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Gene Review

MUC5AC  -  mucin 5AC, oligomeric mucus/gel-forming

Homo sapiens

Synonyms: Gastric mucin, LeB, Lewis B blood group antigen, MUC-5AC, MUC5, ...
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Disease relevance of MUC5AC


Psychiatry related information on MUC5AC

  • TBM plays a useful role in the differentiation and management of various other disorders, including depression, behavioral disturbances and dementias [6].

High impact information on MUC5AC

  • CD34+ human marrow cells not expressing T cell-, B cell-, and myeloid cell-associated antigens (TBM-) were cloned by two-color cell sorting into culture wells containing irradiated marrow stromal cells [7].
  • Results in cultured airway epithelial cells showed that samples of asthmatic fluid stimulated mucin (MUC5AC) synthesis severalfold more potently than non-asthmatic fluid [8].
  • Both patient antisera containing alpha TBM-Ab were also highly reactive with R3M-1, the 48,000-mol-wt rabbit glycoprotein antigen of experimental alpha TBM disease [9].
  • Using a monoclonal anti-tubular basement membrane antibody (alpha TBM-Ab) affinity column, we isolated from collagenase-solubilized human renal tissue (HSRTA) a predominantly 48,000-mol-wt moiety (H3M-1) which is selectively recognized by antisera from two patients with alpha TBM-Ab-associated interstitial nephritis (alpha TBM disease) [9].
  • RESULTS: In the 22 RVAs, we found an overexpression of MUC2 and an aberrant expression of MUC5AC [10].

Chemical compound and disease context of MUC5AC


Biological context of MUC5AC

  • However, the mechanisms by which the interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha induce MUC5AC gene expression in normal nasal epithelial cells, and the signal molecules involved, especially in the downstream signaling of mitogen-activated protein (MAP) kinases, remain unclear [16].
  • Both cases of MUC6 positivity and 1/5 cases of MUC5AC positivity were confined to the ulcer associated cell lineage [17].
  • Intense expression of the MUC5AC gene, suggesting a gastric surface cell phenotype, was demonstrated in 18/21 tumours (86%) [18].
  • Analysis of cells isolated by microdissection showed stepwise upregulation of MUC1 and MUC5AC in the development of high-grade PanIN to IDC [19].
  • In this study, the organization of MUC5AC has been entirely elucidated showing extensive similarity to the other chromosome 11p15 MUC genes, particularly MUC5B, and providing additional arguments for common evolution from a single ancestral gene [20].

Anatomical context of MUC5AC


Associations of MUC5AC with chemical compounds


Physical interactions of MUC5AC


Regulatory relationships of MUC5AC


Other interactions of MUC5AC


Analytical, diagnostic and therapeutic context of MUC5AC


  1. In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues. Balagué, C., Audié, J.P., Porchet, N., Real, F.X. Gastroenterology (1995) [Pubmed]
  2. Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas. Kim, G.E., Bae, H.I., Park, H.U., Kuan, S.F., Crawley, S.C., Ho, J.J., Kim, Y.S. Gastroenterology (2002) [Pubmed]
  3. MUC5AC, a Gel-Forming Mucin Accumulating in Gallstone Disease, Is Overproduced via an Epidermal Growth Factor Receptor Pathway in the Human Gallbladder. Finzi, L., Barbu, V., Burgel, P.R., Mergey, M., Kirkwood, K.S., Wick, E.C., Scoazec, J.Y., Peschaud, F., Paye, F., Nadel, J.A., Housset, C. Am. J. Pathol. (2006) [Pubmed]
  4. Mucin gene expression in intestinal epithelial cells in Crohn's disease. Buisine, M.P., Desreumaux, P., Leteurtre, E., Copin, M.C., Colombel, J.F., Porchet, N., Aubert, J.P. Gut (2001) [Pubmed]
  5. Differential expression of the chromosome 11 mucin genes in colorectal cancer. Sylvester, P.A., Myerscough, N., Warren, B.F., Carlstedt, I., Corfield, A.P., Durdey, P., Thomas, M.G. J. Pathol. (2001) [Pubmed]
  6. Technical and clinical aspects of topographic brain mapping. Hooshmand, H., Beckner, E., Radfar, F. Clinical EEG (electroencephalography). (1989) [Pubmed]
  7. Human hematopoietic precursors in long-term culture: single CD34+ cells that lack detectable T cell, B cell, and myeloid cell antigens produce multiple colony-forming cells when cultured with marrow stromal cells. Andrews, R.G., Singer, J.W., Bernstein, I.D. J. Exp. Med. (1990) [Pubmed]
  8. Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells. Longphre, M., Li, D., Gallup, M., Drori, E., Ordoñez, C.L., Redman, T., Wenzel, S., Bice, D.E., Fahy, J.V., Basbaum, C. J. Clin. Invest. (1999) [Pubmed]
  9. Isolation of the target antigen of human anti-tubular basement membrane antibody-associated interstitial nephritis. Clayman, M.D., Michaud, L., Brentjens, J., Andres, G.A., Kefalides, N.A., Neilson, E.G. J. Clin. Invest. (1986) [Pubmed]
  10. Aberrant expression of a human mucin gene (MUC5AC) in rectosigmoid villous adenoma. Buisine, M.P., Janin, A., Maunoury, V., Audié, J.P., Delescaut, M.P., Copin, M.C., Colombel, J.F., Degand, P., Aubert, J.P., Porchet, N. Gastroenterology (1996) [Pubmed]
  11. Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5). Meezaman, D., Charles, P., Daskal, E., Polymeropoulos, M.H., Martin, B.M., Rose, M.C. J. Biol. Chem. (1994) [Pubmed]
  12. Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway. Wang, B., Lim, D.J., Han, J., Kim, Y.S., Basbaum, C.B., Li, J.D. J. Biol. Chem. (2002) [Pubmed]
  13. Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas. Reis, C.A., David, L., Carvalho, F., Mandel, U., de Bolós, C., Mirgorodskaya, E., Clausen, H., Sobrinho-Simões, M. J. Histochem. Cytochem. (2000) [Pubmed]
  14. Gefitinib inhibits MUC5AC synthesis in mucin-secreting non-small cell lung cancer cells. Kitazaki, T., Soda, H., Doi, S., Nakano, H., Nakamura, Y., Kohno, S. Lung Cancer (2005) [Pubmed]
  15. Regulation of MUC5AC expression by NAD(P)H:quinone oxidoreductase 1. Zheng, S., Byrd, A.S., Fischer, B.M., Grover, A.R., Ghio, A.J., Voynow, J.A. Free Radic. Biol. Med. (2007) [Pubmed]
  16. Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. Song, K.S., Lee, W.J., Chung, K.C., Koo, J.S., Yang, E.J., Choi, J.Y., Yoon, J.H. J. Biol. Chem. (2003) [Pubmed]
  17. Mucin gene expression in the ileoanal reservoir is altered and may be relevant to the risk of inflammation and dysplasia. Sylvester, P.A., Walsh, M., Myerscough, N., Warren, B.F., Corfield, A.P., Thomas, M.G., Durdey, P. Gut (2002) [Pubmed]
  18. Mucin gene transcripts in benign and borderline mucinous tumours of the ovary: an in situ hybridization study. Boman, F., Buisine, M.P., Wacrenier, A., Querleu, D., Aubert, J.P., Porchet, N. J. Pathol. (2001) [Pubmed]
  19. Quantitative analysis of MUC1 and MUC5AC mRNA in pancreatic juice for preoperative diagnosis of pancreatic cancer. Ohuchida, K., Mizumoto, K., Yamada, D., Fujii, K., Ishikawa, N., Konomi, H., Nagai, E., Yamaguchi, K., Tsuneyoshi, M., Tanaka, M. Int. J. Cancer (2006) [Pubmed]
  20. Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region. Escande, F., Aubert, J.P., Porchet, N., Buisine, M.P. Biochem. J. (2001) [Pubmed]
  21. Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. Shao, M.X., Nadel, J.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  22. Permanent exposure of mucin-secreting HT-29 cells to benzyl-N-acetyl-alpha-D-galactosaminide induces abnormal O-glycosylation of mucins and inhibits constitutive and stimulated MUC5AC secretion. Hennebicq-Reig, S., Lesuffleur, T., Capon, C., De Bolos, C., Kim, I., Moreau, O., Richet, C., Hémon, B., Recchi, M.A., Maës, E., Aubert, J.P., Real, F.X., Zweibaum, A., Delannoy, P., Degand, P., Huet, G. Biochem. J. (1998) [Pubmed]
  23. Developmental expression of mucin genes in the human respiratory tract. Reid, C.J., Gould, S., Harris, A. Am. J. Respir. Cell Mol. Biol. (1997) [Pubmed]
  24. Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1. Perrais, M., Pigny, P., Copin, M.C., Aubert, J.P., Van Seuningen, I. J. Biol. Chem. (2002) [Pubmed]
  25. Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B. Keates, A.C., Nunes, D.P., Afdhal, N.H., Troxler, R.F., Offner, G.D. Biochem. J. (1997) [Pubmed]
  26. The trefoil protein TFF1 is bound to MUC5AC in human gastric mucosa. Ruchaud-Sparagano, M.H., Westley, B.R., May, F.E. Cell. Mol. Life Sci. (2004) [Pubmed]
  27. PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms. Hewson, C.A., Edbrooke, M.R., Johnston, S.L. J. Mol. Biol. (2004) [Pubmed]
  28. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. Shao, M.X., Nadel, J.A. J. Immunol. (2005) [Pubmed]
  29. Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells. Mata, M., Sarriá, B., Buenestado, A., Cortijo, J., Cerdá, M., Morcillo, E.J. Thorax (2005) [Pubmed]
  30. Downregulation of aquaporin 5 induced by vector-based short hairpin RNA and its effect on MUC5AC gene expression in human airway submucosal gland cells. Chen, Z., Zhu, R., Bai, L., Bai, C. Respiratory physiology & neurobiology. (2006) [Pubmed]
  31. IL-13 suppresses MUC5AC gene expression and mucin secretion in nasal epithelial cells. Kim, C.H., Song, K.S., Koo, J.S., Kim, H.U., Cho, J.Y., Kim, H.J., Yoon, J.H. Acta Otolaryngol. (2002) [Pubmed]
  32. cAMP-responding element-binding protein and c-Ets1 interact in the regulation of ATP-dependent MUC5AC gene expression. Song, K.S., Lee, T.J., Kim, K., Chung, K.C., Yoon, J.H. J. Biol. Chem. (2008) [Pubmed]
  33. Mucins as differentiation markers in bronchial epithelium. Squamous cell carcinoma and adenocarcinoma display similar expression patterns. López-Ferrer, A., Curull, V., Barranco, C., Garrido, M., Lloreta, J., Real, F.X., de Bolós C, n.u.l.l. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  34. Developmental mucin gene expression in the human respiratory tract. Buisine, M.P., Devisme, L., Copin, M.C., Durand-Réville, M., Gosselin, B., Aubert, J.P., Porchet, N. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  35. Barrett's esophagus is characterized by expression of gastric-type mucins (MUC5AC, MUC6) and TFF peptides (TFF1 and TFF2), but the risk of carcinoma development may be indicated by the intestinal-type mucin, MUC2. Warson, C., Van De Bovenkamp, J.H., Korteland-Van Male, A.M., Büller, H.A., Einerhand, A.W., Ectors, N.L., Dekker, J. Hum. Pathol. (2002) [Pubmed]
  36. Developmental patterns of mucin gene expression in human fetal small intestinal xenografts maintained in severe-combined immunodeficient mice. Buisine, M.P., Aubert, J.P., Walker, W.A., Savidge, T.C. Pediatr. Res. (2003) [Pubmed]
  37. MUC4 is increased in high grade intraepithelial neoplasia in Barrett's oesophagus and is associated with a proapoptotic Bax to Bcl-2 ratio. Bax, D.A., Haringsma, J., Einerhand, A.W., van Dekken, H., Blok, P., Siersema, P.D., Kuipers, E.J., Kusters, J.G. J. Clin. Pathol. (2004) [Pubmed]
  38. Proinflammatory cytokines trigger MUC gene expression and mucin release in the intestinal cancer cell line LS180. Enss, M.L., Cornberg, M., Wagner, S., Gebert, A., Henrichs, M., Eisenblätter, R., Beil, W., Kownatzki, R., Hedrich, H.J. Inflamm. Res. (2000) [Pubmed]
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