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MeSH Review

Drug Evaluation

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Disease relevance of Drug Evaluation


High impact information on Drug Evaluation


Chemical compound and disease context of Drug Evaluation

  • Twenty-five compounds structurally related to clofazimine were tested for their ability to inhibit the growth of Mycobacterium leprae using the kinetic method of drug evaluation in the mouse foot pad model of leprosy [11].

Anatomical context of Drug Evaluation


Associations of Drug Evaluation with chemical compounds


Gene context of Drug Evaluation

  • Drug effects on afterdischarge and seizure threshold in lissencephalic ferrets: an epilepsy model for drug evaluation [20].
  • CFA-based analyses appear to be suitable for psychotropic drug evaluation when more refined and data-related information on drug efficacy profiles are required [21].
  • On behalf of the Nova Scotia Seniors' Pharmacare Program, the Drug Evaluation Alliance of Nova Scotia developed a multicomponent intervention plan to facilitate the removal of chlorpropamide as an insured benefit [22].
  • Materials and METHODS: We used MTT in combination with other in vitro drug evaluation assays to screen potential MDR modifiers from a series of naturally occurring Bisbenzylisoquinoline Alkaloids (BBIs) that were isolated from natural plants [23].
  • New drug evaluations amiloride (Midamor, Merck, Sharp and Dohme) [24].

Analytical, diagnostic and therapeutic context of Drug Evaluation


  1. The acute effect of haloperidol and apomorphine on the severity of stuttering. Burns, D., Brady, J.P., Kuruvilla, K. Biol. Psychiatry (1978) [Pubmed]
  2. Prostate-specific antigen: A surrogate endpoint for screening new agents against prostate cancer? Schröder, F.H., Kranse, R., Barbet, N., Hop, W.C., Kandra, A., Lassus, M. Prostate (2000) [Pubmed]
  3. Clinical predictors of implantable cardioverter-defibrillator shocks (results of the CASCADE trial). Cardiac Arrest in Seattle, Conventional versus Amiodarone Drug Evaluation. Dolack, G.L. Am. J. Cardiol. (1994) [Pubmed]
  4. Use of digoxigenin-labelled probes for the quantitation of HBV-DNA in antiviral drug evaluation. Ying, C., Van Pelt, J., Yap, S.H., De Clercq, E., Neyts, J. J. Virol. Methods (1999) [Pubmed]
  5. Amiodarone: clinical trials. Naccarelli, G.V., Wolbrette, D.L., Patel, H.M., Luck, J.C. Curr. Opin. Cardiol. (2000) [Pubmed]
  6. FDA Arthritis Advisory Committee Meeting: juvenile rheumatoid arthritis drug evaluation guidelines; over-the-counter naproxen? Paulus, H.E. Arthritis Rheum. (1994) [Pubmed]
  7. Epinephrine infusions during antiarrhythmic drug evaluations: toward a better understanding of drug activity. DiMarco, J.P. J. Am. Coll. Cardiol. (1992) [Pubmed]
  8. Olsalazine versus placebo in the treatment of mild to moderate ulcerative colitis: a randomised double blind trial. Feurle, G.E., Theuer, D., Velasco, S., Barry, B.A., Wördehoff, D., Sommer, A., Jantschek, G., Kruis, W. Gut (1989) [Pubmed]
  9. Paradoxical bronchospasm associated with the use of inhaled beta agonists. Nicklas, R.A. J. Allergy Clin. Immunol. (1990) [Pubmed]
  10. A randomized double blind cross-over trial of nifedipine in the treatment of primary Raynaud's phenomenon. Corbin, D.O., Wood, D.A., Macintyre, C.C., Housley, E. Eur. Heart J. (1986) [Pubmed]
  11. Activity of phenazine analogs against Mycobacterium leprae infections in mice. Van Landingham, R.M., Walker, L.L., O'Sullivan, J.F., Shinnick, T.M. Int. J. Lepr. Other Mycobact. Dis. (1993) [Pubmed]
  12. Human blood platelet as research tool in neuropsychopharmacology. Bongioanni, P., Dadone, F., Donato, M. J. Neural Transm. Suppl. (1991) [Pubmed]
  13. In vitro and in vivo characterizations of tetrandrine on the reversal of P-glycoprotein-mediated drug resistance to paclitaxel. Zhu, X., Sui, M., Fan, W. Anticancer Res. (2005) [Pubmed]
  14. Bilateral surgical removal of impacted mandibular third molar teeth as a model for drug evaluation: a test with oxyphenbutazone (Tanderil). Album, B., Olsen, I., Lokken, P. International journal of oral surgery. (1977) [Pubmed]
  15. Effectiveness of intermediate-term use of secobarbital. Kales, A., Hauri, P., Bixler, E.O., Silberfarb, P. Clin. Pharmacol. Ther. (1976) [Pubmed]
  16. Effectiveness of hypnotic drugs with prolonged use: flurazepam and pentobarbital. Kales, A., Kales, J.D., Bixler, E.O., Scharf, M.B. Clin. Pharmacol. Ther. (1975) [Pubmed]
  17. Clinical pharmacokinetics of anthelmintic drugs. Edwards, G., Breckenridge, A.M. Clinical pharmacokinetics. (1988) [Pubmed]
  18. Ex vivo cytotoxic drug evaluation by DiSC assay to expedite identification of clinical targets: results with 8-chloro-cAMP. Bosanquet, A.G., Burlton, A.R., Bell, P.B., Harris, A.L. Br. J. Cancer (1997) [Pubmed]
  19. Anticancer drug evaluation: continuing progress from existing methodology. ten Bokkel Huinink, W. Eur. J. Cancer (1997) [Pubmed]
  20. Drug effects on afterdischarge and seizure threshold in lissencephalic ferrets: an epilepsy model for drug evaluation. Majkowski, J. Epilepsia (1983) [Pubmed]
  21. Differential effects of high-dose amisulpride versus flupentixol on latent dimensions of depressive and negative symptomatology in acute schizophrenia: an evaluation using confirmatory factor analysis. Müller, M.J., Wetzel, H., Benkert, O. International clinical psychopharmacology. (2002) [Pubmed]
  22. The effect of deinsuring chlorpropamide on the prescribing of oral antihyperglycemics for Nova Scotia Seniors' Pharmacare beneficiaries. Sketris, I.S., Kephart, G.C., Frail, D.M., Skedgel, C., Allen, M.J. Pharmacotherapy (2004) [Pubmed]
  23. Screening and discovery of novel MDR modifiers from naturally occurring bisbenzylisoquinoline alkaloids. Fu, L.W., Deng, Z.A., Pan, Q.C., Fan, W. Anticancer Res. (2001) [Pubmed]
  24. New drug evaluations amiloride (Midamor, Merck, Sharp and Dohme). Macfie, H.L., Colvin, C.L., Anderson, P.O. Drug intelligence & clinical pharmacy. (1981) [Pubmed]
  25. Sequential single-photon emission computed tomography myocardial perfusion imaging. Shaw, L.J., Berman, D.S. Am. J. Cardiol. (2005) [Pubmed]
  26. Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat. Micheletti, G., Vergnes, M., Marescaux, C., Reis, J., Depaulis, A., Rumbach, L., Warter, J.M. Arzneimittel-Forschung. (1985) [Pubmed]
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