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Chemical Compound Review

Ektebin     2-propylpyridine-4- carbothioamide

Synonyms: Tebeform, Trevintix, Tuberex, Peteha, Protionamid, ...
 
 
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Disease relevance of prothionamide

 

Psychiatry related information on prothionamide

 

High impact information on prothionamide

 

Analytical, diagnostic and therapeutic context of prothionamide

  • Simple, rapid and sensitive determination of protionamide in human serum by high-performance liquid chromatography [11].
  • Whereas there is no direct proof that "M. lufu" is the best suitable model for drug evaluation against M. leprae, there is, however, nothing in the presented results which is against this model, especially as the actions of DDS and PTH or RAMP is concerned [12].

References

  1. Mechanism of thioamide drug action against tuberculosis and leprosy. Wang, F., Langley, R., Gulten, G., Dover, L.G., Besra, G.S., Jacobs, W.R., Sacchettini, J.C. J. Exp. Med. (2007) [Pubmed]
  2. A comparison of the blood levels and urinary excretion of ethionamide and prothionamide in man. Jenner, P.J., Ellard, G.A., Gruer, P.J., Aber, V.R. J. Antimicrob. Chemother. (1984) [Pubmed]
  3. Sensitivity to capreomycin and prothionamide in strains of Mycobacterium, Nocardia, Rhodococcus, and related taxa for taxonomical purposes. Ridell, M. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectiousdiseases, para... (1983) [Pubmed]
  4. Joint chemotherapy trials in lepromatous leprosy conducted in Thailand, the Philippines, and Korea. Cellona, R.V., Fajardo, T.T., Kim, D.I., Hah, Y.M., Ramasoota, T., Sampattavanich, S., Carrillo, M.P., Abalos, R.M., dela Cruz, E.C., Ito, T. Int. J. Lepr. Other Mycobact. Dis. (1990) [Pubmed]
  5. Ethionamide, prothionamide and thiacetazone self-administration. Studies of patient compliance using isoniazid-marked formulations. Stanley, J.N., Pearson, J.M., Ellard, G.A. Leprosy review. (1986) [Pubmed]
  6. High-performance liquid chromatographic determination of ethionamide and prothionamide in body fluids. Jenner, P.J., Ellard, G.A. J. Chromatogr. (1981) [Pubmed]
  7. Determination of prothionamide and its sulphoxide metabolite in physiological fluids by quantitative thin-layer chromatography. Rossi, M., Rübamen, K. J. Chromatogr. (1977) [Pubmed]
  8. Activity of ofloxacin against Mycobacterium leprae in the mouse. Grosset, J.H., Guelpa-Lauras, C.C., Perani, E.G., Beoletto, C. Int. J. Lepr. Other Mycobact. Dis. (1988) [Pubmed]
  9. Feasibility of multidrug therapy (MDT) in Hansen's disease in an urban population--Curupaiti State Hospital, Rio de Janeiro, Brazil. Andrade, V.L., Marques, A.B., da Cunha, L.H., Avelleira, J.R. Int. J. Lepr. Other Mycobact. Dis. (1987) [Pubmed]
  10. A study of drug interactions in leprosy--1. Effect of simultaneous administration of prothionamide on metabolic disposition of rifampicin and dapsone. Mathur, A., Venkatesan, K., Girdhar, B.K., Bharadwaj, V.P., Girdhar, A., Bagga, A.K. Leprosy review. (1986) [Pubmed]
  11. Simple, rapid and sensitive determination of protionamide in human serum by high-performance liquid chromatography. Bartels, H., Bartels, R. J. Chromatogr. B Biomed. Sci. Appl. (1998) [Pubmed]
  12. Bacterial growth kinetics of "M. lufu" in the presence and absence of various drugs alone and in combination. A model for the development of combined chemotherapy against M. leprae? Seydel, J.K., Wempe, E.G. Int. J. Lepr. Other Mycobact. Dis. (1982) [Pubmed]
 
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