Sharma, R.D., Singh, G.B. Theriogenology (1982) [Pubmed]
  17. Synchronization of estrus after treatment with Luprostiol in beef cows and in beef and dairy heifers. Plata, N.I., Spitzer, J.C., Thompson, C.E., Henricks, D.M., Reid, M.P., Newby, T.J. Theriogenology (1990) [Pubmed]
  18. Effect of altrenogest and Lutalyse on parturition control, plasma progesterone, unconjugated estrogen and 13,14-dihydro-15-keto-prostaglandin F2 alpha in sows. Guthrie, H.D., Meckley, P.E., Young, E.P., Hartsock, T.G. J. Anim. Sci. (1987) [Pubmed]
  19. Estrogen-induced pseudopregnancy in gilts: Its use in estrus synchronization and subsequent influence on litter response. Zavy, M.T., Geisert, R.D., Buchanan, D.S., Norton, S.A. Theriogenology (1988) [Pubmed]
  20. Concentrations of cytochrome P450 cholesterol side-chain cleavage enzyme and 3 beta-hydroxysteroid dehydrogenase during prostaglandin F2 alpha-induced luteal regression in cattle. Rodgers, R.J., Vella, C.A., Young, F.M., Tian, X.C., Fortune, J.E. Reprod. Fertil. Dev. (1995) [Pubmed]
  21. Effects of estrous synchronization on response to nitric oxide donors, nitric oxide synthase inhibitors, and endothelin-1 in vitro. Weems, Y.S., Randel, R.D., Tatman, S., Lewis, A.W., Neuendorff, D.A., Weems, C.W. Prostaglandins Other Lipid Mediat. (2004) [Pubmed]
  22. Role of oxytocin and/or PGF2 alpha on breeding efficiency in buffaloes. el-Baghdady, Y.R., Fattouh, E.S., el-Ekhnawy, K.I., Ayoub, M.M., Bedeir, L.H. Br. Vet. J. (1990) [Pubmed]
  23. Endogenous hormone response and fertility in dairy heifers after treatment with Lutalyse and GnRH. Kazmer, G.W., Barnes, M.A., Halman, R.D., Dickey, J.F. Theriogenology (1981) [Pubmed]
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