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MeSH Review


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Disease relevance of Luteolysis


Psychiatry related information on Luteolysis


High impact information on Luteolysis

  • In many nonprimate mammalian species, cyclical regression of the corpus luteum (luteolysis) is caused by the episodic pulsatile secretion of uterine PGF2alpha, which acts either locally on the corpus luteum by a countercurrent mechanism or, in some species, via the systemic circulation [7].
  • Regardless of the mechanism, intraovarian luteolysis in primates (progesterone withdrawal) appears to be the primary stimulus for the subsequent production of endometrial prostaglandins associated with menstruation [7].
  • Neither the timing nor the severity of PMS symptoms was altered by mifepristone-induced menses or luteolysis [8].
  • Mechanisms controlling corpus luteum function in sheep, cows, nonhuman primates, and women especially in relation to the time of luteolysis [9].
  • Induction of luteolysis in the human with a long-acting analog of luteinizing hormone-releasing factor [10].

Chemical compound and disease context of Luteolysis


Biological context of Luteolysis

  • Because key ovarian functions, such as ovulation and luteolysis, represent aseptic inflammatory responses, and because the theca cell is the functional equivalent of the Leydig cell, we explored the CRH presence in the ovary, first, by specific CRH immunohistochemistry of adult cycling female Sprague-Dawley rat ovaries [12].
  • COX-1-deficient mice demonstrated impaired luteolysis, as evidenced by elevated serum progesterone concentration and ovarian histology late in gestation, and delayed induction of uterine oxytocin receptors [13].
  • The separation of signaling pathways that govern differentiation and survival in the ovary thereby provides a mechanism by which progesterone production, which is absolutely essential for the maintenance of pregnancy, can continue despite the cessation of proliferation of luteal cells and their commitment to cell death (luteolysis) [14].
  • Despite high P and E(2) concentrations during the early luteal phase in all three groups, luteolysis started prematurely, presumably because of excessive negative steroid feedback resulting in suppressed pituitary LH release [15].
  • We suggest that gap junctional communication between the cells of the primate and human corpus luteum may be important in hormone synthesis and secretion and may be involved in the process of luteolysis through luteal cell apoptosis [16].

Anatomical context of Luteolysis

  • In conclusion, our results suggest that both gonadotropins (FSH and hCG) and cytokines (TGFbeta1 and M-CSF) may be involved in the support of luteal function via suppression of apoptosis, and that TNFalpha and PGF2alpha may contribute to ovarian dysfunction and/or luteal regression via its induction in human luteinized granulosa cells [17].
  • In addition, CRH is secreted by the human placenta, rat Leydig cells, and rat and human ovaries, where it may participate in the inflammatory processes of ovulation and luteolysis, and/or the regulation of steroidogenesis [18].
  • Lipid accumulation is a hallmark of corpus luteum regression and we characterized lipids stored in rat corpora lutea of pregnancy between days 21 and 24 post coitum, the period of luteolysis [19].
  • The infusion of recombinant bovine interferon-alpha I 1 into the uterus of cyclic cows from day 15.5 to 21 after estrus delayed luteolysis [20].
  • Development of antral follicles in cattle after prostaglandin-induced luteolysis: changes in serum hormones, steroids in follicular fluid, and gonadotropin receptors [21].

Associations of Luteolysis with chemical compounds


Gene context of Luteolysis

  • In contrast, simultaneous oxytocin and COX-1 deficiency restored the normal onset of labor by allowing luteolysis in the absence of elevated PGF2alpha production [13].
  • The purpose of the present study was to examine the effects on IGFBP-3 production of prostaglandin (PG)-E2, a compound known to stimulate luteal function and prevent/delay luteal regression (a luteotropic compound), and PGF2 alpha, a compound known to be luteolytic [26].
  • Dynamic changes in mitogen-activated protein kinase (MAPK) activities in the corpus luteum of the bonnet monkey (Macaca radiata) during development, induced luteolysis, and simulated early pregnancy: a role for p38 MAPK in the regulation of luteal function [27].
  • These results suggest that COX-1-derived PGs are responsible for the induction of luteolysis, and that COX-2-derived PGs play a role in the final pathway of parturition [28].
  • Thus, the aims of this investigation were to examine whether IL-6 plays a role in luteolysis and, more specifically, to determine whether luteal cells express the IL-6 gene, whether this expression is developmentally and hormonally regulated in pregnancy, and whether the corpus luteum could be a target for IL-6 action [29].

Analytical, diagnostic and therapeutic context of Luteolysis


  1. Effects of controlled heat stress on ovarian function of dairy cattle. 1. Lactating cows. Wilson, S.J., Marion, R.S., Spain, J.N., Spiers, D.E., Keisler, D.H., Lucy, M.C. J. Dairy Sci. (1998) [Pubmed]
  2. Prostaglandin F2alpha induced luteolysis, hypothermia, and abortions in beagle bitches. Concannon, P.W., Hansel, W. Prostaglandins (1977) [Pubmed]
  3. Release of proinflammatory cytokines related to luteolysis and the periparturient acute phase response in prostaglandin-induced parturition in cows. Koets, A.P., de Schwartz, N., Tooten, P., Kankofer, M., Broekhuijsen-Davies, J.M., Rutten, V.P., van Leengoed, L.A., Taverne, M.A., Gruys, E. Theriogenology (1998) [Pubmed]
  4. Immunohistochemical localization of prolactin in functioning and regressing corpus luteum of pituitary autotransplanted rats. Martín de las Mulas, J., Aguilar, E., Sánchez-Criado, J.E. Histol. Histopathol. (1986) [Pubmed]
  5. The possible mode of action of iproniazid. I. Differential luteolytic effect of iproniazid before and after the establishment of placental adolescence. Biswas, L., Pal, A.K., Chatterjee, A. Endokrinologie. (1975) [Pubmed]
  6. Angiotensin II interacts with prostaglandin F2alpha and endothelin-1 as a local luteolytic factor in the bovine corpus luteum in vitro. Hayashi, K., Miyamoto, A. Biol. Reprod. (1999) [Pubmed]
  7. Luteolysis: a neuroendocrine-mediated event. McCracken, J.A., Custer, E.E., Lamsa, J.C. Physiol. Rev. (1999) [Pubmed]
  8. Lack of effect of induced menses on symptoms in women with premenstrual syndrome. Schmidt, P.J., Nieman, L.K., Grover, G.N., Muller, K.L., Merriam, G.R., Rubinow, D.R. N. Engl. J. Med. (1991) [Pubmed]
  9. Mechanisms controlling corpus luteum function in sheep, cows, nonhuman primates, and women especially in relation to the time of luteolysis. Auletta, F.J., Flint, A.P. Endocr. Rev. (1988) [Pubmed]
  10. Induction of luteolysis in the human with a long-acting analog of luteinizing hormone-releasing factor. Casper, R.F., Yen, S.S. Science (1979) [Pubmed]
  11. The effects of estrogen and progesterone on prostaglandins and integrin beta 3 (beta3) subunit expression in primary cultures of bovine endometrial cells. Kimmins, S., Lim, H.C., Parent, J., Fortier, M.A., MacLaren, L.A. Domest. Anim. Endocrinol. (2003) [Pubmed]
  12. Immunoreactive corticotropin-releasing hormone and its binding sites in the rat ovary. Mastorakos, G., Webster, E.L., Friedman, T.C., Chrousos, G.P. J. Clin. Invest. (1993) [Pubmed]
  13. Opposing actions of prostaglandins and oxytocin determine the onset of murine labor. Gross, G.A., Imamura, T., Luedke, C., Vogt, S.K., Olson, L.M., Nelson, D.M., Sadovsky, Y., Muglia, L.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  14. Adenovirus-directed expression of a nonphosphorylatable mutant of CREB (cAMP response element-binding protein) adversely affects the survival, but not the differentiation, of rat granulosa cells. Somers, J.P., DeLoia, J.A., Zeleznik, A.J. Mol. Endocrinol. (1999) [Pubmed]
  15. Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with recombinant follicle-stimulating hormone and GnRH antagonist cotreatment. Beckers, N.G., Macklon, N.S., Eijkemans, M.J., Ludwig, M., Felberbaum, R.E., Diedrich, K., Bustion, S., Loumaye, E., Fauser, B.C. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  16. Expression of gap junction protein connexin-43 in the human and baboon (Papio anubis) corpus luteum. Khan-Dawood, F.S., Yang, J., Dawood, M.Y. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  17. Gonadotropins and cytokines affect luteal function through control of apoptosis in human luteinized granulosa cells. Matsubara, H., Ikuta, K., Ozaki, Y., Suzuki, Y., Suzuki, N., Sato, T., Suzumori, K. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  18. Presence of immunoreactive corticotropin-releasing hormone in human endometrium. Mastorakos, G., Scopa, C.D., Kao, L.C., Vryonidou, A., Friedman, T.C., Kattis, D., Phenekos, C., Rabin, D., Chrousos, G.P. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  19. Lipid metabolism in regressing rat corpora lutea of pregnancy. Strauss, J.F., Seifter, E., Lien, E.L., Goodman, D.B., Stambaugh, R.L. J. Lipid Res. (1977) [Pubmed]
  20. Prolongation of luteal lifespan in cows by intrauterine infusion of recombinant bovine alpha-interferon. Plante, C., Hansen, P.J., Thatcher, W.W. Endocrinology (1988) [Pubmed]
  21. Development of antral follicles in cattle after prostaglandin-induced luteolysis: changes in serum hormones, steroids in follicular fluid, and gonadotropin receptors. Ireland, J.J., Roche, J.F. Endocrinology (1982) [Pubmed]
  22. Effects of alloxan-induced diabetes on corpus luteum function in the pseudopregnant rat. Garris, D.R., Whitehead, D.S., Morgan, C.R. Diabetes (1984) [Pubmed]
  23. Synergism of estrogen and bromergocryptine in the induction of luteolysis in cynomolgus monkeys (Macaca fascicularis). Castracane, V.D., Shaikh, A.A. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  24. Hydrogen peroxide evokes antisteroidogenic and antigonadotropic actions in human granulosa luteal cells. Endo, T., Aten, R.F., Leykin, L., Behrman, H.R. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  25. Regulation of gonadotropin-releasing hormone (GnRH) receptor messenger ribonucleic acid and GnRH receptors during the early preovulatory period in the ewe. Turzillo, A.M., Campion, C.E., Clay, C.M., Nett, T.M. Endocrinology (1994) [Pubmed]
  26. Divergent actions of prostaglandins-E2 and -F2 alpha on the regulation of insulin-like growth factor-binding protein-3 in luteinized granulosa cells. Grimes, R.W., Samaras, S.E., Hammond, J.M. Endocrinology (1993) [Pubmed]
  27. Dynamic changes in mitogen-activated protein kinase (MAPK) activities in the corpus luteum of the bonnet monkey (Macaca radiata) during development, induced luteolysis, and simulated early pregnancy: a role for p38 MAPK in the regulation of luteal function. Yadav, V.K., Medhamurthy, R. Endocrinology (2006) [Pubmed]
  28. Uterine expression of prostaglandin H2 synthase in late pregnancy and during parturition in prostaglandin F receptor-deficient mice. Tsuboi, K., Sugimoto, Y., Iwane, A., Yamamoto, K., Yamamoto, S., Ichikawa, A. Endocrinology (2000) [Pubmed]
  29. The expression of interleukin-6 in the pregnant rat corpus luteum and its regulation by progesterone and glucocorticoid. Telleria, C.M., Ou, J., Sugino, N., Ferguson, S., Gibori, G. Endocrinology (1998) [Pubmed]
  30. The relation between the effects of hysterectomy, decidual tissue, prolactin, or luteinizing hormone (LH) and the ability of indomethacin to prevent luteolysis in rats bearing LH-dependent corpora lutea. Sanchez-Criado, J., Rothchild, I. Endocrinology (1986) [Pubmed]
  31. Regulation of blood flow to the rabbit corpus luteum: effects of estradiol and human chorionic gonadotropin. Wiltbank, M.C., Gallagher, K.P., Dysko, R.C., Keyes, P.L. Endocrinology (1989) [Pubmed]
  32. Expression of cytokine messenger ribonucleic acids in the bovine corpus luteum. Petroff, M.G., Petroff, B.K., Pate, J.L. Endocrinology (1999) [Pubmed]
  33. Immunocytochemical localization of relaxin in corpora lutea of sows throughout the estrous cycle. Ali, S.M., McMurtry, J.P., Bagnell, C.A., Bryant-Greenwood, G.D. Biol. Reprod. (1986) [Pubmed]
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