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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Coombs' Test

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Disease relevance of Coombs' Test


High impact information on Coombs' Test


Chemical compound and disease context of Coombs' Test


Biological context of Coombs' Test


Anatomical context of Coombs' Test


Associations of Coombs' Test with chemical compounds


Gene context of Coombs' Test

  • Furthermore, the reaction was accompanied by a strongly positive Coombs test and increased TNF-alpha and IL-10 serum levels which returned to normal following anti-inflammatory drug administration [29].
  • DNA antibody, and direct antiglobulin test were observed in 30%, 14%, 7% and 12%, respectively, and a CD4/CD8 ratio < 1 was observed in 20% [30].
  • Direct coombs test and protein C, C3, and C4 were also within normal levels [31].
  • The mixed antiglobulin test detected antibody in the sera of patients on chronic dialysis two to four times more frequently than did either the immune adherence test or the most sensitive modification of the microlymphocytotoxicity test which was utilized [32].
  • The direct antiglobulin test was positive in all but one case; this finding coincided with elevated unconjugated bilirubin in 14 cases and decreased haptoglobin levels in 15 cases [33].

Analytical, diagnostic and therapeutic context of Coombs' Test


  1. Positive direct antiglobulin tests and immune hemolytic anemia in patients receiving procainamide. Kleinman, S., Nelson, R., Smith, L., Goldfinger, D. N. Engl. J. Med. (1984) [Pubmed]
  2. Immune thrombocytopenia. Use of a Coombs antiglobulin test to detect IgG and C3 on platelets. Cines, D.B., Schreiber, A.D. N. Engl. J. Med. (1979) [Pubmed]
  3. Impaired reticuloendothelial function in patients treated with methyldopa. Kelton, J.G. N. Engl. J. Med. (1985) [Pubmed]
  4. Valproic-acid-induced pancytopenia and Coombs test positivity. Kaya, I.S., Dilmen, U., Toppare, M., Senses, D.A., Prentice, H.G. Lancet (1991) [Pubmed]
  5. Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis. Chalmers, A., Thompson, D., Stein, H.E., Reid, G., Patterson, A.C. Ann. Intern. Med. (1982) [Pubmed]
  6. The C3b/C4b receptor is recognized by the Knops, McCoy, Swain-langley, and York blood group antisera. Moulds, J.M., Nickells, M.W., Moulds, J.J., Brown, M.C., Atkinson, J.P. J. Exp. Med. (1991) [Pubmed]
  7. Successful treatment of pure red cell aplasia with rituximab in patients with chronic lymphocytic leukemia. Ghazal, H. Blood (2002) [Pubmed]
  8. An explanation for nonimmunologic adsorption of proteins onto red blood cells: Schiff's base reactions. Jamin, D., Demers, J., Shulman, I., Lam, H.T., Momparler, R. Blood (1986) [Pubmed]
  9. Reduced numbers of complement receptor type 1 on erythrocytes are associated with increased levels of anticardiolipin antibodies. Findings in patients with systemic lupus erythematosus and the antiphospholipid syndrome. Hammond, A., Rudge, A.C., Loizou, S., Bowcock, S.J., Walport, M.J. Arthritis Rheum. (1989) [Pubmed]
  10. Safety of cefepime: a new extended-spectrum parenteral cephalosporin. Neu, H.C. Am. J. Med. (1996) [Pubmed]
  11. Severe autoimmune cytopenias in treatment-naive hepatitis C virus infection: clinical description of 35 cases. Ramos-Casals, M., García-Carrasco, M., López-Medrano, F., Trejo, O., Forns, X., López-Guillermo, A., Muñoz, C., Ingelmo, M., Font, J. Medicine (Baltimore) (2003) [Pubmed]
  12. Immune hemolytic anemia associated with tolmetin and suprofen. van Dijk, B.A., Rico, P.B., Hoitsma, A., Kunst, V.A. Transfusion (1989) [Pubmed]
  13. Preclinical safety studies of cefmetazole. Moe, J.B., Piper, R.C., Tanase, H., Sotani, K., Manabe, J. J. Antimicrob. Chemother. (1989) [Pubmed]
  14. Mycophenolate mofetil in the treatment of autoimmune HCV-associated haematological disorders showing steroid resistance or dependence. Ierardi, E., Rendina, M., Francavilla, R., Barone, M., Castellaneta, A., Panella, C., Francavilla, A., Cuomo, R. J. Viral Hepat. (2003) [Pubmed]
  15. The detection by enzyme-linked immunosorbent assays of non-complement-fixing HLA antibodies in transfusion medicine. Lubenko, A., Rodi, K.M. Transfusion (1998) [Pubmed]
  16. The increase of blood anticardiolipin antibody depends on the underlying etiology in cerebral ischemia. Chen, W.H., Kao, Y.F., Lan, M.Y., Chang, Y.Y., Chen, S.S., Liu, J.S. Clin. Appl. Thromb. Hemost. (2005) [Pubmed]
  17. In vitro production of anti-RBC antibodies and cytokines in chronic lymphocytic leukemia. Barcellini, W., Montesano, R., Clerici, G., Zaninoni, A., Imperiali, F.G., Calori, R., Cortelezzi, A., Zanella, A. Am. J. Hematol. (2002) [Pubmed]
  18. Maternal anti-D prophylaxis during pregnancy does not cause neonatal haemolysis. Maayan-Metzger, A., Schwartz, T., Sulkes, J., Merlob, P. Archives of disease in childhood. Fetal and neonatal edition. (2001) [Pubmed]
  19. Double phototherapy in jaundiced term infants with hemolysis. Thaithumyanon, P., Visutiratmanee, C. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. (2002) [Pubmed]
  20. Current drug treatment options in neonatal hyperbilirubinaemia and the prevention of kernicterus. Rubaltelli, F.F. Drugs (1998) [Pubmed]
  21. Oxaliplatin-induced immune pancytopenia. Taleghani, B.M., Meyer, O., Fontana, S., Ahrens, N., Novak, U., Borner, M.M., Salama, A. Transfusion (2005) [Pubmed]
  22. Positive antiglobulin tests due to intravenous immunoglobulin in patients who received bone marrow transplant. Robertson, V.M., Dickson, L.G., Romond, E.H., Ash, R.C. Transfusion (1987) [Pubmed]
  23. Monocyte monolayer assay (MMA) reactivity of alloantibodies reacting by the manual polybrene technique but not by an antiglobulin test. Lown, J., Willis, J. Transfusion medicine (Oxford, England) (1995) [Pubmed]
  24. Guillain-Barré syndrome: demonstration of antibodies to peripheral nerve tissue. Nyland, H., Aarli, J.A. Acta neurologica Scandinavica. (1978) [Pubmed]
  25. Rh blood group-specific antibodies in immune hemolytic anemia induced by nomifensine. Salama, A., Mueller-Eckhardt, C. Blood (1986) [Pubmed]
  26. Serologic profile of alphamethyldopa-induced hemolytic anemia: correlation between cell-bound IgM and hemolysis. Lalezari, P., Louie, J.E., Fadlallah, N. Blood (1982) [Pubmed]
  27. Bilirubin production in healthy term infants as measured by carbon monoxide in breath. Stevenson, D.K., Vreman, H.J., Oh, W., Fanaroff, A.A., Wright, L.L., Lemons, J.A., Verter, J., Shankaran, S., Tyson, J.E., Korones, S.B. Clin. Chem. (1994) [Pubmed]
  28. Positive direct antiglobulin tests due to clavulanic acid. Williams, M.E., Thomas, D., Harman, C.P., Mintz, P.D., Donowitz, G.R. Antimicrob. Agents Chemother. (1985) [Pubmed]
  29. Oxaliplatin-induced acute-onset thrombocytopenia, hemorrhage and hemolysis. Koutras, A.K., Makatsoris, T., Paliogianni, F., Kopsida, G., Onyenadum, A., Gogos, C.A., Mouzaki, A., Kalofonos, H.P. Oncology (2004) [Pubmed]
  30. Correlation between immunological abnormalities and prognosis in myelodysplastic syndrome patients. Okamoto, T., Okada, M., Mori, A., Saheki, K., Takatsuka, H., Wada, H., Tamura, A., Fujimori, Y., Takemoto, Y., Kanamaru, A., Kakishita, E. Int. J. Hematol. (1997) [Pubmed]
  31. Transient antiphospholipid syndrome in an infant with segmental small bowel infarction. Güvenç, B.H., Sarper, N., Tuzlaci, A., Günaltay, N. J. Pediatr. Surg. (2004) [Pubmed]
  32. A mixed antiglobulin test with kidney cells in suspension for IgG antibody in human allograft recipients. Pierce, J.C., Waller, M., Phibbs, M. Transplantation (1975) [Pubmed]
  33. Transfusion reaction. An immunologic hazard of blood transfusion. Pineda, A.A., Taswell, H.F., Brzica, S.M. Transfusion (1978) [Pubmed]
  34. A retrospective clinical study of canine leishmaniasis in 150 dogs naturally infected by Leishmania infantum. Ciaramella, P., Oliva, G., Luna, R.D., Gradoni, L., Ambrosio, R., Cortese, L., Scalone, A., Persechino, A. Vet. Rec. (1997) [Pubmed]
  35. An enzyme-linked antiglobulin test to quantify nanogram quantities of IgG on polystyrene microspheres. Greenwalt, T.J., Domino, M.M., Dumaswala, U.J. Vox Sang. (1992) [Pubmed]
  36. Evaluation of a new immunocapture test for the diagnosis of ovine brucellosis caused by Brucella melitensis. Durán-Ferrer, M., Mendoza, J., Osuna, A., Caporale, V., Lucas, A., León, L., Garrido, F. Vet. Rec. (2002) [Pubmed]
  37. The clinical significance of ABO blood group incompatibility. Madlon-Kay, D.J. Archives of family medicine. (1993) [Pubmed]
  38. Prevention of bilirubin encephalopathy. Bertini, G., Dani, C., Pezzati, M., Rubaltelli, F.F. Biol. Neonate (2001) [Pubmed]
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