High impact information on cloprostenol

• Nineteen of the 20 animals exhibited estrus after 56-72 h of the second injection of estrumate [1].
• Manipulation of estrous cycle in dwarf goat (Capra hircus) using estrumate under different management conditions [1].
• In Experiment 1, cyclic buffalo (n = 10) were assigned to 2 equal groups receiving either 500 micrograms i.m. cloprostenol (Estrumate, ICI) or 125 micrograms cloprostenol injected intravulvosubmucosal (ivsm) ipsilateral to the side of the corpus luteum (CL) on Day 11 of an induced estrous cycle [2].
• There was no relationship between serum progesterone concentration and pregnancy rate in the Estrumate recipients (P>0.10) [3].
• Eighteen cows were superovulated by injecting 3000 IU of PMSG during the luteal phase, followed 48h later with an injection of Estrumate [4].

Biological context of cloprostenol

• One hundred thirty-five crossbred heifers were used to compare the effectiveness of Estrumate and Syncro-Mate B in synchronizing estrus in recipient heifers for transfer of demi-embryos [3].
• The length of the induced or natural estrous cycle (20+/-1 days) was not affected by the estrumate treatment, nor by the environmental and nutritional conditions [1].
• Fertility of Friesian heifers after luteolysis with a prostaglandin analogue (ICI 80996) [5].
• However, two inseminations 56 and 66 h after the final ICI 80996 injection gave an even more elevated lambing rate (61.9 p. 100) [6].

Associations of cloprostenol with other chemical compounds

• Artificial insemination of subtropical commercial beef cattle following synchronization with cloprostenol (ICI 80996): I. Fertility [7].
• Two prostaglandins, Estrumate and Dinolytic, and two progestagens, PRID and Norgestomet were compared for their effectiveness in controlling estrus in dairy cows [8].
• Multiparous lactating beef cows were observed for estrus and randomly assigned to one of four Luprostiol (13, thia-PG-F(2)alpha analog) treatment groups receiving 3.8 (LI), 7.5 (LII), 15 (LIII) or 30 (LIV) mg Luprostiol, respectively, or to an untreated control group (C), or to a positive control group (E) receiving 500 mcg Estrumate [9].
• Concentrations of PGF2alpha in ovarian venous plasma (OVP) were 4-13 times higher than those of jugular venous plasma (JVP) (P < 0.001) during the period of the experiment, and increased from 24 h after treatment with Estrumate (P < 0.05) [10].

Gene context of cloprostenol

• Cyclooxygenase (COX)-2 mRNA expression increased (P < 0.05) at 2 and 24 h after treatment with Estrumate [10].
• At the 72nd hour, all donors received 2 ml of Estrumate (I.C.I.) and, at estrus, 1000 i.u. of HCG (Profasi, Serono) 24 hours apart [11].

Analytical, diagnostic and therapeutic context of cloprostenol

• Synchronization of estrus in embryo transfer recipients receiving demi-embryos with Syncro-Mate B or estrumate [3].
• Thirty six buffalo showing normal reproductive cyclas were given a single intramuscular injection of prostaglandin F(2alpha)- thamsalt (PGF(2alpha)) and Estrumate on day 9 or 15 of the estrous cycle in order to induce estrus [12].
• Synchronization of oestrus in buffalo-heifers with estrumate & fertility with frozen semen [13].

References