Disease relevance of Flicker Fusion

• Exophoria of the eyes by the Maddox wing test was significantly increased by itraconazole, but the results of the digit symbol substitution test, critical flicker fusion test, postural sway tests and the visual analogue scale tests for subjective drowsiness and overall drug effect did not differ between the phases [1].
• OBJECTIVE: To determine the flicker fusion frequency in children and adolescents with insulin-dependent diabetes mellitus (IDDM) who did not have fluorescein angiographic signs of retinopathy [2].

Psychiatry related information on Flicker Fusion

• The effects of alprazolam (0.125 mg) taken twice a day on several cognitive and performance tasks (Pictures test, Digit-Symbol Substitution Test, Choice Reaction Time [CRT], Critical Flicker Fusion [CFF]) were investigated in healthy students [3].
• Short- and long-term memory (paired words associate and pictures test), psychomotor performances (critical flicker fusion frequency, choice reaction time, digit symbol substitution test), and postural sway were evaluated before and 1.5, 4, 6, and 8 h after the administration of a single dose of zolpidem (10 mg), triazolam (0.25 mg), and placebo [4].
• Plasma concentrations of zopiclone and psychometric tests, including simple and complex reaction time, and critical flicker fusion threshold, were performed at regular intervals after drug administration [5].

High impact information on Flicker Fusion

• Nicotine also improved the ability of DAT patients to detect a flickering light in a critical flicker fusion test [6].
• Modulation of the critical flicker fusion effects of serotonin reuptake inhibitors by concomitant pupillary changes [7].
• Ro 15-1788 dose dependently blocked the deficit in secondary memory produced by lorazepam, but also showed monotonic dose-related antagonism of its effects on indices of sedation (with the exception of the critical flicker fusion deficit, which was unaffected) [8].
• The performance of the chronic BZ users did not differ significantly from age- and sex-matched anxious subjects, except that critical flicker fusion (CFF) thresholds were lower and subjective ratings of tranquilization were higher in the BZ users [9].
• On all five performance assessments (choice reaction times, serial subtraction times, critical flicker fusion values), there was a consistent tendancy for clobazam performance to be comparatively better under high stress, and for placebo performance to be comparatively better under low stress [10].

Chemical compound and disease context of Flicker Fusion

• There were no significant differences between placebo and lorazepam on the free recall test and the critical flicker fusion frequency test, but lorazepam produced significant improvement on the digit symbol substitution test and the choice reaction time test [11].
• Similarly, restoration of higher mental function was significantly faster following propofol, measured by choice reaction time and critical flicker fusion threshold [12].
• The effects of six nightly doses of temazepam (20 mg), nitrazepam (10 mg) and placebo on saccadic eye movements, critical flicker fusion, choice reaction time and on subjective feelings were studied in a double blind cross-over study in eight volunteers [13].
• Compared with the placebo session, phenobarbital was found to induced CNS-depressing effects as assessed by visual analogue rating scales (VARS) and critical flicker fusion tests (CFF), whereas no significant effects were detected on choice reaction times, tappings, and digit symbol substitutions [14].
• Finally, the effects of desflurane, isoflurane, and propofol on postoperative psychomotor (e.g., Trieger test, choice reaction time) and cognitive (e.g., digit-symbol substitution test, critical flicker fusion test) function are remarkably similar [15].

Biological context of Flicker Fusion

• Triprolidine (10 mg) impaired visuo-motor coordination, reduced the number of substitutions on the digit symbol test, lowered the critical flicker fusion threshold and reduced dynamic visual acuity [16].
• The effects of the antipsychotic drug sulpiride on vigilance, as measured by choice reaction time and critical flicker fusion, and on heart-rate and skin conductance, were studied in healthy volunteers (n = 6) [17].
• The central effects of a neuropeptide, ACTH 4-9 analogue (Organon 2766), were studied in man using digit symbol substitution (DSS), symbol copying, digit span, electroencephalography and auditory evoked potentials, critical flicker fusion (CFF) and pupillary response to light [18].
• Before and after 12 days of taurine (3 g/day) or placebo supplementation, two identical 2.5-hr VDT work tests were performed while recording the P100, N75 and N145 latencies and P100 amplitude of pattern visual evoked potential (PVEP) and the frequency of critical flicker fusion (CFF) [19].

Associations of Flicker Fusion with chemical compounds

• Measurements on day 2 showed that some tolerance had developed to the diazepam-induced impairment of reactive and coordinative skills, but not to its effects on flicker fusion or on the extraocular muscle balance [20].
• Meperidine impaired reactive skills for as long as 3 hours and flicker-fusion discrimination and coordinative skills for as long as 12 hours [21].
• After 30 min the p-deletion and critical flicker fusion scores were still impaired in the midazolam, but not in the propofol, group [22].
• Quetiapine, but not haloperidol, reduced subjective alertness and critical flicker fusion frequency [23].
• Critical flicker fusion was significantly increased in subjects on temazepam [24].

Gene context of Flicker Fusion

• METHODS: Loperamide hydrochloride (2 mg) was administered orally to 26 subjects and the critical flicker-fusion frequency threshold (CFF) values were measured every 30 min separately by portable instrument [25].
• Flicker fusion thresholds in Best macular dystrophy [26].
• Flicker-fusion frequency was determined to be approximately 10 Hz lower in albino animals, which is due to prolonged b-waves in these ERGs [27].
• The tested dose of haloperidol induced a distinct rise in serum prolactin and sedation, but had no effects on the pharmaco-EEG or on the critical flicker-fusion frequency [28].
• Growth hormone secretion was assessed by quantifying serum growth hormone concentrations; sedation was assessed by both visual analogue scales (VAS) and by a visual psychomotor response meter, measuring critical flicker fusion (CFF) [29].

Analytical, diagnostic and therapeutic context of Flicker Fusion

• Bartholomews and the Royal London School of Medicine and Dentistry. DESIGN: Subjects were tested for central and peripheral fatigue using a visual analogue scale, flicker fusion frequency, grip strength, reaction time and wrist ergometry [30].
• The effects of oral triazolam 0.25 mg and zopiclone 7.5 mg in 7 supine volunteers were compared by means of quantitative measurements of the EEG, saccadic eye movements, visual analogue scale (VAS) for alertness, critical flicker fusion frequency (CFF) and the Maddox wing [31].

References