Disease relevance of Atrial Premature Complexes

• Mean atrial premature complex (APC) density per 1,000 beats (0.9 v 0.7 for patients with MVP and control subjects, respectively) and mean ventricular premature complex (VPC) density per 1,000 total beats (1.2 v 1.5) did not differ between groups [1].
• Bradycardia, coupled beats, ectopic ventricular foci, premature atrial beats and prolonged PR interval were found [2].
• Echocardiography documented fetal premature atrial contractions after maternal hydralazine treatment for hypertension [3].
• Patients receiving Optison had more premature atrial contractions ( P < .05) but there was no difference in the incidence of ventricular tachycardia, supraventricular tachycardia, or vagally mediated episodes [4].
• Pilsicainide (four patients) or flecainide (one patient) were administered orally for the treatment of symptomatic paroxysmal atrial fibrillation or premature atrial contractions [5].

High impact information on Atrial Premature Complexes

• Frequent premature atrial beats were abolished or reduced by greater than 75% in each of 2 patients by acebutolol and not in a patient by saline [6].
• The class III antiarrhythmic drugs dofetilide and sotalol prevent AF induction by atrial premature complexes at doses that fail to terminate AF [7].
• Similar heart rate response is present after atrial premature complexes. "Atrial" turbulence slope (TSA) moderately correlates with "ventricular" turbulence slope (TSV) [8].
• Spontaneous or orciprenaline-induced atrial premature complexes (APCs) were mapped [9].
• She was treated with oral digoxin for the remainder of her pregnancy with subsequent conversion of the tachycardic triplet to normal sinus rhythm with occasional premature atrial beats [10].

Chemical compound and disease context of Atrial Premature Complexes

• Fetal premature atrial contractions associated with hydralazine [3].
• Atropine administration produced a significant increase in the percentage of the sinus cycle length at which premature atrial contractions penetrated and reset the sinus node [11].
• Sixteen patients had atrial extrasystoles, four with albuterol, one with placebo, and 11 with both drugs [12].
• A minor, nonsignificant reduction in atrial premature complexes was seen in patients who received enalapril [13].
• A 3-month Diagnostic Phase with conventional pacing identified a Substrate Group (>70% of AF episodes with <2 premature atrial contractions [PACs] before AF onset) and a Trigger Group (< or =70% of AF episodes with <2 PACs before AF onset) [14].

Biological context of Atrial Premature Complexes

• Six patients in the halothane group (n = 14) and nine patients in the enflurane group (n = 14) developed premature atrial contractions and nodal rhythm, while nine patients in the halothane group and five in the enflurane group developed a fall in systolic blood pressure of more than 20 mmHg (2.7 kPa) [15].

Gene context of Atrial Premature Complexes

• Although the number of premature atrial contractions was significantly less during BAP than RAP (p<0.05), there were no significant differences of AF episodes between the two [16].

References