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Chemical Compound Review

Ambasilida     (4-aminophenyl)-(7-benzyl- 3,7...

Synonyms: Ambasilide, Ambasilidum, SureCN427931, AG-K-19567, KST-1A8759, ...
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Disease relevance of Ambasilide


High impact information on Ambasilide

  • This study evaluated effects of ambasilide, quinidine, flecainide and verapamil on I(Kur.d) in isolated canine atrial myocytes [3].
  • By comparison, ambasilide inhibited HERG channels with lower potency (IC(50) 3.6 microM), in a voltage- and time-dependent but frequency-independent manner (0.03-1 Hz) [4].
  • The 50% inhibitory concentration of ambasilide averaged 23 +/- 2 microM and 34 +/- 3 microM for I(to) and I(Kur) respectively [5].
  • Ambasilide (1 microM) prolonged the action potential (APD) at 20, 50 and 90% repolarization by 11.2 +/- 4.3, 13.8 +/- 3.9 and 13.6 +/- 3.7%, respectively, compared to control (n = 10) [6].
  • The block of Ik by ambasilide was compared to that by E-4031 (5 microM), a putative selective blocker of that fast, inwardly rectifying component of Ik identified in guinea pig ventricle [6].

Biological context of Ambasilide

  • The antiarrhythmic effect of ambasilide persisted when heart rate was kept constant by atrial pacing [2].
  • Ambasilide decreased heart rate and blood pressure and prolonged QRS duration (26%, p < 0.05), QTc (17%, p < 0.0001), and JTc (16%, p < 0.005) [2].
  • These data suggest that ambasilide, in addition to its Class III antiarrhythmic action, which is presumably due to its inhibitory effect on the delayed rectifier potassium current, possesses I/B type antiarrhythmic properties as a result of the inhibition of the fast sodium channels at high frequency rate with relatively fast kinetics [7].

Anatomical context of Ambasilide

  • In Purkinje fibers, the prolonging effect of ambasilide on APD-80 was more pronounced at lower stimulation frequency, whereas APD-20 shortened at all stimulation frequencies [8].
  • Electrophysiologic effects of ambasilide (LU 47110), a novel class III antiarrhythmic agent, on the properties of isolated rabbit and canine cardiac muscle [8].

Associations of Ambasilide with other chemical compounds


Analytical, diagnostic and therapeutic context of Ambasilide


  1. Class III antiarrhythmic drug action in experimental atrial fibrillation. Differences in reverse use dependence and effectiveness between d-sotalol and the new antiarrhythmic drug ambasilide. Wang, J., Feng, J., Nattel, S. Circulation (1994) [Pubmed]
  2. Effects of the potassium channel blocking agent ambasilide on ventricular arrhythmias induced by acute myocardial ischemia and sympathetic activation. Stramba-Badiale, M., Pessano, P., Kirchengast, M., Schwartz, P.J. Am. Heart J. (1995) [Pubmed]
  3. Effects of ambasilide, quinidine, flecainide and verapamil on ultra-rapid delayed rectifier potassium currents in canine atrial myocytes. Yue, L., Feng, J.L., Wang, Z., Nattel, S. Cardiovasc. Res. (2000) [Pubmed]
  4. Comparative effects of azimilide and ambasilide on the human ether-a-go-go-related gene (HERG) potassium channel. Walker, B.D., Singleton, C.B., Tie, H., Bursill, J.A., Wyse, K.R., Valenzuela, S.M., Breit, S.N., Campbell, T.J. Cardiovasc. Res. (2000) [Pubmed]
  5. Effects of class III antiarrhythmic drugs on transient outward and ultra-rapid delayed rectifier currents in human atrial myocytes. Feng, J., Wang, Z., Li, G.R., Nattel, S. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  6. Effect of ambasilide, a new class III agent, on plateau currents in isolated guinea pig ventricular myocytes: block of delayed outward potassium current. Zhang, Z.H., Follmer, C.H., Sarma, J.S., Chen, F., Singh, B.N. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  7. Analysis of the electrophysiological effects of ambasilide, a new antiarrhythmic agent, in canine isolated ventricular muscle and purkinje fibers. Baláti, B., Iost, N., Simon, J., Varró, A., Papp, J.G. Gen. Pharmacol. (2000) [Pubmed]
  8. Electrophysiologic effects of ambasilide (LU 47110), a novel class III antiarrhythmic agent, on the properties of isolated rabbit and canine cardiac muscle. Takanaka, C., Sarma, J.S., Singh, B.N. J. Cardiovasc. Pharmacol. (1992) [Pubmed]
  9. Differential effect of beta-adrenergic stimulation on the frequency-dependent electrophysiologic actions of the new class III antiarrhythmics dofetilide, ambasilide, and chromanol 293B. Schreieck, J., Wang, Y., Gjini, V., Korth, M., Zrenner, B., Schömig, A., Schmitt, C. J. Cardiovasc. Electrophysiol. (1997) [Pubmed]
  10. Rate-independent effects of the new class III antiarrhythmic agent ambasilide on transmembrane action potentials in human ventricular endomyocardium. Weyerbrock, S., Schreieck, J., Karch, M., Overbeck, M., Meisner, H., Kemkes, B., Schömig, A., Schmitt, C. J. Cardiovasc. Pharmacol. (1997) [Pubmed]
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