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Chemical Compound Review

DZAri     (1R,2S,3R,5R)-3-(5-amino- 4,7,9...

Synonyms: CHEMBL268272, SRI-6251, AG-J-28240, ND-0224, KST-1A6396, ...
 
 
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Disease relevance of DZAri

  • In contrast to 3-deazaaristeromycin, 3DA-Ado inhibits the synthesis of late influenza A virus proteins in chicken embryo cells (CEC), while it causes an overproduction of early proteins and of the nonstructural proteins NS2 and M2 [1].
 

High impact information on DZAri

 

Biological context of DZAri

 

Associations of DZAri with other chemical compounds

References

  1. Specific inhibition of the synthesis of influenza virus late proteins and stimulation of early, M2, and NS2 protein synthesis by 3-deazaadenosine. Fischer, A.A., Müller, K., Scholtissek, C. Virology (1990) [Pubmed]
  2. Basis for resistance to 3-deazaaristeromycin, an inhibitor of S-adenosylhomocysteine hydrolase, in human B-lymphoblasts. Greenberg, M.L., Chaffee, S., Hershfield, M.S. J. Biol. Chem. (1989) [Pubmed]
  3. Mechanism of the cytostatic activity of 3-deazaaristeromycin, an inhibitor of adenosylhomocysteine hydrolase. Kim, I.K., Aksamit, R.R., Cantoni, G.L. J. Biol. Chem. (1982) [Pubmed]
  4. Inhibition of chemotaxis by S-3-deazaadenosylhomocysteine in a mouse macrophage cell line. Aksamit, R.R., Falk, W., Cantoni, G.L. J. Biol. Chem. (1982) [Pubmed]
  5. Cysteamine increases homocysteine export and glutathione content by independent mechanisms in C3H/10T1/2 cells. Djurhuus, R., Svardal, A.M., Ueland, P.M. Mol. Pharmacol. (1990) [Pubmed]
  6. Erythroid differentiation and regulatory gene expression are modulated by adenosine derivatives interfering with S-adenosylmethionine metabolic pathway. Scarpa, S., Narzi, L., Lucarelli, M., Orrù, L., Strom, R. J. Cell. Biochem. (2001) [Pubmed]
  7. Effects of the S-adenosylhomocysteine hydrolase inhibitors 3-deazaadenosine and 3-deazaaristeromycin on RNA methylation and synthesis. Backlund, P.S., Carotti, D., Cantoni, G.L. Eur. J. Biochem. (1986) [Pubmed]
  8. 3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60. Glazer, R.I., Hartman, K.D., Knode, M.C., Richard, M.M., Chiang, P.K., Tseng, C.K., Marquez, V.E. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
 
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