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Chemical Compound Review

PubChem5853     (2S)-propane-1,2-diol

Synonyms: AG-F-51302, CHEBI:29002, HMDB06213, ANW-29836, AC-14033, ...
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Disease relevance of propylene glycol


Psychiatry related information on propylene glycol

  • These laboratory measures and the clinical signs of vomiting, lethargy, and increased frequency of drinking might complicate the diagnosis or monitoring of some intoxications (such as ethylene glycol) in dogs that have previously received AC suspension containing propylene glycol, glycerol, or both as vehicles [6].

High impact information on propylene glycol

  • A single intraperitoneal injection of vehicle (propylene glycol), OCT, or 1,25-(OH)2D3 (1.0 micrograms/rat) increased calcium by 0.32, 0.30, and 1.40 mg/dl, respectively [7].
  • We observe that intramolecular electron transfer in the bianthryl molecule from the locally excited (LE) to the charge-transfer (CT) state, which requires solvent relaxation and does not occur in vitrified polar solutions, is dramatically facilitated in low-temperature propylene glycol glass by the red-edge excitation [8].
  • On the other hand, propylene glycol, an alcohol sulfotransferase inhibitor, had a profound inhibitory effect on DNA methylation induced by NMHEA, very little effect on the formation of N7-(2-hydroxyethyl)guanine, but a very strong effect on the O6-hydroxyethylguanine lesions [9].
  • However, propylene glycol was found to depress all the levels of alkylation in the brachymorphic mice, except for N7-(2-hydroxyethyl)guanine, as was observed in rats.(ABSTRACT TRUNCATED AT 400 WORDS)[9]
  • Subsequent studies showed that the human cDNA clone complemented an ATR-deficient bacterial mutant for Ado-B12-dependent growth on 1,2-propanediol [10].

Chemical compound and disease context of propylene glycol


Biological context of propylene glycol


Anatomical context of propylene glycol


Associations of propylene glycol with other chemical compounds

  • The supercooled liquid is geometrically restricted by the reverse micelles of a glass-forming PG/AOT/decalin microemulsion, with the intramicellar dynamics being probed by triplet state solvation dynamics [25].
  • Aerosolization of cyclosporin A (300 mg in 4.8 ml propylene glycol) using an AeroTech II jet nebulizer was instituted daily for 12 consecutive days followed by a maintenance regimen of 3 d/wk [26].
  • Hairless mice were treated with either oleic acid/propylene glycol and iontophoresis separately or together [27].
  • To reduce the non-urea-dependent ATPase activity (v(blank)) and to increase the urea-dependent activity, 1,2-propanediol was included [28].
  • We report here a method for determination of relative (Deltadelta(13)C) and absolute (delta(13)C) intramolecular isotope ratios using the volatile lactic acid analogue propylene glycol as a model compound, measured by on-line gas chromatography-pyrolysis coupled to GC-combustion-isotope ratio mass spectrometry [29].

Gene context of propylene glycol


Analytical, diagnostic and therapeutic context of propylene glycol


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  14. Synthesis of a nickel tetracarboranylphenylporphyrin for boron neutron-capture therapy: biodistribution and toxicity in tumor-bearing mice. Miura, M., Micca, P.L., Fisher, C.D., Heinrichs, J.C., Donaldson, J.A., Finkel, G.C., Slatkin, D.N. Int. J. Cancer (1996) [Pubmed]
  15. Coenzyme B12-dependent diol dehydratase: regulation of apoenzyme synthesis in Klebsiella pneumoniae (Aerobacter aerogenes) ATCC 8724. Toraya, T., Honda, S., Kuno, S., Fukui, S. J. Bacteriol. (1978) [Pubmed]
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  29. Determination of Intramolecular delta(13)C from Incomplete Pyrolysis Fragments. Evaluation of Pyrolysis-Induced Isotopic Fractionation in Fragments from the Lactic Acid Analogue Propylene Glycol. Wolyniak, C.J., Sacks, G.L., Metzger, S.K., Brenna, J.T. Anal. Chem. (2006) [Pubmed]
  30. Mechanism of hilA repression by 1,2-propanediol consists of two distinct pathways, one dependent on and the other independent of catabolic production of propionate, in Salmonella enterica serovar Typhimurium. Nakayama, S., Watanabe, H. J. Bacteriol. (2006) [Pubmed]
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