Disease relevance of Pericarditis

• Markedly elevated creatinine phosphokinase, cotton wool spots, and pericarditis in a patient with leptospirosis [1].
• Pericardial effusion was more common in anterior AMI (p less than .02) and in patients with heart failure (p less than .05) but it was not significantly associated with early pericarditis, peak creatine kinase-MB, the level of anticoagulation, or mortality [2].
• METHODS AND RESULTS: The effects of moricizine (2 mg/kg IV) on induced atrial flutter were studied 2 to 4 days after the creation of sterile pericarditis in 11 dogs [3].
• These collections of macrophages were associated with chronic inflammatory cells and foci of fibrosis with resultant adhesive pericarditis, focal myocardial fibrosis similar to the fibrosis of idiopathic cardiomyopathy, and valvular fibrosis with deformity grossly resembling the valvular lesions of chronic rheumatic heart disease [4].
• We found increased chronic CB3-induced myocarditis (14.1 to 43.1%, P < 0.001); pericarditis (1.5 to 7.6%, P < 0.001); fibrosis (9.7 to 27.4%, P < 0.05); and the profibrotic cytokines transforming growth factor-beta(1), IL-1 beta, and IL-4 in the hearts of IFN-gamma-deficient mice [5].

High impact information on Pericarditis

• Among 96 persons, limb-lead RST deviations occurred in all 48 with pericarditis, but only 27 with early repolarization [6].
• JAMA patient page. Pericarditis [7].
• Captopril pericarditis [8].
• Among patients who did not have open drainage on admission, 2 (3%) of 76 given prednisolone compared with 10 (14%) of 74 given placebo died of pericarditis (p less than 0.05), 6 (8%) and 9 (12%) respectively required pericardiectomy, 7 (9%) and 17 (23%) repeat pericardiocentesis (p less than 0.05), and 3 (4%) and 7 (9%) open surgical drainage [9].
• Letter: Inflammatory bowel disease and pericarditis [10].

Chemical compound and disease context of Pericarditis

• In an additional 6 dogs with sterile pericarditis and inducible AF, ambasilide prevented AF induction in all 6 [11].
• Recurrent pericarditis. Relief with colchicine [12].
• Circus movement atrial flutter in the canine sterile pericarditis model. Differential effects of procainamide on the components of the reentrant pathway [13].
• Indomethacin appears to be effective in the treatment of the pericarditis associated with dialysis and precludes the need for invasive procedures [14].
• The dose and duration of steroid treatment are critical factors in preventing recurrent pericarditis [15].

Biological context of Pericarditis

• As in other reported cases histology revealed a fibrinous mononuclear pericarditis and the pericardial fluid was a serosanguinous inflammatory exudate with a high LDH level and normal glucose concentration [16].
• The association of pericarditis with practolol but not with other beta-blockers, the association of captopril and other angiotensin-converting enzymes with cough, and the association of terfenadine with heart rate and rhythm disorders could be identified by mining the WHO database [17].
• Five strains of an unusual Gram-negative, catalase-positive, oxidase-positive, coccobacillus-shaped bacterium isolated from the lungs and heart of pigs with pneumonia and pericarditis were characterized by phenotypic and molecular genetic methods [18].

Anatomical context of Pericarditis

• Although neither one is specific, the light and electron microscopic lesions caused by x-radiation (myocardial capillary damage, pericarditis) were easily distinguished from those caused by adriamycin (myocyte damage) [19].
• Occult purulent pericarditis detected by indium-111 leukocyte imaging [20].
• The incidence was increased in younger patients, in those with a history of prednisone use in the past, in patients with a past history of pericarditis, those with aortic valve replacement, and in patients who received enflurane or halothane anesthesia [21].
• TCR V beta selection from a DRB1*401*0101 patient with rheumatoid arthritis complicated by a CD8+ T cell infiltrated rheumatoid pericarditis [22].
• Potential adverse effects of mediastinal irradiation are numerous and can include coronary artery disease, pericarditis, cardiomyopathy, valvular disease and conduction abnormalities [23].

Gene context of Pericarditis

• Idiopathic recurrent acute pericarditis: familial Mediterranean fever mutations and disease evolution in a large cohort of Caucasian patients [24].
• With a cutoff value for CEA level of 5 ng/mL, sensitivity was 75% and specificity 100% in the diagnosis of malignant pericarditis [25].
• A case of rheumatoid pericarditis that developed into cardiac tamponade without deterioration of rheumatoid arthritis is described [26].
• IL-6 may be associated with progression or maintenance of rheumatoid pericarditis [26].
• The pericarditis patients were slightly older, had significantly shorter disease duration, had significantly increased levels of orosomucoid and haptoglobin, and were significantly more often antinuclear-antibody positive than those without pericarditis [27].

Analytical, diagnostic and therapeutic context of Pericarditis

• Radiation therapy, pericarditis with restrictive cardiomyopathy, high RVEDP, NYHA class IV status, renal dysfunction, and diuretic use adversely influenced outcome in patients undergoing pericardiectomy [28].
• Indomethacin treatment of pericarditis in chronic hemodialysis patients [14].
• METHODS: Sterile pericarditis was created in 20 dogs randomly assigned to two groups: a control group (10 dogs) and an atorvastatin treatment group (10 dogs) [29].
• Scintigraphy has demonstrated gallium-67 accumulation within the heart in pericarditis and cardiomyopathies of various kinds [30].
• To determine the impact of indomethacin on the course of uremic pericarditis we performed a prospective, double blind study in which 24 patients with endstage chronic renal failure and pericarditis randomly received indomethacin, 25 mg four times daily, (11 patients) or a placebo (13 patients) for a 3-week period [31].

References