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Chemical Compound Review:

Cyclotropium [(1R,5R)-8-methyl-8-propan-2- yl-8...

Synonyms: AG-K-36068, KST-1A8855, CTK5F4372, AR-1A1321, AC1L2H8V, ...

This record was replaced with 72011.

Heuer, H. et al., Stacher, G. et al., Liebmann, B. et al., Glube, N. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 2-cyclopentyl-2-phenyl-acetic acid [(1R,5R)-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]oct-3-yl] ester

Therefore, the comparative effects of atropine (A) and ciclotropium bromide (C) on heart rate (HR) and electrical stimulation thresholds for repetitive atrial extrasystoles (RET) and fibrillation (AFT) were established in 14 mongrel dogs (BW 20-30 kg, artificial ventilation, piritramide-N2O anaesthesia) [1].

Psychiatry related information on 2-cyclopentyl-2-phenyl-acetic acid [(1R,5R)-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]oct-3-yl] ester

This study investigated the effects of single oral doses of 60 mg cyclotropium bromide, 60 mg hyoscine N-butylbromide and placebo on gastric emptying and on antral motor activity [2].

High impact information on 2-cyclopentyl-2-phenyl-acetic acid [(1R,5R)-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]oct-3-yl] ester

In conclusion, cyclotropium bromide markedly inhibits gastric emptying and reduces antral contraction amplitude [2].
Cyclotropium bromide, a new antimuscarinic agent, inhibits gastrointestinal motility in animals at lower doses than those required to inhibit gastric acid secretion and salivation [2].
The quaternary ammonium compounds ciclotropium bromide and ipratropium bromide were strong inhibitors with IC50 values of 30 muM and 95 muM, respectively [3].
The relevance of this metabolic route for ciclotropium bromide (HIT-PCE, CAS 85166-20-7) including its stereochemical aspects was studied in a preliminary pharmacokinetic study [4].
Effects of the new vagolytic compound ciclotropium bromide on heart rate and atrial vulnerability [1].

Analytical, diagnostic and therapeutic context of 2-cyclopentyl-2-phenyl-acetic acid [(1R,5R)-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]oct-3-yl] ester

The effects of the new vagolytic compound alpha-phenylcyclopentane-acetic acid-N-isopropyl-nortropine ester methobromide (ciclotropium bromide) on heart rate and atrial vulnerability were assessed in the animal experiment [1].

References

Effects of the new vagolytic compound ciclotropium bromide on heart rate and atrial vulnerability. Heuer, H., Frenking, B., Thale, J., Gülker, H., Müller, U.S., Bender, F. Arzneimittel-Forschung. (1986) [Pubmed]
Effects of oral cyclotropium bromide, hyoscine N-butylbromide and placebo on gastric emptying and antral motor activity in healthy man. Stacher, G., Bergmann, H., Havlik, E., Schmierer, G., Schneider, C. Gut (1984) [Pubmed]
OCTN2-Mediated Carnitine Uptake in a Newly Discovered Human Proximal Tubule Cell Line (Caki-1). Glube, N., Closs, E., Langguth, P. Mol. Pharm. (2007) [Pubmed]
Studies on the metabolic clearance of ciclotropium to alpha-phenylciclopentylacetic acid using a new enantiospecific metabolite assay. Liebmann, B., Mayer, S., Mutschler, E., Spahn-Langguth, H. Arzneimittel-Forschung. (1992) [Pubmed]

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