Chemical Compound Review:
Ethinamat (1-ethynylcyclohexyl) carbamate
Synonyms:
Etinamate, Etinamato, Valamin, Valmidate, Volamin, ...
- Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis. Frénois, F., Engohang-Ndong, J., Locht, C., Baulard, A.R., Villeret, V. Mol. Cell (2004)
- Ethionamide-induced goitrous hypothyroidism. Drucker, D., Eggo, M.C., Salit, I.E., Burrow, G.N. Ann. Intern. Med. (1984)
- Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis. DeBarber, A.E., Mdluli, K., Bosman, M., Bekker, L.G., Barry, C.E. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Clinical pharmacokinetics of the antituberculosis drugs. Holdiness, M.R. Clinical pharmacokinetics. (1984)
- Cerebrospinal fluid concentrations of ethionamide in children with tuberculous meningitis. Donald, P.R., Seifart, H.I. J. Pediatr. (1989)
- inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Banerjee, A., Dubnau, E., Quemard, A., Balasubramanian, V., Um, K.S., Wilson, T., Collins, D., de Lisle, G., Jacobs, W.R. Science (1994)
- Mechanism of thioamide drug action against tuberculosis and leprosy. Wang, F., Langley, R., Gulten, G., Dover, L.G., Besra, G.S., Jacobs, W.R., Sacchettini, J.C. J. Exp. Med. (2007)
- Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis. Quémard, A., Sacchettini, J.C., Dessen, A., Vilcheze, C., Bittman, R., Jacobs, W.R., Blanchard, J.S. Biochemistry (1995)
- Metabolism of Thioamides by Ralstonia pickettii TA. Dodge, A.G., Richman, J.E., Johnson, G., Wackett, L.P. Appl. Environ. Microbiol. (2006)
- Oxidative activation of thiacetazone by the Mycobacterium tuberculosis flavin monooxygenase EtaA and human FMO1 and FMO3. Qian, L., Ortiz de Montellano, P.R. Chem. Res. Toxicol. (2006)
- Resistance of multidrug-resistant strains of Mycobacterium tuberculosis from the Archangel oblast, Russia, to second-line anti-tuberculosis drugs. Toungoussova, O.S., Mariandyshev, A.O., Bjune, G., Caugant, D.A., Sandven, P. Eur. J. Clin. Microbiol. Infect. Dis. (2005)
- Efficacy and safety of sparfloxacin in combination with kanamycin and ethionamide in multidrug-resistant pulmonary tuberculosis patients: preliminary results. Singla, R., Gupta, S., Gupta, R., Arora, V.K. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. (2001)
- The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase. Vannelli, T.A., Dykman, A., Ortiz de Montellano, P.R. J. Biol. Chem. (2002)
- Crystal structure of the TetR/CamR family repressor Mycobacterium tuberculosis EthR implicated in ethionamide resistance. Dover, L.G., Corsino, P.E., Daniels, I.R., Cocklin, S.L., Tatituri, V., Besra, G.S., Fütterer, K. J. Mol. Biol. (2004)
- Pharmacokinetics of ethionamide administered under fasting conditions or with orange juice, food, or antacids. Auclair, B., Nix, D.E., Adam, R.D., James, G.T., Peloquin, C.A. Antimicrob. Agents Chemother. (2001)
- Effect of inhibitors of alpha-naphthylisothiocyanate-induced hepatotoxicity on the in vitro metabolism of alpha-naphthylisothiocyanate. Traiger, G.J., Vyas, K.P., Hanzlik, R.P. Chem. Biol. Interact. (1985)
- Mutagenic activity of antileprosy drugs and their derivatives. Peters, J.H., Gordon, G.R., Murray, J.F., Simmon, V.F. Int. J. Lepr. Other Mycobact. Dis. (1983)
- A comparison of the blood levels and urinary excretion of ethionamide and prothionamide in man. Jenner, P.J., Ellard, G.A., Gruer, P.J., Aber, V.R. J. Antimicrob. Chemother. (1984)
- Cycloserine plus ethionamide plus pyrazinamide in the treatment of patients excreting isoniazid-resistant tubercle bacilli following previous chemotherapy. Ramakrishnan, C.V., Parthasarathy, R., Sambamoorthy, S., Somasundaram, P.R., Subbammal, S. Indian J. Med. Res. (1976)
- Treatment of multibacillary leprosy with a regimen of 13 weeks duration. Pattyn, S.R., Groenen, G., Janssens, L., Kuykens, L., Mputu, L.B. Leprosy review. (1992)
- Inhibitory effect of antituberculosis drugs on human cytochrome P450-mediated activities. Nishimura, Y., Kurata, N., Sakurai, E., Yasuhara, H. J. Pharmacol. Sci. (2004)
- Neurological manifestations and toxicities of the antituberculosis drugs. A review. Holdiness, M.R. Medical toxicology. (1987)
- ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates. Morlock, G.P., Metchock, B., Sikes, D., Crawford, J.T., Cooksey, R.C. Antimicrob. Agents Chemother. (2003)
- NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis. Miesel, L., Weisbrod, T.R., Marcinkeviciene, J.A., Bittman, R., Jacobs, W.R. J. Bacteriol. (1998)
- Exploring drug action on Mycobacterium tuberculosis using affymetrix oligonucleotide genechips. Fu, L.M. Tuberculosis (Edinburgh, Scotland) (2006)
- Improved high-performance liquid chromatographic assay for the determination of ethionamide in serum. Peloquin, C.A., James, G.T., McCarthy, E. J. Chromatogr. (1991)
- High-performance liquid chromatographic-tandem mass spectrometric method for the determination of ethionamide in human plasma, bronchoalveolar lavage fluid and alveolar cells. Conte, J.E., Wang, G., Lin, E.T., Zurlinden, E. J. Chromatogr. B Biomed. Sci. Appl. (2001)
- Polymeric colloidal systems containing ethionamide: preparation and physico-chemical characterization. Lopes, E., Pohlmann, A.R., Bassani, V., Guterres, S.S. Die Pharmazie. (2000)