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Chemical Compound Review

Fenfluramine, R-Isomer     (2R)-N-ethyl-1-[3- (trifluoromethyl)phenyl]...

Synonyms: l-Fenfluramine, CHEMBL438145, SureCN162006, CHEBI:521051, STOCK5S-44738, ...
 
 
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Psychiatry related information on Fenfluramine l-form

 

High impact information on Fenfluramine l-form

 

Biological context of Fenfluramine l-form

  • The kinetics of l-fenfluramine (l-F) are dose-dependent in man and rats, suggesting self-inhibition of metabolism and saturation of microsomal enzymes [8].
 

Anatomical context of Fenfluramine l-form

 

Analytical, diagnostic and therapeutic context of Fenfluramine l-form

References

  1. l-fenfluramine in tests of dominance and anxiety in the rat. File, S.E., Guardiola-Lemaitre, B.J. Neuropsychobiology (1988) [Pubmed]
  2. Clinical-pharmacological study with the two isomers (d-, l-) of fenfluramine and its comparison with chlorpromazine and d-amphetamine: psychometric and psychophysiological evaluation. Grünberger, J., Saletu, B., Linzmayer, L., Barbanoj, M.J. Methods and findings in experimental and clinical pharmacology. (1993) [Pubmed]
  3. Appetite suppressant drugs as inhibitors of human cytochromes P450: in vitro inhibition of P450-2D6 by D- and L-fenfluramine, but not phentermine. von Moltke, L.L., Greenblatt, D.J., Ciraulo, D.A., Grassi, J.M., Granda, B.W., Duan, S.X., Harmatz, J.S., Shader, R.I. Journal of clinical psychopharmacology. (1998) [Pubmed]
  4. l-fenfluramine and haloperidol in rats: a qEEG comparison. Sebban, C., Tesolin, B., Shvaloff, A., Lemaitre-Guardiola, B. Psychopharmacology (Berl.) (1989) [Pubmed]
  5. Effects of fenfluramine and antidepressants on protein kinase C activity in rat cortical synaptoneurosomes. Giambalvo, C.T., Price, L.H. Synapse (2003) [Pubmed]
  6. The effects of D- and L-fenfluramine (and their interactions with D-amphetamine) on psychomotor function and mood. Feeney, S., Goodall, E., Silverstone, T. International clinical psychopharmacology. (1996) [Pubmed]
  7. The prolactin response to d- and l-fenfluramine and to d-amphetamine in human subjects. Feeney, S., Goodall, E., Silverstone, T. International clinical psychopharmacology. (1993) [Pubmed]
  8. Effects of L-fenfluramine on rat liver drug-metabolizing enzymes. Conti, I., Tridico, R.V., Duan, L., Caccia, S. Res. Commun. Chem. Pathol. Pharmacol. (1991) [Pubmed]
  9. Effects of the l isomer of fenfluramine on dopamine mechanisms in rat brain: further studies. Invernizzi, R., Bertorelli, R., Consolo, S., Garattini, S., Samanin, R. Eur. J. Pharmacol. (1989) [Pubmed]
  10. Lack of self-administration of different fenfluramine isomers in rats. Dahl, C.B., Götestam, K.G. Addictive behaviors. (1989) [Pubmed]
  11. Fluorometric determination of DL-fenfluramine, DL-norfenfluramine and phentermine in plasma by achiral and chiral high-performance liquid chromatography. Kaddoumi, A., Nakashima, M.N., Nakashima, K. J. Chromatogr. B Biomed. Sci. Appl. (2001) [Pubmed]
 
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