Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1LCVE1 disodium;(2R,5R,6S)-6-[[(2R)- 2-amino-2...

Synonyms:

Wang, J. et al., Pajchel, G. et al., Garratty, G. et al., Pearl, R.H. et al., Randhawa, B. et al.

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Disease relevance of D02065

More significantly, the administration of ART together with ampicillin or unasyn (a complex of ampicillin and sulbactam) decreased mortality from 100 to 66.7% or 33.3%, respectively, in mice subjected to a lethal live E. coli challenge [1].
We reported previously that an injectable form of ampicillin/sulbactam, Unasyn, was bactericidal to Mycobacterium leprae multiplying in mouse foot pads [2].
Those with perforated appendicitis received pre- and postoperative antibiotics, primarily ampicillin/gentamicin/clindamycin or Flagyl (41%), cefoxitin (34%), or Unasyn (15%) [3].

High impact information on D02065

A high incidence (39%) of positive direct antiglobulin tests (DATs) has been reported in patients taking Unasyn [ampicillin sodium plus sulbactam sodium (a beta-lactamase inhibitor)] [4].
A rapid, capillary electrophoresis method was evaluated for determination of amoxicillin and clavulanic acid in Augmentin as well as ampicillin and sulbactam in Unasyn preparations for injections [5].

References

The antimalarial artemisinin synergizes with antibiotics to protect against lethal live Escherichia coli challenge by decreasing proinflammatory cytokine release. Wang, J., Zhou, H., Zheng, J., Cheng, J., Liu, W., Ding, G., Wang, L., Luo, P., Lu, Y., Cao, H., Yu, S., Li, B., Zhang, L. Antimicrob. Agents Chemother. (2006) [Pubmed]
Bactericidal action of oral ampicillin/sulbactam against Mycobacterium leprae. Randhawa, B., Harris, E.B., Prabhakaran, K. J. Antimicrob. Chemother. (1999) [Pubmed]
Pediatric appendectomy. Pearl, R.H., Hale, D.A., Molloy, M., Schutt, D.C., Jaques, D.P. J. Pediatr. Surg. (1995) [Pubmed]
Positive direct antiglobulin tests and haemolytic anaemia following therapy with beta-lactamase inhibitor containing drugs may be associated with nonimmunologic adsorption of protein onto red blood cells. Garratty, G., Arndt, P.A. Br. J. Haematol. (1998) [Pubmed]
CE versus LC for simultaneous determination of amoxicillin/clavulanic acid and ampicillin/sulbactam in pharmaceutical formulations for injections. Pajchel, G., Pawłowski, K., Tyski, S. Journal of pharmaceutical and biomedical analysis. (2002) [Pubmed]

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